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Protein
Submitted name:

3'-phosphoadenosine 5'-phosphosulfate synthase 1

Gene

PAPSS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3'-phosphoadenosine 5'-phosphosulfate synthase 1Imported
Submitted name:
PAPSS1 proteinImported
Submitted name:
cDNA FLJ76465, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), mRNAImported
Gene namesi
Name:PAPSS1Imported
ORF Names:hCG_20920Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA384.

Expressioni

Gene expression databases

BgeeiENSG00000138801.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265174.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 385PUA_2InterPro annotationAdd BLAST153
Domaini394 – 616ATP-sulfurylaseInterPro annotationAdd BLAST223

Phylogenomic databases

eggNOGiKOG0635. Eukaryota.
KOG4238. Eukaryota.
COG0529. LUCA.
COG2046. LUCA.
HOVERGENiHBG053503.
KOiK13811.
OMAiRRPEFYY.
OrthoDBiEOG091G07ZR.

Family and domain databases

CDDicd02027. APSK. 1 hit.
cd00517. ATPS. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR025980. ATP-Sase_PUA-like_dom.
IPR027417. P-loop_NTPase.
IPR015947. PUA-like_domain.
IPR014729. Rossmann-like_a/b/a_fold.
IPR024951. Sulfurylase_cat_dom.
IPR002650. Sulphate_adenylyltransferase.
[Graphical view]
PfamiPF01747. ATP-sulfurylase. 1 hit.
PF14306. PUA_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
TIGR00339. sopT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IAX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPGSLCKK VKLSNNAQNW GMQRATNVTY QAHHVSRNKR GQVVGTRGGF
60 70 80 90 100
RGCTVWLTGL SGAGKTTVSM ALEEYLVCHG IPCYTLDGDN IRQGLNKNLG
110 120 130 140 150
FSPEDREENV RRIAEVAKLF ADAGLVCITS FISPYTQDRN NARQIHEGAS
160 170 180 190 200
LPFFEVFVDA PLHVCEQRDV KGLYKKARAG EIKGFTGIDS EYEKPEAPEL
210 220 230 240 250
VLKTDSCDVN DCVQQVVELL QERDIVPVDA SYEVKELYVP ENKLHLAKTD
260 270 280 290 300
AETLPALKIN KVDMQWVQVL AEGWATPLNG FMREREYLQC LHFDCLLDGG
310 320 330 340 350
VINLSVPIVL TATHEDKERL DGCTAFALMY EGRRVAILRN PEFFEHRKEE
360 370 380 390 400
RCARQWGTTC KNHPYIKMVM EQGDWLIGGD LQVLDRVYWN DGLDQYRLTP
410 420 430 440 450
TELKQKFKDM NADAVFAFQL RNPVHNGHAL LMQDTHKQLL ERGYRRPVLL
460 470 480 490 500
LHPLGGWTKD DDVPLMWRMK QHAAVLEEGV LNPETTVVAI FPSPMMYAGP
510 520 530 540 550
TEVQWHCRAR MVAGANFYIV GRDPAGMPHP ETGKDLYEPS HGAKVLTMAP
560 570 580 590 600
GLITLEIVPF RVAAYNKKKK RMDYYDSEHH EDFEFISGTR MRKLAREGQK
610 620
PPEGFMAPKA WTVLTEYYKS LEKA
Length:624
Mass (Da):70,833
Last modified:May 10, 2005 - v1
Checksum:iA3DC9B943E68CDD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292774 mRNA. Translation: BAF85463.1.
CR457028 mRNA. Translation: CAG33309.1.
CH471057 Genomic DNA. Translation: EAX06210.1.
RefSeqiNP_005434.4. NM_005443.4.
UniGeneiHs.368610.

Genome annotation databases

GeneIDi9061.
KEGGihsa:9061.
UCSCiuc003hyk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292774 mRNA. Translation: BAF85463.1.
CR457028 mRNA. Translation: CAG33309.1.
CH471057 Genomic DNA. Translation: EAX06210.1.
RefSeqiNP_005434.4. NM_005443.4.
UniGeneiHs.368610.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265174.

Protocols and materials databases

DNASUi9061.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9061.
KEGGihsa:9061.
UCSCiuc003hyk.4. human.

Organism-specific databases

CTDi9061.
PharmGKBiPA384.

Phylogenomic databases

eggNOGiKOG0635. Eukaryota.
KOG4238. Eukaryota.
COG0529. LUCA.
COG2046. LUCA.
HOVERGENiHBG053503.
KOiK13811.
OMAiRRPEFYY.
OrthoDBiEOG091G07ZR.

Miscellaneous databases

ChiTaRSiPAPSS1. human.
GenomeRNAii9061.

Gene expression databases

BgeeiENSG00000138801.

Family and domain databases

CDDicd02027. APSK. 1 hit.
cd00517. ATPS. 1 hit.
Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR025980. ATP-Sase_PUA-like_dom.
IPR027417. P-loop_NTPase.
IPR015947. PUA-like_domain.
IPR014729. Rossmann-like_a/b/a_fold.
IPR024951. Sulfurylase_cat_dom.
IPR002650. Sulphate_adenylyltransferase.
[Graphical view]
PfamiPF01747. ATP-sulfurylase. 1 hit.
PF14306. PUA_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
TIGR00339. sopT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IAX6_HUMAN
AccessioniPrimary (citable) accession number: Q6IAX6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.