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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
Synonyms:HEL-S-46eImported
ORF Names:hCG_24071Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16.

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28642.

PTM / Processingi

Proteomic databases

MaxQBiQ6IAT1.

Expressioni

Gene expression databases

BgeeiENSG00000057608.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6IAT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
HOVERGENiHBG000839.
KOiK17255.
OMAiYKRMMGS.
OrthoDBiEOG091G06PV.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6IAT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKIPG SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVTEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI
410 420 430 440
SRTYDATTHF ETTCDDIKNI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,663
Last modified:May 10, 2005 - v1
Checksum:iCE186A2E3A47FCC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei445Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794614 mRNA. Translation: ACJ13668.1.
AK312485 mRNA. Translation: BAG35388.1.
AB451295 mRNA. Translation: BAG70109.1.
AB451429 mRNA. Translation: BAG70243.1.
CR457073 mRNA. Translation: CAG33354.1.
CH471072 Genomic DNA. Translation: EAW86431.1.
CH471072 Genomic DNA. Translation: EAW86432.1.
RefSeqiNP_001108628.1. NM_001115156.1.
NP_001485.2. NM_001494.3.
UniGeneiHs.299055.

Genome annotation databases

GeneIDi2665.
KEGGihsa:2665.
UCSCiuc001iil.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6IAT1_HUMAN
AccessioniPrimary (citable) accession number: Q6IAT1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.