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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
Synonyms:HEL-S-46eImported
ORF Names:hCG_24071Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28642

PTM / Processingi

Proteomic databases

MaxQBiQ6IAT1
PRIDEiQ6IAT1

Expressioni

Gene expression databases

BgeeiENSG00000057608
ExpressionAtlasiQ6IAT1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6IAT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
HOVERGENiHBG000839
KOiK17255
OMAiRMMGSEF
OrthoDBiEOG091G06PV

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Q6IAT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKIPG SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVTEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI
410 420 430 440
SRTYDATTHF ETTCDDIKNI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,663
Last modified:May 10, 2005 - v1
Checksum:iCE186A2E3A47FCC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei445Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794614 mRNA Translation: ACJ13668.1
AK312485 mRNA Translation: BAG35388.1
AB451295 mRNA Translation: BAG70109.1
AB451429 mRNA Translation: BAG70243.1
CR457073 mRNA Translation: CAG33354.1
CH471072 Genomic DNA Translation: EAW86431.1
CH471072 Genomic DNA Translation: EAW86432.1
RefSeqiNP_001108628.1, NM_001115156.1
NP_001485.2, NM_001494.3
UniGeneiHs.299055

Genome annotation databases

GeneIDi2665
KEGGihsa:2665
UCSCiuc001iil.4 human

Similar proteinsi

Entry informationi

Entry nameiQ6IAT1_HUMAN
AccessioniPrimary (citable) accession number: Q6IAT1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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