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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

DHRS7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941SubstrateSequence Analysis
Active sitei207 – 2071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 11 Publication
Gene namesi
Name:DHRS7B
Synonyms:SDR32C11 Publication
ORF Names:CGI-93, UNQ212/PRO238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24547. DHRS7B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini39 – 325287LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671976.

Polymorphism and mutation databases

BioMutaiDHRS7B.
DMDMi162416270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Dehydrogenase/reductase SDR family member 7BPRO_0000312105Add
BLAST

Proteomic databases

MaxQBiQ6IAN0.
PaxDbiQ6IAN0.
PRIDEiQ6IAN0.

PTM databases

PhosphoSiteiQ6IAN0.

Expressioni

Gene expression databases

BgeeiQ6IAN0.
CleanExiHS_DHRS7B.
ExpressionAtlasiQ6IAN0. baseline and differential.
GenevestigatoriQ6IAN0.

Organism-specific databases

HPAiHPA012132.
HPA016873.

Interactioni

Protein-protein interaction databases

BioGridi117463. 8 interactions.
IntActiQ6IAN0. 4 interactions.
MINTiMINT-4901734.
STRINGi9606.ENSP00000378887.

Structurei

3D structure databases

ProteinModelPortaliQ6IAN0.
SMRiQ6IAN0. Positions 50-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00770000120481.
HOVERGENiHBG107825.
InParanoidiQ6IAN0.
KOiK11166.
OMAiFPITIPW.
PhylomeDBiQ6IAN0.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IAN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL
60 70 80 90 100
RNAVVVITGA TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH
110 120 130 140 150
ATKVQTHKPY LVTFDLTDSG AIVAAAAEIL QCFGYVDILV NNAGISYRGT
160 170 180 190 200
IMDTTVDVDK RVMETNYFGP VALTKALLPS MIKRRQGHIV AISSIQGKMS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI HTNLSVNAIT
260 270 280 290 300
ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
310 320
RTLAPGLFFS LMASRARKER KSKNS
Length:325
Mass (Da):35,119
Last modified:December 4, 2007 - v2
Checksum:i18F4A4C40D3B95CE
GO

Sequence cautioni

The sequence AAD34088.1 differs from that shown. Reason: Frameshift at positions 12 and 266. Curated
The sequence AAQ88862.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101S → P in CAB55997 (PubMed:11230166).Curated
Sequence conflicti256 – 2561Y → C in CAB55997 (PubMed:11230166).Curated
Sequence conflicti312 – 3121M → T in CAG33405 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151851 mRNA. Translation: AAD34088.1. Frameshift.
AL117567 mRNA. Translation: CAB55997.1.
CR457124 mRNA. Translation: CAG33405.1.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02596.1.
BC004126 mRNA. Translation: AAH04126.1.
BC009679 mRNA. Translation: AAH09679.1.
AY358498 mRNA. Translation: AAQ88862.1. Different initiation.
CCDSiCCDS11215.1.
PIRiT17307.
RefSeqiNP_056325.2. NM_015510.4.
XP_005256653.1. XM_005256596.2.
UniGeneiHs.386989.

Genome annotation databases

EnsembliENST00000395511; ENSP00000378887; ENSG00000109016.
GeneIDi25979.
KEGGihsa:25979.
UCSCiuc002gyo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151851 mRNA. Translation: AAD34088.1. Frameshift.
AL117567 mRNA. Translation: CAB55997.1.
CR457124 mRNA. Translation: CAG33405.1.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02596.1.
BC004126 mRNA. Translation: AAH04126.1.
BC009679 mRNA. Translation: AAH09679.1.
AY358498 mRNA. Translation: AAQ88862.1. Different initiation.
CCDSiCCDS11215.1.
PIRiT17307.
RefSeqiNP_056325.2. NM_015510.4.
XP_005256653.1. XM_005256596.2.
UniGeneiHs.386989.

3D structure databases

ProteinModelPortaliQ6IAN0.
SMRiQ6IAN0. Positions 50-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117463. 8 interactions.
IntActiQ6IAN0. 4 interactions.
MINTiMINT-4901734.
STRINGi9606.ENSP00000378887.

PTM databases

PhosphoSiteiQ6IAN0.

Polymorphism and mutation databases

BioMutaiDHRS7B.
DMDMi162416270.

Proteomic databases

MaxQBiQ6IAN0.
PaxDbiQ6IAN0.
PRIDEiQ6IAN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395511; ENSP00000378887; ENSG00000109016.
GeneIDi25979.
KEGGihsa:25979.
UCSCiuc002gyo.3. human.

Organism-specific databases

CTDi25979.
GeneCardsiGC17P022221.
H-InvDBHIX0013628.
HGNCiHGNC:24547. DHRS7B.
HPAiHPA012132.
HPA016873.
MIMi616160. gene.
neXtProtiNX_Q6IAN0.
PharmGKBiPA142671976.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00770000120481.
HOVERGENiHBG107825.
InParanoidiQ6IAN0.
KOiK11166.
OMAiFPITIPW.
PhylomeDBiQ6IAN0.
TreeFamiTF313474.

Miscellaneous databases

ChiTaRSiDHRS7B. human.
GeneWikiiDHRS7B.
GenomeRNAii25979.
NextBioi47634.
PROiQ6IAN0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IAN0.
CleanExiHS_DHRS7B.
ExpressionAtlasiQ6IAN0. baseline and differential.
GenevestigatoriQ6IAN0.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-325.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiDRS7B_HUMAN
AccessioniPrimary (citable) accession number: Q6IAN0
Secondary accession number(s): B5MEF4
, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 27, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.