Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6IAN0

- DRS7B_HUMAN

UniProt

Q6IAN0 - DRS7B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dehydrogenase/reductase SDR family member 7B

Gene

DHRS7B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941SubstrateSequence Analysis
Active sitei207 – 2071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8025NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Gene namesi
Name:DHRS7B
ORF Names:CGI-93, UNQ212/PRO238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24547. DHRS7B.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Dehydrogenase/reductase SDR family member 7BPRO_0000312105Add
BLAST

Proteomic databases

MaxQBiQ6IAN0.
PaxDbiQ6IAN0.
PRIDEiQ6IAN0.

PTM databases

PhosphoSiteiQ6IAN0.

Expressioni

Gene expression databases

BgeeiQ6IAN0.
CleanExiHS_DHRS7B.
ExpressionAtlasiQ6IAN0. baseline and differential.
GenevestigatoriQ6IAN0.

Organism-specific databases

HPAiHPA012132.
HPA016873.

Interactioni

Protein-protein interaction databases

BioGridi117463. 8 interactions.
IntActiQ6IAN0. 4 interactions.
MINTiMINT-4901734.
STRINGi9606.ENSP00000378887.

Structurei

3D structure databases

ProteinModelPortaliQ6IAN0.
SMRiQ6IAN0. Positions 46-311.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini39 – 325287LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118798.
HOVERGENiHBG107825.
InParanoidiQ6IAN0.
KOiK11166.
OMAiVQTHKPH.
PhylomeDBiQ6IAN0.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IAN0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL
60 70 80 90 100
RNAVVVITGA TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH
110 120 130 140 150
ATKVQTHKPY LVTFDLTDSG AIVAAAAEIL QCFGYVDILV NNAGISYRGT
160 170 180 190 200
IMDTTVDVDK RVMETNYFGP VALTKALLPS MIKRRQGHIV AISSIQGKMS
210 220 230 240 250
IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI HTNLSVNAIT
260 270 280 290 300
ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL
310 320
RTLAPGLFFS LMASRARKER KSKNS
Length:325
Mass (Da):35,119
Last modified:December 4, 2007 - v2
Checksum:i18F4A4C40D3B95CE
GO

Sequence cautioni

The sequence AAD34088.1 differs from that shown. Reason: Frameshift at positions 12 and 266.
The sequence AAQ88862.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101S → P in CAB55997. (PubMed:11230166)Curated
Sequence conflicti256 – 2561Y → C in CAB55997. (PubMed:11230166)Curated
Sequence conflicti312 – 3121M → T in CAG33405. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151851 mRNA. Translation: AAD34088.1. Frameshift.
AL117567 mRNA. Translation: CAB55997.1.
CR457124 mRNA. Translation: CAG33405.1.
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02596.1.
BC004126 mRNA. Translation: AAH04126.1.
BC009679 mRNA. Translation: AAH09679.1.
AY358498 mRNA. Translation: AAQ88862.1. Different initiation.
CCDSiCCDS11215.1.
PIRiT17307.
RefSeqiNP_056325.2. NM_015510.4.
XP_005256653.1. XM_005256596.1.
UniGeneiHs.386989.

Genome annotation databases

EnsembliENST00000395511; ENSP00000378887; ENSG00000109016.
ENST00000579303; ENSP00000468585; ENSG00000109016.
GeneIDi25979.
KEGGihsa:25979.
UCSCiuc002gyo.3. human.

Polymorphism databases

DMDMi162416270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151851 mRNA. Translation: AAD34088.1 . Frameshift.
AL117567 mRNA. Translation: CAB55997.1 .
CR457124 mRNA. Translation: CAG33405.1 .
AC087393 Genomic DNA. No translation available.
CH471210 Genomic DNA. Translation: EAX02596.1 .
BC004126 mRNA. Translation: AAH04126.1 .
BC009679 mRNA. Translation: AAH09679.1 .
AY358498 mRNA. Translation: AAQ88862.1 . Different initiation.
CCDSi CCDS11215.1.
PIRi T17307.
RefSeqi NP_056325.2. NM_015510.4.
XP_005256653.1. XM_005256596.1.
UniGenei Hs.386989.

3D structure databases

ProteinModelPortali Q6IAN0.
SMRi Q6IAN0. Positions 46-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117463. 8 interactions.
IntActi Q6IAN0. 4 interactions.
MINTi MINT-4901734.
STRINGi 9606.ENSP00000378887.

PTM databases

PhosphoSitei Q6IAN0.

Polymorphism databases

DMDMi 162416270.

Proteomic databases

MaxQBi Q6IAN0.
PaxDbi Q6IAN0.
PRIDEi Q6IAN0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395511 ; ENSP00000378887 ; ENSG00000109016 .
ENST00000579303 ; ENSP00000468585 ; ENSG00000109016 .
GeneIDi 25979.
KEGGi hsa:25979.
UCSCi uc002gyo.3. human.

Organism-specific databases

CTDi 25979.
GeneCardsi GC17P022221.
H-InvDB HIX0013628.
HGNCi HGNC:24547. DHRS7B.
HPAi HPA012132.
HPA016873.
neXtProti NX_Q6IAN0.
PharmGKBi PA142671976.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00760000118798.
HOVERGENi HBG107825.
InParanoidi Q6IAN0.
KOi K11166.
OMAi VQTHKPH.
PhylomeDBi Q6IAN0.
TreeFami TF313474.

Miscellaneous databases

ChiTaRSi DHRS7B. human.
GeneWikii DHRS7B.
GenomeRNAii 25979.
NextBioi 47634.
PROi Q6IAN0.

Gene expression databases

Bgeei Q6IAN0.
CleanExi HS_DHRS7B.
ExpressionAtlasi Q6IAN0. baseline and differential.
Genevestigatori Q6IAN0.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-325.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDRS7B_HUMAN
AccessioniPrimary (citable) accession number: Q6IAN0
Secondary accession number(s): B5MEF4
, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3