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Q6IAN0

- DRS7B_HUMAN

UniProt

Q6IAN0 - DRS7B_HUMAN

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Protein
Dehydrogenase/reductase SDR family member 7B
Gene
DHRS7B, CGI-93, UNQ212/PRO238
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Putative oxidoreductase Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941Substrate Reviewed prediction
Active sitei207 – 2071Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 8025NAD or NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
    Gene namesi
    Name:DHRS7B
    ORF Names:CGI-93, UNQ212/PRO238
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24547. DHRS7B.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei18 – 3821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
    Add
    BLAST
    Topological domaini39 – 325287Lumenal Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. peroxisomal membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671976.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Dehydrogenase/reductase SDR family member 7B
    PRO_0000312105Add
    BLAST

    Proteomic databases

    MaxQBiQ6IAN0.
    PaxDbiQ6IAN0.
    PRIDEiQ6IAN0.

    PTM databases

    PhosphoSiteiQ6IAN0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6IAN0.
    BgeeiQ6IAN0.
    CleanExiHS_DHRS7B.
    GenevestigatoriQ6IAN0.

    Organism-specific databases

    HPAiHPA012132.
    HPA016873.

    Interactioni

    Protein-protein interaction databases

    BioGridi117463. 8 interactions.
    IntActiQ6IAN0. 4 interactions.
    MINTiMINT-4901734.
    STRINGi9606.ENSP00000378887.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IAN0.
    SMRiQ6IAN0. Positions 50-265.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG107825.
    InParanoidiQ6IAN0.
    KOiK11166.
    OMAiVQTHKPH.
    PhylomeDBiQ6IAN0.
    TreeFamiTF313474.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IAN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL    50
    RNAVVVITGA TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH 100
    ATKVQTHKPY LVTFDLTDSG AIVAAAAEIL QCFGYVDILV NNAGISYRGT 150
    IMDTTVDVDK RVMETNYFGP VALTKALLPS MIKRRQGHIV AISSIQGKMS 200
    IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI HTNLSVNAIT 250
    ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL 300
    RTLAPGLFFS LMASRARKER KSKNS 325
    Length:325
    Mass (Da):35,119
    Last modified:December 4, 2007 - v2
    Checksum:i18F4A4C40D3B95CE
    GO

    Sequence cautioni

    The sequence AAD34088.1 differs from that shown. Reason: Frameshift at positions 12 and 266.
    The sequence AAQ88862.1 differs from that shown. Reason: Erroneous initiation.

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti210 – 2101S → P in CAB55997. 1 Publication
    Sequence conflicti256 – 2561Y → C in CAB55997. 1 Publication
    Sequence conflicti312 – 3121M → T in CAG33405. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151851 mRNA. Translation: AAD34088.1. Frameshift.
    AL117567 mRNA. Translation: CAB55997.1.
    CR457124 mRNA. Translation: CAG33405.1.
    AC087393 Genomic DNA. No translation available.
    CH471210 Genomic DNA. Translation: EAX02596.1.
    BC004126 mRNA. Translation: AAH04126.1.
    BC009679 mRNA. Translation: AAH09679.1.
    AY358498 mRNA. Translation: AAQ88862.1. Different initiation.
    CCDSiCCDS11215.1.
    PIRiT17307.
    RefSeqiNP_056325.2. NM_015510.4.
    XP_005256653.1. XM_005256596.1.
    UniGeneiHs.386989.

    Genome annotation databases

    EnsembliENST00000395511; ENSP00000378887; ENSG00000109016.
    ENST00000579303; ENSP00000468585; ENSG00000109016.
    GeneIDi25979.
    KEGGihsa:25979.
    UCSCiuc002gyo.3. human.

    Polymorphism databases

    DMDMi162416270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151851 mRNA. Translation: AAD34088.1 . Frameshift.
    AL117567 mRNA. Translation: CAB55997.1 .
    CR457124 mRNA. Translation: CAG33405.1 .
    AC087393 Genomic DNA. No translation available.
    CH471210 Genomic DNA. Translation: EAX02596.1 .
    BC004126 mRNA. Translation: AAH04126.1 .
    BC009679 mRNA. Translation: AAH09679.1 .
    AY358498 mRNA. Translation: AAQ88862.1 . Different initiation.
    CCDSi CCDS11215.1.
    PIRi T17307.
    RefSeqi NP_056325.2. NM_015510.4.
    XP_005256653.1. XM_005256596.1.
    UniGenei Hs.386989.

    3D structure databases

    ProteinModelPortali Q6IAN0.
    SMRi Q6IAN0. Positions 50-265.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 117463. 8 interactions.
    IntActi Q6IAN0. 4 interactions.
    MINTi MINT-4901734.
    STRINGi 9606.ENSP00000378887.

    PTM databases

    PhosphoSitei Q6IAN0.

    Polymorphism databases

    DMDMi 162416270.

    Proteomic databases

    MaxQBi Q6IAN0.
    PaxDbi Q6IAN0.
    PRIDEi Q6IAN0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395511 ; ENSP00000378887 ; ENSG00000109016 .
    ENST00000579303 ; ENSP00000468585 ; ENSG00000109016 .
    GeneIDi 25979.
    KEGGi hsa:25979.
    UCSCi uc002gyo.3. human.

    Organism-specific databases

    CTDi 25979.
    GeneCardsi GC17P021531.
    H-InvDB HIX0013628.
    HGNCi HGNC:24547. DHRS7B.
    HPAi HPA012132.
    HPA016873.
    neXtProti NX_Q6IAN0.
    PharmGKBi PA142671976.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG107825.
    InParanoidi Q6IAN0.
    KOi K11166.
    OMAi VQTHKPH.
    PhylomeDBi Q6IAN0.
    TreeFami TF313474.

    Miscellaneous databases

    ChiTaRSi DHRS7B. human.
    GeneWikii DHRS7B.
    GenomeRNAii 25979.
    NextBioi 47634.
    PROi Q6IAN0.

    Gene expression databases

    ArrayExpressi Q6IAN0.
    Bgeei Q6IAN0.
    CleanExi HS_DHRS7B.
    Genevestigatori Q6IAN0.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-325.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDRS7B_HUMAN
    AccessioniPrimary (citable) accession number: Q6IAN0
    Secondary accession number(s): B5MEF4
    , Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: July 9, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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