Q6IAN0 (DRS7B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dehydrogenase/reductase SDR family member 7B
EC=1.1.-.-

Gene names

Name:	DHRS7B
ORF Names:	CGI-93, UNQ212/PRO238

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative oxidoreductase Potential.
Subcellular location	Peroxisome membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence caution	The sequence AAD34088.1 differs from that shown. Reason: Frameshift at positions 12 and 266. The sequence AAQ88862.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane Peroxisome
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peroxisomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Dehydrogenase/reductase SDR family member 7B		PRO_0000312105
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	39 – 325	287	Peroxisomal Potential
	Nucleotide binding	56 – 80	25	NAD or NADP By similarity
Sites
	Active site	207	1	Proton acceptor By similarity
	Binding site	194	1	Substrate Potential
Experimental info
	Sequence conflict	210	1	S → P in CAB55997. Ref.2
	Sequence conflict	256	1	Y → C in CAB55997. Ref.2
	Sequence conflict	312	1	M → T in CAG33405. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6IAN0 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: 18F4A4C40D3B95CE	FASTA	325	35,119
	10 20 30 40 50 60 MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA 70 80 90 100 110 120 TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG 130 140 150 160 170 180 AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS 190 200 210 220 230 240 MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI 250 260 270 280 290 300 HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL 310 320 RTLAPGLFFS LMASRARKER KSKNS

References

[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-325.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151851 mRNA. Translation: AAD34088.1. Frameshift. AL117567 mRNA. Translation: CAB55997.1. CR457124 mRNA. Translation: CAG33405.1. AC087393 Genomic DNA. No translation available. CH471210 Genomic DNA. Translation: EAX02596.1. BC004126 mRNA. Translation: AAH04126.1. BC009679 mRNA. Translation: AAH09679.1. AY358498 mRNA. Translation: AAQ88862.1. Different initiation.
IPI	IPI00550165.
PIR	T17307.
RefSeq	NP_056325.2. NM_015510.4.
UniGene	Hs.386989.
3D structure databases
HSSP	HSSP built from PDB template 1YB1 based on UniProtKB Q8NBQ5.
ProteinModelPortal	Q6IAN0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6IAN0. 4 interactions.
MINT	MINT-4901734.
STRING	9606.ENSP00000378887.
PTM databases
PhosphoSite	Q6IAN0.
Polymorphism databases
DMDM	162416270.
Proteomic databases
PaxDb	Q6IAN0.
PRIDE	Q6IAN0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395511; ENSP00000378887; ENSG00000109016. ENST00000579303; ENSP00000468585; ENSG00000109016.
GeneID	25979.
KEGG	hsa:25979.
UCSC	uc002gyo.3. human.
Organism-specific databases
CTD	25979.
GeneCards	GC17P021030.
H-InvDB	HIX0013628.
HGNC	HGNC:24547. DHRS7B.
HPA	HPA012132. HPA016873.
neXtProt	NX_Q6IAN0.
PharmGKB	PA142671976.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1028.
HOVERGEN	HBG107825.
InParanoid	Q6IAN0.
KO	K11166.
OMA	LGRECAK.
OrthoDB	EOG4D52ZD.
PhylomeDB	Q6IAN0.
Gene expression databases
Bgee	Q6IAN0.
CleanEx	HS_DHRS7B.
Genevestigator	Q6IAN0.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DHRS7B. human.
GenomeRNAi	25979.
NextBio	47634.

Entry information

Entry name

DRS7B_HUMAN

Accession

Primary (citable) accession number: Q6IAN0
Secondary accession number(s): B5MEF4 , Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.