ID   Q6I9Y8_HUMAN            Unreviewed;       757 AA.
AC   Q6I9Y8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=IPO4 protein {ECO:0000313|EMBL:CAG33648.1};
GN   Name=IPO4 {ECO:0000313|EMBL:CAG33648.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAG33648.1};
RN   [1] {ECO:0000313|EMBL:CAG33648.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; CR457367; CAG33648.1; -; mRNA.
DR   AlphaFoldDB; Q6I9Y8; -.
DR   SMR; Q6I9Y8; -.
DR   PeptideAtlas; Q6I9Y8; -.
DR   ChiTaRS; IPO4; human.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF13513; HEAT_EZ; 2.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          15..259
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          67..107
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          576..614
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   757 AA;  82402 MW;  2B32741DB2E1D7A9 CRC64;
     MGETPKHFAV QVVDMLALHL PPEKLCPQLM PMLEEALRSE SPYQRKAGLL VLAVLSDGAG
     DHIRQRLLPP LLQIVCKGLE DPSQVVRNAA LFALGQFSEN LQPHISSYSR EVMPLLLAYL
     KSVPLGHTHH LAKACYALEN FVENLGPKVQ PYLPELMECM LQLLRNPSSP RAKELAVSAL
     GAIATAAQAS LLPYFPAIME HLREFLLTGR EDLQPVQIQS LETLGVLARA VGEPMRPLAE
     ECCQLGLGLC DQVDDPDLRR CTYSLFAALS GLMGEGLAPH LEQITTLMLL SLRSTEGIVP
     QYDGSSSFLL FDDESDGEEE EELMDEDVEE EDDSEISGYS VENAFFDEKE DTCAAVGEIS
     VNTSVAFLPY MESVFEEVFK LLECPHLNVR KAAHEALGQF CCALHKACQS CPSEPNTAAL
     QAALARVVPS YMQAVNRERE RQVVMAVLEA LTGVLRSCGT LTLKPPGRLA ELCGVLKAVL
     QRKTACQDTD EEEEEEDDDQ AEYDAMLLEH AGEAIPALAA AAGGDSFAPF FAGFLPLLVC
     KTKQGCTVAE KSFAVGTLAE TIQGLGAASA QFVSRLLPVL LSTAQEADPE VRSNAIFGMG
     VLAEHGGHPA QEHFPKLLGL LFPLLARERH DRVRDNICGA LARLLMASPT RKPEPQVLAA
     LLHALPLKED LEEWVTIGRL FSFLYQSSPD QVIDVAPELL RICSLILADN KIPPDTKAAL
     LLLLTFLAKQ HTDSFQAALG SLPVDKAQEL QAVLGLS
//