Unreviewed, UniProtKB/TrEMBL Q6I9T8 (Q6I9T8_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase RuleBase RU004273V0
    EC=3.1.3.16 RuleBase RU004273V0

Gene names

Name:

PPP2CA EMBL CAG33698.1

Organism

Homo sapiens (Human) EMBL CAG33698.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. RuleBase RU004273V0
Sequence similarities	Belongs to the PPP phosphatase family.

Ontologies

Keywords
Ligand	Iron RuleBase RU004273V0
Molecular function	Hydrolase Spearmint SPM006186 RuleBase RU004273V0
Gene Ontology (GO)
Biological process	mesoderm development Inferred from electronic annotation. Source: Compara protein amino acid dephosphorylation Inferred from electronic annotation. Source: Compara
Cellular component	cytosol Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara protein phosphatase type 2A complex Inferred from electronic annotation. Source: Compara
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: EC protein C-terminus binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6I9T8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E308590406C64B72	FASTA	309	35,550
	10 20 30 40 50 60 MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 70 80 90 100 110 120 QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 130 140 150 160 170 180 KQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 190 200 210 220 230 240 RALDRPQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 250 260 270 280 290 300 HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV TRRTPDYFL

References

[1]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR457417 mRNA. Translation: CAG33698.1.
IPI	IPI00815784.
UniGene	Hs.105818
3D structure databases
HSSP	HSSP built from PDB template 1AUI based on UniProtKB Q08209.
SMR	Q6I9T8. Positions 2-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6I9T8.
Proteomic databases
PRIDE	Q6I9T8.
Genome annotation databases
Ensembl	ENST00000481195; ENSP00000418447; ENSG00000113575; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:9299. PPP2CA.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6I9T8.
PhylomeDB	Q6I9T8.
Gene expression databases
ArrayExpress	Q6I9T8.
Bgee	Q6I9T8.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
PANTHER	PTHR11668. T_phtase_apaH. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6I9T8_HUMAN

Accession

Primary (citable) accession number: Q6I9T8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.