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Protein

C-C motif chemokine

Gene

CCL11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokineUniRule annotation
Gene namesi
Name:CCL11Imported
ORF Names:hCG_29299Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500999892924 – 97C-C motif chemokineUniRule annotationAdd BLAST74

Expressioni

Gene expression databases

BgeeiENSG00000172156.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302234.

Structurei

3D structure databases

SMRiQ6I9T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 88SCYInterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
HOVERGENiHBG017871.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG091G14KV.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6I9T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR
60 70 80 90
RITSGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
Length:97
Mass (Da):10,732
Last modified:May 10, 2005 - v1
Checksum:iB433C30FDA4C71A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064768 Genomic DNA. Translation: ABK41951.1.
CR457421 mRNA. Translation: CAG33702.1.
CH471147 Genomic DNA. Translation: EAW80209.1.
RefSeqiNP_002977.1. NM_002986.2.
UniGeneiHs.54460.

Genome annotation databases

GeneIDi6356.
KEGGihsa:6356.
UCSCiuc002hia.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064768 Genomic DNA. Translation: ABK41951.1.
CR457421 mRNA. Translation: CAG33702.1.
CH471147 Genomic DNA. Translation: EAW80209.1.
RefSeqiNP_002977.1. NM_002986.2.
UniGeneiHs.54460.

3D structure databases

SMRiQ6I9T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302234.

Protocols and materials databases

DNASUi6356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6356.
KEGGihsa:6356.
UCSCiuc002hia.2. human.

Organism-specific databases

CTDi6356.
PharmGKBiPA35543.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
HOVERGENiHBG017871.
KOiK16597.
OMAiGSKCPQK.
OrthoDBiEOG091G14KV.

Miscellaneous databases

GenomeRNAii6356.

Gene expression databases

BgeeiENSG00000172156.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6I9T4_HUMAN
AccessioniPrimary (citable) accession number: Q6I9T4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 7, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.