Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chainUniRule annotation
Gene namesi
Name:CGAImported
Synonyms:FSHAImported, GPA1Imported
ORF Names:hCG_33165Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000135346.8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501420594125 – 116Glycoprotein hormones alpha chainUniRule annotationAdd BLAST92

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Proteomic databases

MaxQBiQ6I9S8

Expressioni

Gene expression databases

BgeeiENSG00000135346
ExpressionAtlasiQ6I9S8 baseline and differential

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6I9S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit alpha family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
HOVERGENiHBG000452
KOiK08522

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6I9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60 70 80 90 100
QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV
110
ENHTACHCST CYYHKS
Length:116
Mass (Da):13,075
Last modified:May 10, 2005 - v1
Checksum:iF0623CD8CC90CFCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU081886 Genomic DNA Translation: ABU96751.1
FJ624079 mRNA Translation: ACM91588.1
AK311972 mRNA Translation: BAG34911.1
CR457427 mRNA Translation: CAG33708.1
HF564671 Genomic DNA Translation: CCP37876.1
CH471051 Genomic DNA Translation: EAW48613.1
CH471051 Genomic DNA Translation: EAW48614.1
RefSeqiNP_000726.1, NM_000735.3
UniGeneiHs.119689

Genome annotation databases

GeneIDi1081
KEGGihsa:1081
UCSCiuc003plj.3 human

Similar proteinsi

Entry informationi

Entry nameiQ6I9S8_HUMAN
AccessioniPrimary (citable) accession number: Q6I9S8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health