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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chainUniRule annotation
Gene namesi
Name:CGAImported
Synonyms:FSHAImported, GPA1Imported
ORF Names:hCG_33165Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_500845228525 – 116Glycoprotein hormones alpha chainUniRule annotationAdd BLAST92

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000135346.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000358595.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit alpha family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
HOVERGENiHBG000452.
KOiK08522.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6I9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60 70 80 90 100
QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV
110
ENHTACHCST CYYHKS
Length:116
Mass (Da):13,075
Last modified:May 10, 2005 - v1
Checksum:iF0623CD8CC90CFCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU081886 Genomic DNA. Translation: ABU96751.1.
FJ624079 mRNA. Translation: ACM91588.1.
AK311972 mRNA. Translation: BAG34911.1.
CR457427 mRNA. Translation: CAG33708.1.
HF564671 Genomic DNA. Translation: CCP37876.1.
CH471051 Genomic DNA. Translation: EAW48613.1.
CH471051 Genomic DNA. Translation: EAW48614.1.
RefSeqiNP_000726.1. NM_000735.3.
UniGeneiHs.119689.

Genome annotation databases

GeneIDi1081.
KEGGihsa:1081.
UCSCiuc003plj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU081886 Genomic DNA. Translation: ABU96751.1.
FJ624079 mRNA. Translation: ACM91588.1.
AK311972 mRNA. Translation: BAG34911.1.
CR457427 mRNA. Translation: CAG33708.1.
HF564671 Genomic DNA. Translation: CCP37876.1.
CH471051 Genomic DNA. Translation: EAW48613.1.
CH471051 Genomic DNA. Translation: EAW48614.1.
RefSeqiNP_000726.1. NM_000735.3.
UniGeneiHs.119689.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358595.

Protocols and materials databases

DNASUi1081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1081.
KEGGihsa:1081.
UCSCiuc003plj.3. human.

Organism-specific databases

CTDi1081.
PharmGKBiPA26433.

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
HOVERGENiHBG000452.
KOiK08522.

Miscellaneous databases

ChiTaRSiCGA. human.
GenomeRNAii1081.

Gene expression databases

BgeeiENSG00000135346.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6I9S8_HUMAN
AccessioniPrimary (citable) accession number: Q6I9S8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.