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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chainUniRule annotation
Gene namesi
Name:CGAImported
Synonyms:FSHAImported, GPA1Imported
ORF Names:hCG_33165Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000135346.8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501398377025 – 116Glycoprotein hormones alpha chainUniRule annotationAdd BLAST92

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000135346.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit alpha family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
HOVERGENiHBG000452.
KOiK08522.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiView protein in Pfam
PF00236. Hormone_6. 1 hit.
PRINTSiPR00274. GLYCOHORMONE.
SMARTiView protein in SMART
SM00067. GHA. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6I9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60 70 80 90 100
QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV
110
ENHTACHCST CYYHKS
Length:116
Mass (Da):13,075
Last modified:May 10, 2005 - v1
Checksum:iF0623CD8CC90CFCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU081886 Genomic DNA. Translation: ABU96751.1.
FJ624079 mRNA. Translation: ACM91588.1.
AK311972 mRNA. Translation: BAG34911.1.
CR457427 mRNA. Translation: CAG33708.1.
HF564671 Genomic DNA. Translation: CCP37876.1.
CH471051 Genomic DNA. Translation: EAW48613.1.
CH471051 Genomic DNA. Translation: EAW48614.1.
RefSeqiNP_000726.1. NM_000735.3.
UniGeneiHs.119689.

Genome annotation databases

GeneIDi1081.
KEGGihsa:1081.
UCSCiuc003plj.3. human.

Similar proteinsi

Entry informationi

Entry nameiQ6I9S8_HUMAN
AccessioniPrimary (citable) accession number: Q6I9S8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.