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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chainUniRule annotation
Gene namesi
Name:CGAImported
Synonyms:FSHAImported, GPA1Imported
ORF Names:hCG_33165Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_500845228525 – 116Glycoprotein hormones alpha chainUniRule annotationAdd BLAST92

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Proteomic databases

MaxQBiQ6I9S8.

Expressioni

Gene expression databases

BgeeiENSG00000135346.
ExpressionAtlasiQ6I9S8. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000358595.

Structurei

3D structure databases

SMRiQ6I9S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit alpha family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
HOVERGENiHBG000452.
KOiK08522.
PhylomeDBiQ6I9S8.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiView protein in Pfam
PF00236. Hormone_6. 1 hit.
PRINTSiPR00274. GLYCOHORMONE.
SMARTiView protein in SMART
SM00067. GHA. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6I9S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60 70 80 90 100
QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV
110
ENHTACHCST CYYHKS
Length:116
Mass (Da):13,075
Last modified:May 10, 2005 - v1
Checksum:iF0623CD8CC90CFCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU081886 Genomic DNA. Translation: ABU96751.1.
FJ624079 mRNA. Translation: ACM91588.1.
AK311972 mRNA. Translation: BAG34911.1.
CR457427 mRNA. Translation: CAG33708.1.
HF564671 Genomic DNA. Translation: CCP37876.1.
CH471051 Genomic DNA. Translation: EAW48613.1.
CH471051 Genomic DNA. Translation: EAW48614.1.
RefSeqiNP_000726.1. NM_000735.3.
UniGeneiHs.119689.

Genome annotation databases

GeneIDi1081.
KEGGihsa:1081.
UCSCiuc003plj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU081886 Genomic DNA. Translation: ABU96751.1.
FJ624079 mRNA. Translation: ACM91588.1.
AK311972 mRNA. Translation: BAG34911.1.
CR457427 mRNA. Translation: CAG33708.1.
HF564671 Genomic DNA. Translation: CCP37876.1.
CH471051 Genomic DNA. Translation: EAW48613.1.
CH471051 Genomic DNA. Translation: EAW48614.1.
RefSeqiNP_000726.1. NM_000735.3.
UniGeneiHs.119689.

3D structure databases

SMRiQ6I9S8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358595.

Proteomic databases

MaxQBiQ6I9S8.

Protocols and materials databases

DNASUi1081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1081.
KEGGihsa:1081.
UCSCiuc003plj.3. human.

Organism-specific databases

CTDi1081.
PharmGKBiPA26433.

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
HOVERGENiHBG000452.
KOiK08522.
PhylomeDBiQ6I9S8.

Miscellaneous databases

ChiTaRSiCGA. human.
GenomeRNAii1081.

Gene expression databases

BgeeiENSG00000135346.
ExpressionAtlasiQ6I9S8. baseline and differential.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiView protein in Pfam
PF00236. Hormone_6. 1 hit.
PRINTSiPR00274. GLYCOHORMONE.
SMARTiView protein in SMART
SM00067. GHA. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6I9S8_HUMAN
AccessioniPrimary (citable) accession number: Q6I9S8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 15, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.