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Protein

C-X-C motif chemokine

Gene

CXCL5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokineUniRule annotation
Gene namesi
Name:CXCL5Imported
ORF Names:hCG_16364Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000163735.6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35573

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36UniRule annotationAdd BLAST36
ChainiPRO_501420594237 – 114C-X-C motif chemokineUniRule annotationAdd BLAST78

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ6I9S7

Expressioni

Gene expression databases

BgeeiENSG00000163735
ExpressionAtlasiQ6I9S7 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S93EBI-10249885,EBI-945833

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6I9S7, 1 interactor

Structurei

3D structure databases

SMRiQ6I9S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 106SCYInterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J4TR Eukaryota
ENOG41117DC LUCA
HOVERGENiHBG107789
KOiK05506
OMAiLRCVCLQ
OrthoDBiEOG091G132U

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6I9S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV
60 70 80 90 100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK
110
KVIQKILDGG NKEN
Length:114
Mass (Da):11,972
Last modified:May 10, 2005 - v1
Checksum:i56B21EE86AE952D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006807 mRNA Translation: AAP35453.1
AC097709 Genomic DNA Translation: AAY41005.1
AK312128 mRNA Translation: BAG35064.1
CR457428 mRNA Translation: CAG33709.1
CH471057 Genomic DNA Translation: EAX05696.1
RefSeqiNP_002985.1, NM_002994.4
UniGeneiHs.89714

Genome annotation databases

GeneIDi6374
KEGGihsa:6374
UCSCiuc003hhk.5 human

Similar proteinsi

Entry informationi

Entry nameiQ6I9S7_HUMAN
AccessioniPrimary (citable) accession number: Q6I9S7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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