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Protein

C-X-C motif chemokine

Gene

CXCL5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokineUniRule annotation
Gene namesi
Name:CXCL5Imported
ORF Names:hCG_16364Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36UniRule annotationAdd BLAST36
ChainiPRO_500845228637 – 114C-X-C motif chemokineUniRule annotationAdd BLAST78

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000163735.
ExpressionAtlasiQ6I9S7. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ6I9S7. 1 interactor.
STRINGi9606.ENSP00000296027.

Structurei

3D structure databases

SMRiQ6I9S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 106SCYInterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
HOVERGENiHBG107789.
KOiK05506.
OMAiLRCVCLQ.
OrthoDBiEOG091G132U.
PhylomeDBiQ6I9S7.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6I9S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV
60 70 80 90 100
CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK
110
KVIQKILDGG NKEN
Length:114
Mass (Da):11,972
Last modified:May 10, 2005 - v1
Checksum:i56B21EE86AE952D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006807 mRNA. Translation: AAP35453.1.
AC097709 Genomic DNA. Translation: AAY41005.1.
AK312128 mRNA. Translation: BAG35064.1.
CR457428 mRNA. Translation: CAG33709.1.
CH471057 Genomic DNA. Translation: EAX05696.1.
RefSeqiNP_002985.1. NM_002994.4.
UniGeneiHs.89714.

Genome annotation databases

GeneIDi6374.
KEGGihsa:6374.
UCSCiuc003hhk.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT006807 mRNA. Translation: AAP35453.1.
AC097709 Genomic DNA. Translation: AAY41005.1.
AK312128 mRNA. Translation: BAG35064.1.
CR457428 mRNA. Translation: CAG33709.1.
CH471057 Genomic DNA. Translation: EAX05696.1.
RefSeqiNP_002985.1. NM_002994.4.
UniGeneiHs.89714.

3D structure databases

SMRiQ6I9S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6I9S7. 1 interactor.
STRINGi9606.ENSP00000296027.

Protocols and materials databases

DNASUi6374.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6374.
KEGGihsa:6374.
UCSCiuc003hhk.5. human.

Organism-specific databases

CTDi6374.
PharmGKBiPA35573.

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
HOVERGENiHBG107789.
KOiK05506.
OMAiLRCVCLQ.
OrthoDBiEOG091G132U.
PhylomeDBiQ6I9S7.

Miscellaneous databases

GenomeRNAii6374.

Gene expression databases

BgeeiENSG00000163735.
ExpressionAtlasiQ6I9S7. baseline and differential.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6I9S7_HUMAN
AccessioniPrimary (citable) accession number: Q6I9S7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: January 18, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.