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Protein
Submitted name:

Hepatocyte growth factor activator inhibitor-1

Gene

HAI-1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Protein family/group databases

MEROPSiI02.007

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor activator inhibitor-1Imported
Gene namesi
Name:HAI-1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei444 – 466HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500427448930 – 507Sequence analysisAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi313 ↔ 325PROSITE-ProRule annotation
Disulfide bondi320 ↔ 338PROSITE-ProRule annotation
Disulfide bondi332 ↔ 347PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ6I750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 134MANSCInterPro annotationAdd BLAST84
Domaini244 – 294BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini369 – 419BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
HOVERGENiHBG061664
PhylomeDBiQ6I750

Family and domain databases

CDDicd00109 KU, 2 hits
cd00112 LDLa, 1 hit
Gene3Di2.60.40.10, 1 hit
4.10.410.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR013980 MANSC_dom
IPR011106 MANSC_N
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 2 hits
PF00057 Ldl_recept_a, 1 hit
PF07502 MANEC, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 2 hits
SM00192 LDLa, 1 hit
SM00765 MANEC, 1 hit
SUPFAMiSSF57362 SSF57362, 2 hits
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 2 hits
PS50279 BPTI_KUNITZ_2, 2 hits
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS50986 MANSC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6I750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRLAQAS ISTACVWLLC ALGLQGTETE LPSAPPEFSG GAACLNRFTS
60 70 80 90 100
GVPAFVLDTE ASVSNGATFL GSPTVHRGWD CVRACCTTQN CNLALVELQP
110 120 130 140 150
DGGEDAISAC FLMNCLYEQN FVCKFAPKDG FINYLTQDLY NSYRELRTRG
160 170 180 190 200
FGGSRIPRIW MGIDLKVQLQ KPLVLRDADN TDWHLLQGDQ DVSVKRNHPE
210 220 230 240 250
EVELWGLKEG TYLFQLTRTD SDQLEETVNL TITVLTAEQT EDYCLASYKV
260 270 280 290 300
GRCRGSFPRW YYDPKEQICK SFTFGGCLGN KNNYLREEEC MLACKDVKGI
310 320 330 340 350
SPKRHHPVCT GSCHSTQFQC SNGCCIDGFL ECDDTPDCPD GSDEATCEKY
360 370 380 390 400
SSGFDELQSI HFLSDKGYCA ELPDTGFCKE NIPRWYYNPF SERCARFTYG
410 420 430 440 450
GCYGNKNNFE KEQQCLESCR GISKKDVFGL RRESSVPSAG SVEVAIAVLL
460 470 480 490 500
AVCIIVVLTI LGYCFFKNQK KNFHSPLHQP PPTPASSTVS TTEDTEHLVY

NHTTQPL
Length:507
Mass (Da):56,470
Last modified:July 19, 2004 - v1
Checksum:i810043AE28C47AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154834 mRNA Translation: BAD23971.1
UniGeneiRn.44189

Genome annotation databases

UCSCiRGD:1303138 rat

Similar proteinsi

Entry informationi

Entry nameiQ6I750_RAT
AccessioniPrimary (citable) accession number: Q6I750
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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