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Protein
Submitted name:

Hepatocyte growth factor activator inhibitor-1

Gene

Spint1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

Protein family/group databases

MEROPSiI02.007.

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor activator inhibitor-1Imported
Gene namesi
Name:Spint1Imported
Synonyms:HAI-1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1303138. Spint1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei444 – 466HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500427448930 – 507Sequence analysisAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi313 ↔ 325PROSITE-ProRule annotation
Disulfide bondi320 ↔ 338PROSITE-ProRule annotation
Disulfide bondi332 ↔ 347PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ6I750.

Structurei

3D structure databases

ProteinModelPortaliQ6I750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 134MANSCInterPro annotationAdd BLAST84
Domaini244 – 294BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini369 – 419BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
HOVERGENiHBG061664.
PhylomeDBiQ6I750.

Family and domain databases

CDDicd00109. KU. 2 hits.
cd00112. LDLa. 1 hit.
Gene3Di2.60.40.10. 1 hit.
4.10.410.10. 2 hits.
InterProiView protein in InterPro
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR036055. LDL_receptor-like_sf.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR013980. MANSC_dom.
IPR011106. MANSC_N.
IPR020901. Prtase_inh_Kunz-CS.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 2 hits.
PF00057. Ldl_recept_a. 1 hit.
PF07502. MANEC. 1 hit.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 2 hits.
SM00192. LDLa. 1 hit.
SM00765. MANEC. 1 hit.
SUPFAMiSSF57362. SSF57362. 2 hits.
SSF57424. SSF57424. 1 hit.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS50986. MANSC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6I750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRLAQAS ISTACVWLLC ALGLQGTETE LPSAPPEFSG GAACLNRFTS
60 70 80 90 100
GVPAFVLDTE ASVSNGATFL GSPTVHRGWD CVRACCTTQN CNLALVELQP
110 120 130 140 150
DGGEDAISAC FLMNCLYEQN FVCKFAPKDG FINYLTQDLY NSYRELRTRG
160 170 180 190 200
FGGSRIPRIW MGIDLKVQLQ KPLVLRDADN TDWHLLQGDQ DVSVKRNHPE
210 220 230 240 250
EVELWGLKEG TYLFQLTRTD SDQLEETVNL TITVLTAEQT EDYCLASYKV
260 270 280 290 300
GRCRGSFPRW YYDPKEQICK SFTFGGCLGN KNNYLREEEC MLACKDVKGI
310 320 330 340 350
SPKRHHPVCT GSCHSTQFQC SNGCCIDGFL ECDDTPDCPD GSDEATCEKY
360 370 380 390 400
SSGFDELQSI HFLSDKGYCA ELPDTGFCKE NIPRWYYNPF SERCARFTYG
410 420 430 440 450
GCYGNKNNFE KEQQCLESCR GISKKDVFGL RRESSVPSAG SVEVAIAVLL
460 470 480 490 500
AVCIIVVLTI LGYCFFKNQK KNFHSPLHQP PPTPASSTVS TTEDTEHLVY

NHTTQPL
Length:507
Mass (Da):56,470
Last modified:July 19, 2004 - v1
Checksum:i810043AE28C47AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154834 mRNA. Translation: BAD23971.1.
UniGeneiRn.44189.

Genome annotation databases

UCSCiRGD:1303138. rat.

Similar proteinsi

Entry informationi

Entry nameiQ6I750_RAT
AccessioniPrimary (citable) accession number: Q6I750
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)