Reviewed, UniProtKB/Swiss-Prot Q6HPB7 (UPPP1_BACHK)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Synonyms:	bacA
Ordered Locus Names:	BT9727_0251

Organism

Bacillus thuringiensis subsp. konkukian [Complete proteome] [HAMAP]

Taxonomic identifier

180856 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151101
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	42 – 62	21	Potential
	Transmembrane	84 – 104	21	Potential
	Transmembrane	108 – 128	21	Potential
	Transmembrane	184 – 204	21	Potential
	Transmembrane	217 – 237	21	Potential
	Transmembrane	245 – 265	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6HPB7-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 17DF0F7418A55BC8	FASTA	265	29,046
	10 20 30 40 50 60 MSDIITAFIL GIVEGLAEFL PISSTGHLIL VGHLLGFEGE RAKTFEIVIQ LGAILAIAIL 70 80 90 100 110 120 YHKRLVSLCN IKPLLRKEKK FNAFHVFLGV FPAVVAGLLL HDIIKTYLFQ PYTVVIGLVA 130 140 150 160 170 180 GAILMIFAEV KKQEATSYSL DDLTYRQALT IGLFQCLAVY PGFSRAGSTI SGGLLAKVNY 190 200 210 220 230 240 KTASEFSFLI ALPVMVGATG LDLLKSWTYL SVDDIPMFAV GFITSFIVAM LAVVTFLKLL 250 260 EKIGLKPFAY YRILLAILFT VFVLL

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017355 Genomic DNA. Translation: AAT58966.1.
RefSeq	YP_034603.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2854004.
GenomeReviews	Gene locus BT9727_0251 in contig AE017355_GR.
KEGG	btk:BT9727_0251.
NMPDR	fig|281309.1.peg.243.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6HPB7.
OMA	KPFAYYR.
Enzyme and pathway databases
BioCyc	BTHU281309:BT9727_0251-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_BACHK

Accession

Primary (citable) accession number: Q6HPB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)