Reviewed, UniProtKB/Swiss-Prot Q6HP28 (OTCC_BACHK)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	BT9727_0342

Organism

Bacillus thuringiensis subsp. konkukian [Complete proteome] [HAMAP]

Taxonomic identifier

180856 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112883
Regions
	Region	60 – 64	5	Carbamoyl phosphate binding By similarity
	Region	270 – 273	4	Ornithine binding By similarity
Sites
	Binding site	111	1	Carbamoyl phosphate By similarity
	Binding site	138	1	Carbamoyl phosphate By similarity
	Site	35	1	Important for structural integrity By similarity
	Site	151	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6HP28-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 6442572EC44015C1	FASTA	332	37,447
	10 20 30 40 50 60 MLMTRPNLKG RSFLAEKDFT PEELLYFLDL AAELKEKKKN GIPHHYLEGK NVALLFEKTS 70 80 90 100 110 120 TRTRCAFTVA CTDLGANPEY LGKGDIQLGK KESVEDTAKV LGRMFDGIEF RGFNHETVES 130 140 150 160 170 180 LAQNSGVPVW NGLTDMWHPT QTLADLLTIR EHVGKLKNVK LVYVGDGRNN VANSLLVGGA 190 200 210 220 230 240 IVGMDVRICT PESLWPAQEV IDLAKKYNEQ VMITSNVEEA VASADVIYTD VWVSMGEEEK 250 260 270 280 290 300 FAERVELLKP YQVNMKMIKE TGNKNVIFLH CLPAFHDVET MYGEEVYEKY GLKEMEVTDE 310 320 330 VFRSKHSKVF DQAENRMHTI KAVMAATLGN ME

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017355 Genomic DNA. Translation: AAT58998.1.
RefSeq	YP_034692.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2858335.
GenomeReviews	Gene locus BT9727_0342 in contig AE017355_GR.
KEGG	btk:BT9727_0342.
NMPDR	fig|281309.1.peg.332.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6HP28.
OMA	FRSKHSK.
Enzyme and pathway databases
BioCyc	BTHU281309:BT9727_0342-MON.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_BACHK

Accession

Primary (citable) accession number: Q6HP28

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)