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Protein

Ferrochelatase 2

Gene

hemH2

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase 2 (hemH2), Ferrochelatase 1 (hemH1)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi181IronUniRule annotation1
Metal bindingi262IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase 2UniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthase 2UniRule annotation
Protoheme ferro-lyase 2UniRule annotation
Gene namesi
Name:hemH2UniRule annotation
Ordered Locus Names:BT9727_1056
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001301 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751121 – 319Ferrochelatase 2Add BLAST319

Structurei

3D structure databases

ProteinModelPortaliQ6HM28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000060729.
KOiK01772.
OMAiNNIFTEY.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6HM28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKKIGLLV MAYGTPDSLD EVEAYYTHIR HGRKPSEEAL QDLIGRYKAI
60 70 80 90 100
GGISPLAKIT KEQAHKLTDS MNNMFTEYEF NCYLGLKHTA PFIEDAVEEM
110 120 130 140 150
KRDGIEQAIS IVLAPHYSTF SIKAYNERAI RLSEEIGGPV IEPIDQWYDE
160 170 180 190 200
PKFISYWADQ IKETFTKIED NEKAVVIFSA HSLPEKIIAA GDPYVEQLQY
210 220 230 240 250
TADLIAAAAN IQNYTIGWQS AGNTSDSWIG PDVQDLTRDL FEEHRYESFI
260 270 280 290 300
YCPVGFVAEH LEVLYDNDYE CKVVTDELNA AYFRPTMPNA QSTFIDCLAT
310
IVSRKMKEIV DKELILNNN
Length:319
Mass (Da):36,320
Last modified:July 19, 2004 - v1
Checksum:iCB3C6D21AFB356F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT62227.1.
RefSeqiWP_000727368.1. NC_005957.1.
YP_035393.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT62227; AAT62227; BT9727_1056.
GeneIDi2855309.
KEGGibtk:BT9727_1056.
PATRICi18982759. VBIBacThu119411_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT62227.1.
RefSeqiWP_000727368.1. NC_005957.1.
YP_035393.1. NC_005957.1.

3D structure databases

ProteinModelPortaliQ6HM28.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT62227; AAT62227; BT9727_1056.
GeneIDi2855309.
KEGGibtk:BT9727_1056.
PATRICi18982759. VBIBacThu119411_1110.

Phylogenomic databases

HOGENOMiHOG000060729.
KOiK01772.
OMAiNNIFTEY.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH2_BACHK
AccessioniPrimary (citable) accession number: Q6HM28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.