Reviewed, UniProtKB/Swiss-Prot Q6HL58 (KCY_BACHK)

Names and origin

Protein names

Recommended name:
    Cytidylate kinase
      Short name=CK
    EC=2.7.4.14
Alternative name(s):
    Cytidine monophosphate kinase
      Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BT9727_1379

Organism

Bacillus thuringiensis subsp. konkukian [Complete proteome] [HAMAP]

Taxonomic identifier

180856 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Cytidylate kinase HAMAP MF_00238		PRO_0000131878
Regions
	Nucleotide binding	11 – 19	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6HL58-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 9036B5383404125B	FASTA	225	25,259
	10 20 30 40 50 60 MDKRISIAID GPAAAGKSTV AKVVAKKLSY VYIDTGAMYR TITYAALEQK VDIENEEQLM 70 80 90 100 110 120 EVVKNVKIEF QQGENTQLVF LNGQDVSEVI RTPEVTNRVS IVAKHRLVRE EMVRRQQELA 130 140 150 160 170 180 EKGGVVMDGR DIGTHVLPDA EVKIFMLASV EERAERRHLE NMNKGFDSNL EQLKEEIAQR 190 200 210 220 DKLDSEREVS PLKKADDALE LDTTSLSIEE VVQKIMGIVS GVFAK

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017355 Genomic DNA. Translation: AAT63236.1.
RefSeq	YP_035713.1.
3D structure databases
SMR	Q6HL58. Positions 3-220.
ModBase	Search...
Genome annotation databases
GeneID	2858539.
GenomeReviews	Gene locus BT9727_1379 in contig AE017355_GR.
KEGG	btk:BT9727_1379.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG354377.
OMA	DTGLLYR.
Enzyme and pathway databases
BioCyc	BTHU281309:BT9727_1379-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BACHK

Accession

Primary (citable) accession number: Q6HL58

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)