Q6HKG3 (SDHD_BACHK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable D-serine dehydratase
EC=4.3.1.18

Alternative name(s):
D-serine deaminase
Short name=DSD

Gene names

Name:	dsdA
Ordered Locus Names:	BT9727_1631

Organism

Bacillus thuringiensis subsp. konkukian (strain 97-27) [Complete proteome] [HAMAP]

Taxonomic identifier

281309 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus thuringiensis › Bacillus thuringiensis subsp. konkukian

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP-Rule MF_01030
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC hydro-lyase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Probable D-serine dehydratase HAMAP-Rule MF_01030		PRO_0000185605
Amino acid modifications
	Modified residue	116	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6HKG3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 29144A49497031AE	FASTA	446	49,453
	10 20 30 40 50 60 MKEIEKLKEE YPLLNKLIAT EEVFWVNPNM EKYETAIKDS PLSEENVKDA EERLKRFASY 70 80 90 100 110 120 IAKVFPETKE TKGIIESPLL KIPSMKQALE KNYEQPILGE LLLKCDSHLP ISGSIKARGG 130 140 150 160 170 180 IYEVLKHAEQ LALQHGMLTE EDNYAILDSD TCREFFATYS IAVGSTGNLG LSIGIMSAKL 190 200 210 220 230 240 GFNVTVHMSA DAKQWKKDLL RSKGVNVIEY EADYSKAVEE GRRQADADPS CYFVDDENSH 250 260 270 280 290 300 DLFLGYAVAA SRLQKQLEEL KIVVDEEHPL FVYLPCGVGG GPGGVAFGLK LLYKDNVHCF 310 320 330 340 350 360 FAEPTHSPCM LIGLMTGLHD KIAVQDIGID NVTDADGLAV GRPSGFVGKT MEPFLSGNYT 370 380 390 400 410 420 VSDEELYRLL KELADTENIY LEPSALAGMI GPVKVCKEDA YLQKQQLMEK VQKGTHIVWG 430 440 TGGSMVPEDV MNGYYKTGEA LTILEK

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017355 Genomic DNA. Translation: AAT63288.1.
RefSeq	YP_035963.1. NC_005957.1.
3D structure databases
ProteinModelPortal	Q6HKG3.
ModBase	Search...
Protein-protein interaction databases
STRING	281309.BT9727_1631.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT63288; AAT63288; BT9727_1631.
GeneID	2854131.
KEGG	btk:BT9727_1631.
PATRIC	18983975. VBIBacThu119411_1717.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3048.
HOGENOM	HOG000218072.
KO	K01753.
OMA	HCLFAEP.
ProtClustDB	PRK02991.
Enzyme and pathway databases
BioCyc	BTHU281309:GJID-1717-MONOMER.
Family and domain databases
HAMAP	MF_01030. D-Ser_dehydrat.
InterPro	IPR011780. D_Ser_am_lyase. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. [Graphical view]
PANTHER	PTHR10314:SF9. PTHR10314:SF9. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD_BACHK

Accession

Primary (citable) accession number: Q6HKG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program