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Q6HJK9

- FTHS_BACHK

UniProt

Q6HJK9 - FTHS_BACHK

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHU281309:GJID-2021-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BT9727_1938
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001301: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_0000199332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281309.BT9727_1938.

Structurei

3D structure databases

ProteinModelPortaliQ6HJK9.
SMRiQ6HJK9. Positions 10-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6HJK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTTTTVKSD IEIAQEASMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI
60 70 80 90 100
FKRLQNEKDG KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR
110 120 130 140 150
EPSLGPTMGL KGGAAGGGFS QVVPMEDINL HFTGDIHAIT TANNALAAFI
160 170 180 190 200
DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL RNVVIGLGGP VQGVPREDGF
210 220 230 240 250
DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT VKDLGVEGAL
260 270 280 290 300
TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY
310 320 330 340 350
VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ
360 370 380 390 400
LKEENVDALA KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVAYLQE
410 420 430 440 450
WCNERGYAVS LTEVWEKGGQ GGVDLAEKVL KEIEKGENNY APLYELELPL
460 470 480 490 500
EEKIRTIAQK VYGAKDIEFA PKARKQLAQY EGEGWSNLPI CMAKTQYSLS
510 520 530 540 550
DDATKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG LPKQPAALQM
560
DVNEDGKAVG LF
Length:562
Mass (Da):60,462
Last modified:July 19, 2004 - v1
Checksum:i3E8BBBD4C8D76E69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017355 Genomic DNA. Translation: AAT63477.1.
RefSeqiYP_036267.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT63477; AAT63477; BT9727_1938.
GeneIDi2856680.
KEGGibtk:BT9727_1938.
PATRICi18984617. VBIBacThu119411_2037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017355 Genomic DNA. Translation: AAT63477.1 .
RefSeqi YP_036267.1. NC_005957.1.

3D structure databases

ProteinModelPortali Q6HJK9.
SMRi Q6HJK9. Positions 10-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281309.BT9727_1938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT63477 ; AAT63477 ; BT9727_1938 .
GeneIDi 2856680.
KEGGi btk:BT9727_1938.
PATRICi 18984617. VBIBacThu119411_2037.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BTHU281309:GJID-2021-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 97-27.

Entry informationi

Entry nameiFTHS_BACHK
AccessioniPrimary (citable) accession number: Q6HJK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3