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Protein

Kynurenine formamidase

Gene

kynB

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arylformamidase activity Source: UniProtKB
  2. formamidase activity Source: InterPro

GO - Biological processi

  1. anthranilate metabolic process Source: UniProtKB
  2. tryptophan catabolic process to kynurenine Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tryptophan catabolism

Enzyme and pathway databases

BioCyciBTHU281309:GJID-2602-MONOMER.
UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:BT9727_2522
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001301: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Kynurenine formamidasePRO_0000362093Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281309.BT9727_2522.

Structurei

3D structure databases

ProteinModelPortaliQ6HHX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1878.
HOGENOMiHOG000219455.
KOiK07130.
OMAiTLWDITP.
OrthoDBiEOG67T5JJ.

Family and domain databases

HAMAPiMF_01969. KynB.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6HHX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSEWIDIS QPLNNDIATW PGDTPFSYEV SWSKEESGSV NVGKLTMSIH
60 70 80 90 100
TGTHIDAPFH FDNNGKKVLD LDIQVYVGPT RIIDVSNLES IGKKELEKFH
110 120 130 140 150
LEGVERLLLR TSSHGKANEF PDIIPHLRAD IAPFLSEKGI RLIGVDVPSV
160 170 180 190 200
DPLDDKELAA HHQLFKHGIH ILENVVLDHV ADGDYELIAL PLALSDADGS

PVRAVIKPI
Length:209
Mass (Da):23,104
Last modified:July 19, 2004 - v1
Checksum:i757CC1F2F68A0975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT61841.1.
RefSeqiWP_000858066.1. NC_005957.1.
YP_036848.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT61841; AAT61841; BT9727_2522.
GeneIDi2857285.
KEGGibtk:BT9727_2522.
PATRICi18985887. VBIBacThu119411_2670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT61841.1.
RefSeqiWP_000858066.1. NC_005957.1.
YP_036848.1. NC_005957.1.

3D structure databases

ProteinModelPortaliQ6HHX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi281309.BT9727_2522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT61841; AAT61841; BT9727_2522.
GeneIDi2857285.
KEGGibtk:BT9727_2522.
PATRICi18985887. VBIBacThu119411_2670.

Phylogenomic databases

eggNOGiCOG1878.
HOGENOMiHOG000219455.
KOiK07130.
OMAiTLWDITP.
OrthoDBiEOG67T5JJ.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.
BioCyciBTHU281309:GJID-2602-MONOMER.

Family and domain databases

HAMAPiMF_01969. KynB.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 97-27.

Entry informationi

Entry nameiKYNB_BACHK
AccessioniPrimary (citable) accession number: Q6HHX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.