Q6HHF5 (AROC2_BACHK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase 2
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase 2

Gene names

Name:	aroC2
Ordered Locus Names:	BT9727_2697

Organism

Bacillus thuringiensis subsp. konkukian (strain 97-27) [Complete proteome] [HAMAP]

Taxonomic identifier

281309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Chorismate synthase 2 HAMAP MF_00300		PRO_0000140550

Sequences

	Sequence		Length	Mass (Da)
	Q6HHF5 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 6F2FAAC8DBF47A1E	FASTA	390	42,379
	10 20 30 40 50 60 MRYITAGESH GPQLTVILEG VPAGLTLAAE HINKELLRRQ KGHGRGRRMQ IETDTVEIVS 70 80 90 100 110 120 GVRHGMTLGS PITLIVKNDD FKHWTKVMGA EPISEKESKE MKRTITKPRP GHADLNGAIK 130 140 150 160 170 180 YGHRDIRNVL ERSSARETTV RVAAGAVAKQ ILKELGVEIA GHVLEIGGVK AKHISNLSIE 190 200 210 220 230 240 EIQIITENSP VRCLDKTVEQ EMMDAIDNAK SSGDSIGGIV EVIAEGMPIG VGSYVHYDRK 250 260 270 280 290 300 LDAKLAGAIM SINAFKGAEI GVGFEAARQP GSKVHDEILW DEEQGYTRKT NNAGGLEGGM 310 320 330 340 350 360 TTGMPIVVRG VMKPIPTLYK PLASVDIDTK EAFQASIERS DSCAVPAAGV VAESVVAWEL 370 380 390 AHALVEQFGK DRMELIQQNI TQHNKYAKEF

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017355 Genomic DNA. Translation: AAT61253.1.
RefSeq	YP_037021.1. NC_005957.1.
3D structure databases
ProteinModelPortal	Q6HHF5.
SMR	Q6HHF5. Positions 1-390.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000073591; EBBACP00000071677; EBBACG00000073582.
GeneID	2857963.
GenomeReviews	Gene locus BT9727_2697 in contig AE017355_GR.
KEGG	btk:BT9727_2697.
NMPDR	fig|281309.1.peg.2661.
PATRIC	18986273. VBIBacThu119411_2863.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002373.
HOGENOM	HBG292336.
OMA	IQTITEN.
ProtClustDB	PRK12463.
Enzyme and pathway databases
BioCyc	BTHU281309:BT9727_2697-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC2_BACHK

Accession

Primary (citable) accession number: Q6HHF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program