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Q6HG59 (DXR1_BACHK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1

Short name=DXP reductoisomerase 1
EC=1.1.1.267
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase 1
2-C-methyl-D-erythritol 4-phosphate synthase 1
Gene names
Name:dxr1
Ordered Locus Names:BT9727_3144
OrganismBacillus thuringiensis subsp. konkukian (strain 97-27) [Complete proteome] [HAMAP]
Taxonomic identifier281309 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity. HAMAP MF_00183

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3853851-deoxy-D-xylulose 5-phosphate reductoisomerase 1 HAMAP MF_00183
PRO_0000163611

Regions

Nucleotide binding8 – 3730NADP By similarity

Sites

Metal binding1481Divalent metal cation By similarity
Metal binding1501Divalent metal cation By similarity
Metal binding2191Divalent metal cation By similarity
Binding site1231Substrate By similarity
Binding site1501Substrate By similarity
Binding site1741Substrate By similarity
Binding site1971Substrate By similarity
Binding site2191Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6HG59 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 65DA0CDC461F8AA3

FASTA38542,546
        10         20         30         40         50         60 
MVKYISILGS TGSIGTSALD VVSAHPEHFK IVGLTANYNI ELLEQQIKTF QPRIVSVATK 

        70         80         90        100        110        120 
ELADTLRTRI STNTKITYGT DGLIAVATHP NSNLVLSSVV GVSGLLPTIE ALKAKKDIAI 

       130        140        150        160        170        180 
ANKETLVAAG HIVTELAKQN GCRLIPVDSE HSAIFQCLNG ENNKEIDKLI VTASGGAFRD 

       190        200        210        220        230        240 
KTREEMKTLQ AKDALKHPNW LMGAKLTIDS ATLMNKGFEV MEARWLFDIP YEKIDVMIHK 

       250        260        270        280        290        300 
ESIIHSLVEF IDGSVIAQLG APDMRMPIQY AFHYPTRLPS SYEKLNLLEI GSLHFEKPDL 

       310        320        330        340        350        360 
EKFPCLQYAY ECGKIGGTTP AVLNAANEIA NALFLKNEIA FFDIEKTIYK TVEAHHNVKD 

       370        380 
PSLDAILEAD QWARQYANQL LIKKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017355 Genomic DNA. Translation: AAT62181.1.
RefSeqYP_037467.1. NC_005957.1.

3D structure databases

ProteinModelPortalQ6HG59.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000075147; EBBACP00000073233; EBBACG00000075138.
GeneID2857981.
GenomeReviewsGene locus BT9727_3144 in contig AE017355_GR.
KEGGbtk:BT9727_3144.
NMPDRfig|281309.1.peg.3107.
PATRIC18987242. VBIBacThu119411_3347.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000001768.
HOGENOMHBG430762.
OMAIAKLYIT.
ProtClustDBPRK12464.

Enzyme and pathway databases

BioCycBTHU281309:BT9727_3144-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDXR1_BACHK
AccessionPrimary (citable) accession number: Q6HG59
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families