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Q6HEX4 (TRMD_BACHK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase
EC=2.1.1.228
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene names
Name:trmD
Ordered Locus Names:BT9727_3582
OrganismBacillus thuringiensis subsp. konkukian (strain 97-27) [Complete proteome] [HAMAP]
Taxonomic identifier281309 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. HAMAP MF_00605

Subunit structure

Homodimer By similarity. HAMAP MF_00605

Subcellular location

Cytoplasm Potential HAMAP MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
PRO_0000060327

Regions

Region133 – 1386S-adenosyl-L-methionine binding By similarity

Sites

Binding site1131S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6HEX4 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 189A1172EE62AC09

FASTA24427,967
        10         20         30         40         50         60 
MKIDILTLFP DMFTGVFGSS ILKKAQEKEA VELRVVNFRD YTTSKHNSVD DYPYGGGAGM 

        70         80         90        100        110        120 
VLTPQPIFDA VEDLTKETER KPRVVLMCPQ GERFTQKKAE ELAEEEHLIF VCGHYEGYDE 

       130        140        150        160        170        180 
RIREHLVTDE ISIGDYVLTG GELASMVITD SVVRLLPGVL GNHASQVEDS FSTGLLEHPH 

       190        200        210        220        230        240 
YTRPADFRGM KVPDVLMSGN HKNIDEWRHK ESLRRTYTRR PDLLEERELS KQEKKWLEQI 


KEGK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017355 Genomic DNA. Translation: AAT60611.1.
RefSeqYP_037902.1. NC_005957.1.

3D structure databases

ProteinModelPortalQ6HEX4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000075166; EBBACP00000073252; EBBACG00000075157.
GeneID2858017.
GenomeReviewsGene locus BT9727_3582 in contig AE017355_GR.
KEGGbtk:BT9727_3582.
PATRIC18988188. VBIBacThu119411_3820.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000001149.
HOGENOMHBG285805.
OMAVCGRFEG.
ProtClustDBPRK00026.

Enzyme and pathway databases

BioCycBTHU281309:BT9727_3582-MONOMER.

Family and domain databases

HAMAPMF_00605. TrmD.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
[Graphical view]
Gene3DG3DSA:1.10.1270.20. tRNA_m1G_MeTrfase_C. 1 hit.
KOK00554.
PANTHERPTHR10056. PTHR10056. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFPIRSF000386. tRNA_mtase. 1 hit.
TIGRFAMsTIGR00088. TrmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_BACHK
AccessionPrimary (citable) accession number: Q6HEX4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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