Reviewed,
UniProtKB/Swiss-Prot Q6HEQ2 (MURD_BACHK)
Last modified
February 9, 2010.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-N-acetylmuramoylalanine--D-glutamate ligase EC=6.3.2.9 Alternative name(s): UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase D-glutamic acid-adding enzyme | ||||
| Gene names |
| ||||
| Organism | Bacillus thuringiensis subsp. konkukian [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 180856 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 450 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 |
| Catalytic activity | ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00639. |
| Sequence similarities | Belongs to the murCDEF family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organizationInferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic processInferred from electronic annotation. Source: HAMAP regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramoylalanine-D-glutamate ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 450 | 450 | UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 | PRO_0000108967 | |||||
Regions | |||||||||
| Nucleotide binding | 119 – 125 | 7 | ATP Potential | ||||||
Sequences
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References
| [1] | "Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. Gilna P.J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017355 Genomic DNA. Translation: AAT61588.1. |
| RefSeq | YP_037974.1. |
3D structure databases | |
| SMR | Q6HEQ2. Positions 5-449. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2857824. |
| GenomeReviews | Gene locus BT9727_3654 in contig AE017355_GR. |
| KEGG | btk:BT9727_3654. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG750024. |
| OMA | VKYYNDS. |
Enzyme and pathway databases | |
| BioCyc | BTHU281309:BT9727_3654-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00639. MurD. [Tree] |
| InterPro | IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR016040. NAD(P)-bd_dom. IPR005762. UDP-N-AcMur-Glu_ligase. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01087. murD. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MURD_BACHK | ||||||||
| Accession | Primary (citable) accession number: Q6HEQ2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


