Reviewed, UniProtKB/Swiss-Prot Q6HDI5 (PSD_BACHK)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BT9727_4073

Organism

Bacillus thuringiensis subsp. konkukian [Complete proteome] [HAMAP]

Taxonomic identifier

180856 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00662
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00662
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00662
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029629
	Chain	226 – 262	37	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029630
Sites
	Site	225 – 226	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	226	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6HDI5-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: D5BF4B1B59C8D071	FASTA	262	29,942
	10 20 30 40 50 60 MRRTLYRLMI ELTNGRFTSY ILRKFAQSRL SSIIIPSYVK VFQINQDEME KGLKEYRTLH 70 80 90 100 110 120 ELFTRKLKEG KRSIDTDASS IVSPVDGVFA DYGPIEDAKT FDIKGKRYSI VDMLGNEERA 130 140 150 160 170 180 QRYAGGTYMV IYLSPSHYHR IHSPLSGSVT ERFVLGRKSY PVNAAGMEYG KEPLSKNYRS 190 200 210 220 230 240 VTEVNSDGEH MALVKVGAMF VNSIELLHER DTVQKGEEMA YFTFGSTVVL LFEKDMIEVV 250 260 QELKSGQELR LGEKIATRLA HK

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017355 Genomic DNA. Translation: AAT63599.1.
RefSeq	YP_038391.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2855343.
GenomeReviews	Gene locus BT9727_4073 in contig AE017355_GR.
KEGG	btk:BT9727_4073.
NMPDR	fig|281309.1.peg.4031.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG302256.
OMA	ALFSVNP.
Enzyme and pathway databases
BioCyc	BTHU281309:BT9727_4073-MONOMER.
Family and domain databases
HAMAP	MF_00662. PS_decarb_type1. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BACHK

Accession

Primary (citable) accession number: Q6HDI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)