Reviewed, UniProtKB/Swiss-Prot Q6HBX6 (FENR2_BACHK)

Names and origin

Protein names

Recommended name:
    Ferredoxin--NADP reductase 2
      Short name=Fd-NADP+ reductase 2
      Short name=FNR 2
    EC=1.18.1.2

Gene names

Ordered Locus Names:

BT9727_4639

Organism

Bacillus thuringiensis subsp. konkukian [Complete proteome] [HAMAP]

Taxonomic identifier

180856 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_01685
Subunit structure	Homodimer By similarity. HAMAP MF_01685
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: HAMAP NADP or NADPH binding Inferred from electronic annotation. Source: HAMAP ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Ferredoxin--NADP reductase 2 HAMAP MF_01685		PRO_0000364805
Sites
	Binding site	20	1	FAD By similarity
	Binding site	39	1	FAD By similarity
	Binding site	47	1	FAD By similarity
	Binding site	52	1	FAD By similarity
	Binding site	92	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	126	1	FAD; via amide nitrogen By similarity
	Binding site	287	1	FAD By similarity
	Binding site	328	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6HBX6-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 9539B7A18B6378B7	FASTA	331	36,721
	10 20 30 40 50 60 MKVAENQKVY DITIIGGGPT GLFTAFYGGM RQASVKIIES LPQLGGQLSA LYPEKYIYDV 70 80 90 100 110 120 AGFPKVRAQE LVDNLKEQMK KFDPTVCLEE AVDTLEKQAD GIFKLVTNKQ THYSKSVIIT 130 140 150 160 170 180 AGNGAFQPRR LELEGTAKYE KKNLHYFVDD MNKFAGKRVV VFGGGDSAVD WTMMLEPIAD 190 200 210 220 230 240 KVTIVHRRDK FRAHEHSVES LMNSRAEVST PYVPVELIGD DKIEQVVLQH VKTEEKIIID 250 260 270 280 290 300 VDDVIVNYGF VSSLGPIKNW GLDIQKNSIL VNSKMETNIP GIYAAGDICT YEGKVKLIAC 310 320 330 GFGEAPTAVN NAKAYFDPNA KLQPMHSSSM F

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017355 Genomic DNA. Translation: AAT63212.1.
RefSeq	YP_038950.1.
3D structure databases
SMR	Q6HBX6. Positions 9-330.
ModBase	Search...
Genome annotation databases
GeneID	2858766.
GenomeReviews	Gene locus BT9727_4639 in contig AE017355_GR.
KEGG	btk:BT9727_4639.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	IYLVHRR.
Enzyme and pathway databases
BioCyc	BTHU281309:BT9727_4639-MONOMER.
Family and domain databases
HAMAP	MF_01685. FENR2. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR2_BACHK

Accession

Primary (citable) accession number: Q6HBX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)