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Q6HBR6

- GCSH_BACHK

UniProt

Q6HBR6 - GCSH_BACHK

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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
  2. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Enzyme and pathway databases

BioCyciBTHU281309:GJID-4791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Alternative name(s):
Octanoyl/lipoyl carrier proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:BT9727_4700
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001301: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. glycine cleavage complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Glycine cleavage system H proteinPRO_0000302350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631N6-lipoyllysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi281309.BT9727_4700.

Structurei

3D structure databases

ProteinModelPortaliQ6HBR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiCOG0509.
HOGENOMiHOG000239392.
KOiK02437.
OMAiADEYTAF.
OrthoDBiEOG60CWTC.

Family and domain databases

HAMAPiMF_00272. GcvH.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiPF01597. GCV_H. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6HBR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIPNNLRYS EEHEWVKTEG NEVVIGITHF AQNELGDIVF VELPEVGATI
60 70 80 90 100
EADEPFGSVE SVKTVSELYA PVSGKVVAVN EELSDQPELV NESPYEGAWM
110 120
VKVELSDASQ VEKLLTAEKY AEMTNQD
Length:127
Mass (Da):14,045
Last modified:July 19, 2004 - v1
Checksum:i523CA49E2A520C14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017355 Genomic DNA. Translation: AAT62561.1.
RefSeqiYP_039010.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT62561; AAT62561; BT9727_4700.
GeneIDi2853657.
KEGGibtk:BT9727_4700.
PATRICi18990602. VBIBacThu119411_4999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017355 Genomic DNA. Translation: AAT62561.1 .
RefSeqi YP_039010.1. NC_005957.1.

3D structure databases

ProteinModelPortali Q6HBR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281309.BT9727_4700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT62561 ; AAT62561 ; BT9727_4700 .
GeneIDi 2853657.
KEGGi btk:BT9727_4700.
PATRICi 18990602. VBIBacThu119411_4999.

Phylogenomic databases

eggNOGi COG0509.
HOGENOMi HOG000239392.
KOi K02437.
OMAi ADEYTAF.
OrthoDBi EOG60CWTC.

Enzyme and pathway databases

BioCyci BTHU281309:GJID-4791-MONOMER.

Family and domain databases

HAMAPi MF_00272. GcvH.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR002930. GCV_H.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
[Graphical view ]
PANTHERi PTHR11715. PTHR11715. 1 hit.
Pfami PF01597. GCV_H. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR00527. gcvH. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 97-27.

Entry informationi

Entry nameiGCSH_BACHK
AccessioniPrimary (citable) accession number: Q6HBR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3