Q6HBR6 (GCSH_BACHK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine cleavage system H protein

Alternative name(s):
Octanoyl/lipoyl carrier protein

Gene names

Name:	gcvH
Ordered Locus Names:	BT9727_4700

Organism

Bacillus thuringiensis subsp. konkukian (strain 97-27) [Complete proteome] [HAMAP]

Taxonomic identifier

281309 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus thuringiensis › Bacillus thuringiensis subsp. konkukian

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein By similarity. HAMAP-Rule MF_00272 Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate By similarity. HAMAP-Rule MF_00272
Cofactor	Binds 1 lipoyl cofactor covalently By similarity.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvH family. Contains 1 lipoyl-binding domain.

Ontologies

Keywords
Domain	Lipoyl
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP protein lipoylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	glycine cleavage complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Glycine cleavage system H protein HAMAP-Rule MF_00272		PRO_0000302350
Amino acid modifications
	Modified residue	63	1	N6-lipoyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6HBR6 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 523CA49E2A520C14	FASTA	127	14,045
	10 20 30 40 50 60 MSIPNNLRYS EEHEWVKTEG NEVVIGITHF AQNELGDIVF VELPEVGATI EADEPFGSVE 70 80 90 100 110 120 SVKTVSELYA PVSGKVVAVN EELSDQPELV NESPYEGAWM VKVELSDASQ VEKLLTAEKY AEMTNQD

References

[1]

"Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. , Jackson P.J., Keim P., Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L., Brettin T.S., Gilna P. J. Bacteriol. 188:3382-3390(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017355 Genomic DNA. Translation: AAT62561.1.
RefSeq	YP_039010.1. NC_005957.1.
3D structure databases
HSSP	HSSP built from PDB template 1HTP based on UniProtKB P16048.
ProteinModelPortal	Q6HBR6.
ModBase	Search...
Protein-protein interaction databases
STRING	281309.BT9727_4700.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT62561; AAT62561; BT9727_4700.
GeneID	2853657.
KEGG	btk:BT9727_4700.
PATRIC	18990602. VBIBacThu119411_4999.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0509.
HOGENOM	HOG000239392.
KO	K02437.
OMA	FRIKASD.
ProtClustDB	PRK01202.
Enzyme and pathway databases
BioCyc	BTHU281309:GJID-4791-MONOMER.
Family and domain databases
HAMAP	MF_00272. GcvH.
InterPro	IPR003016. 2-oxoA_DH_lipoyl-BS. IPR002930. GCV_H. IPR017453. GCV_H_sub. IPR011053. Single_hybrid_motif. [Graphical view]
PANTHER	PTHR11715. PTHR11715. 1 hit.
Pfam	PF01597. GCV_H. 1 hit. [Graphical view]
SUPFAM	SSF51230. Hybrid_motif. 1 hit.
TIGRFAMs	TIGR00527. gcvH. 1 hit.
PROSITE	PS00189. LIPOYL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSH_BACHK

Accession

Primary (citable) accession number: Q6HBR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program