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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

Enzyme and pathway databases

BioCyciBTHU281309:G1G14-4791-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Alternative name(s):
Octanoyl/lipoyl carrier proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:BT9727_4700
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001301 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003023501 – 127Glycine cleavage system H proteinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-lipoyllysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6HBR6
SMRiQ6HBR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 104Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

HOGENOMiHOG000239392
KOiK02437
OMAiIVYVEVE

Family and domain databases

CDDicd06848 GCS_H, 1 hit
HAMAPiMF_00272 GcvH, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR000089 Biotin_lipoyl
IPR002930 GCV_H
IPR033753 GCV_H/Fam206
IPR017453 GCV_H_sub
IPR011053 Single_hybrid_motif
PANTHERiPTHR11715 PTHR11715, 1 hit
PfamiView protein in Pfam
PF01597 GCV_H, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00527 gcvH, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

Q6HBR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPNNLRYS EEHEWVKTEG NEVVIGITHF AQNELGDIVF VELPEVGATI
60 70 80 90 100
EADEPFGSVE SVKTVSELYA PVSGKVVAVN EELSDQPELV NESPYEGAWM
110 120
VKVELSDASQ VEKLLTAEKY AEMTNQD
Length:127
Mass (Da):14,045
Last modified:July 19, 2004 - v1
Checksum:i523CA49E2A520C14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA Translation: AAT62561.1
RefSeqiWP_000026899.1, NC_005957.1
YP_039010.1, NC_005957.1

Genome annotation databases

EnsemblBacteriaiAAT62561; AAT62561; BT9727_4700
GeneIDi2853657
KEGGibtk:BT9727_4700
PATRICifig|281309.8.peg.4999

Similar proteinsi

Entry informationi

Entry nameiGCSH_BACHK
AccessioniPrimary (citable) accession number: Q6HBR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome