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Q6HBR6

- GCSH_BACHK

UniProt

Q6HBR6 - GCSH_BACHK

Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation
    Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.UniRule annotation

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
    2. protein lipoylation Source: UniProtKB-HAMAP

    Enzyme and pathway databases

    BioCyciBTHU281309:GJID-4791-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine cleavage system H proteinUniRule annotation
    Alternative name(s):
    Octanoyl/lipoyl carrier proteinUniRule annotation
    Gene namesi
    Name:gcvHUniRule annotation
    Ordered Locus Names:BT9727_4700
    OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
    Taxonomic identifieri281309 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000001301: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. glycine cleavage complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Glycine cleavage system H proteinPRO_0000302350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631N6-lipoyllysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi281309.BT9727_4700.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6HBR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvH family.UniRule annotation
    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    Lipoyl

    Phylogenomic databases

    eggNOGiCOG0509.
    HOGENOMiHOG000239392.
    KOiK02437.
    OMAiADEYTAF.
    OrthoDBiEOG60CWTC.

    Family and domain databases

    HAMAPiMF_00272. GcvH.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR002930. GCV_H.
    IPR017453. GCV_H_sub.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PANTHERiPTHR11715. PTHR11715. 1 hit.
    PfamiPF01597. GCV_H. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR00527. gcvH. 1 hit.
    PROSITEiPS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6HBR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIPNNLRYS EEHEWVKTEG NEVVIGITHF AQNELGDIVF VELPEVGATI    50
    EADEPFGSVE SVKTVSELYA PVSGKVVAVN EELSDQPELV NESPYEGAWM 100
    VKVELSDASQ VEKLLTAEKY AEMTNQD 127
    Length:127
    Mass (Da):14,045
    Last modified:July 19, 2004 - v1
    Checksum:i523CA49E2A520C14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017355 Genomic DNA. Translation: AAT62561.1.
    RefSeqiYP_039010.1. NC_005957.1.

    Genome annotation databases

    EnsemblBacteriaiAAT62561; AAT62561; BT9727_4700.
    GeneIDi2853657.
    KEGGibtk:BT9727_4700.
    PATRICi18990602. VBIBacThu119411_4999.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017355 Genomic DNA. Translation: AAT62561.1 .
    RefSeqi YP_039010.1. NC_005957.1.

    3D structure databases

    ProteinModelPortali Q6HBR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281309.BT9727_4700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT62561 ; AAT62561 ; BT9727_4700 .
    GeneIDi 2853657.
    KEGGi btk:BT9727_4700.
    PATRICi 18990602. VBIBacThu119411_4999.

    Phylogenomic databases

    eggNOGi COG0509.
    HOGENOMi HOG000239392.
    KOi K02437.
    OMAi ADEYTAF.
    OrthoDBi EOG60CWTC.

    Enzyme and pathway databases

    BioCyci BTHU281309:GJID-4791-MONOMER.

    Family and domain databases

    HAMAPi MF_00272. GcvH.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR002930. GCV_H.
    IPR017453. GCV_H_sub.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    PANTHERi PTHR11715. PTHR11715. 1 hit.
    Pfami PF01597. GCV_H. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR00527. gcvH. 1 hit.
    PROSITEi PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 97-27.

    Entry informationi

    Entry nameiGCSH_BACHK
    AccessioniPrimary (citable) accession number: Q6HBR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3