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Protein

L-lactate dehydrogenase 3

Gene

ldh3

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 2 (ldh2), L-lactate dehydrogenase 3 (ldh3), L-lactate dehydrogenase 1 (ldh1)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91SubstrateUniRule annotation1
Binding sitei123NAD or substrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptor1
Binding sitei233SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 42NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 3UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 3UniRule annotation
Gene namesi
Name:ldh3UniRule annotation
Ordered Locus Names:BT9727_4708
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001301 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375431 – 316L-lactate dehydrogenase 3Add BLAST316

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6HBQ8.
SMRiQ6HBQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793.
KOiK00016.
OMAiSESCHGW.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6HBQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRHTRKIAI IGTGLVGSSC AYSIVNQGIC EELLLIDINH ERAVGEAMDL
60 70 80 90 100
SHCINFTNTR TKVYAGSYED CKDMDIVIIT AGPAPKPGQS RLDTLGASAK
110 120 130 140 150
IMESVVGGVM ESGFDGIFLL ASNPVDIITY QVWKLSGLPR NRVIGTGTSL
160 170 180 190 200
DSSRLRTILS EMLHVDPRSI HGYSLGEHGD SQMVAWSHVT VGGKPILQIL
210 220 230 240 250
EEQKERFGEI DLDEIVEKTA KAGWEIYKRK GTTYYGIGNS LAYIANSIFN
260 270 280 290 300
DDHRVIAVSA ILDGEYGEYD ICTGVPAIIT RDGIREIVEL NLTEDEESRF
310
AKSNDILRDY MKTIGY
Length:316
Mass (Da):34,798
Last modified:May 30, 2006 - v2
Checksum:iCE4B64686E72E1DF
GO

Sequence cautioni

The sequence AAT63957 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT63957.1. Different initiation.
RefSeqiYP_039018.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT63957; AAT63957; BT9727_4708.
GeneIDi2853614.
KEGGibtk:BT9727_4708.
PATRICifig|281309.8.peg.5009.

Similar proteinsi

Entry informationi

Entry nameiLDH3_BACHK
AccessioniPrimary (citable) accession number: Q6HBQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 22, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families