Q6HBI9 (MURB2_BACHK) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 55.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase 2 EC=1.1.1.158 Alternative name(s): UDP-N-acetylmuramate dehydrogenase 2 | ||||
| Gene names |
| ||||
| Organism | Bacillus thuringiensis subsp. konkukian (strain 97-27) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 281309 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 305 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Cell wall formation By similarity. HAMAP MF_00037 |
| Catalytic activity | UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037 |
| Cofactor | FAD By similarity. HAMAP MF_00037 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00037. |
| Sequence similarities | Belongs to the MurB family. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cytoplasm |
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organizationInferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | UDP-N-acetylmuramate dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 305 | 305 | UDP-N-acetylenolpyruvoylglucosamine reductase 2 HAMAP MF_00037 | PRO_0000224661 | |||||
Regions | |||||||||
| Domain | 33 – 197 | 165 | FAD-binding PCMH-type | ||||||
Sites | |||||||||
| Active site | 176 | 1 | By similarity | ||||||
| Active site | 226 | 1 | Proton donor By similarity | ||||||
| Active site | 296 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis." Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A., Hill K.K., Hitchcock P. Gilna P.J. Bacteriol. 188:3382-3390(2006) [PubMed: 16621833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 97-27. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017355 Genomic DNA. Translation: AAT63301.1. |
| RefSeq | YP_039087.1. NC_005957.1. |
3D structure databases | |
| ProteinModelPortal | Q6HBI9. |
| SMR | Q6HBI9. Positions 4-302. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000072059; EBBACP00000070145; EBBACG00000072050. |
| GeneID | 2853612. |
| GenomeReviews | Gene locus BT9727_4778 in contig AE017355_GR. |
| KEGG | btk:BT9727_4778. |
| NMPDR | fig|281309.1.peg.4727. |
| PATRIC | 18990772. VBIBacThu119411_5084. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000001391. |
| HOGENOM | HBG686573. |
| OMA | SKKHAGF. |
| ProtClustDB | PRK12436. |
Enzyme and pathway databases | |
| BioCyc | BTHU281309:BT9727_4778-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00037. MurB. [Tree] |
| InterPro | IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N. [Graphical view] |
| Gene3D | G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.90.78.10. MurB_C. 1 hit. |
| KO | K00075. |
| PANTHER | PTHR21071. MurB. 1 hit. |
| Pfam | PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit. [Graphical view] |
| SUPFAM | SSF56176. FAD-binding_2. 1 hit. SSF56194. MurB_C. 1 hit. |
| TIGRFAMs | TIGR00179. MurB. 1 hit. |
| PROSITE | PS51387. FAD_PCMH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MURB2_BACHK | ||||||||
| Accession | Primary (citable) accession number: Q6HBI9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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