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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi819ZincUniRule annotation1
Metal bindingi821ZincUniRule annotation1
Metal bindingi830ZincUniRule annotation1
Metal bindingi831ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:BT9727_4868
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001301 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003183221 – 835Protein translocase subunit SecA 1Add BLAST835

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6HB99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218169.
KOiK03070.
OMAiIATERHE.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6HB99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGILKKVFD VNQRQIKRMQ KTVEQIDALE SSIKPLTDEQ LKGKTLEFKE
60 70 80 90 100
RLTKGETVDD LLPEAFAVVR EAATRVLGMR PYGVQLMGGI ALHEGNISEM
110 120 130 140 150
KTGEGKTLTS TLPVYLNALT GKGVHVVTVN EYLAQRDANE MGQLHEFLGL
160 170 180 190 200
TVGINLNSMS REEKQEAYAA DITYSTNNEL GFDYLRDNMV LYKEQCVQRP
210 220 230 240 250
LHFAIIDEVD SILVDEARTP LIISGQAQKS TELYMFANAF VRTLENEKDY
260 270 280 290 300
SFDVKTKNVM LTEDGITKAE KAFHIENLFD LKHVALLHHI NQALRAHVVM
310 320 330 340 350
HRDTDYVVQE GEIVIVDQFT GRLMKGRRYS EGLHQAIEAK EGVEIQNESM
360 370 380 390 400
TLATITFQNY FRMYEKLSGM TGTAKTEEEE FRNIYNMNVI VIPTNKPIIR
410 420 430 440 450
DDRADLIFKS MEGKFNAVVE DIVNRHKQGQ PVLVGTVAIE TSELISKMLT
460 470 480 490 500
RKGVRHNILN AKNHAREADI IAEAGMKGAV TIATNMAGRG TDIKLGDDIK
510 520 530 540 550
NIGLAVIGTE RHESRRIDNQ LRGRAGRQGD PGVTQFYLSM EDELMRRFGS
560 570 580 590 600
DNMKAMMDRL GMDDSQPIES KMVSRAVESA QKRVEGNNYD ARKQLLQYDD
610 620 630 640 650
VLRQQREVIY KQRQEVMESE NLRGIIEGMM KSTVERAVAL HTQEEIEEDW
660 670 680 690 700
NIKGLVDYLN TNLLQEGDVK EEELRRLAPE EMSEPIIAKL IERYNDKEKL
710 720 730 740 750
MPEEQMREFE KVVVFRVVDT KWTEHIDAMD HLREGIHLRA YGQIDPLREY
760 770 780 790 800
QMEGFAMFES MIASIEEEIS RYIMKAEIEQ NLERQEVVQG EAVHPSSDGE
810 820 830
EAKKKPVVKG DQVGRNDLCK CGSGKKYKNC CGIGK
Length:835
Mass (Da):95,076
Last modified:July 19, 2004 - v1
Checksum:i65F7D777E919BCF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT63345.1.
RefSeqiWP_000579368.1. NC_005957.1.
YP_039177.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT63345; AAT63345; BT9727_4868.
GeneIDi2856676.
KEGGibtk:BT9727_4868.
PATRICi18990956. VBIBacThu119411_5175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA. Translation: AAT63345.1.
RefSeqiWP_000579368.1. NC_005957.1.
YP_039177.1. NC_005957.1.

3D structure databases

ProteinModelPortaliQ6HB99.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT63345; AAT63345; BT9727_4868.
GeneIDi2856676.
KEGGibtk:BT9727_4868.
PATRICi18990956. VBIBacThu119411_5175.

Phylogenomic databases

HOGENOMiHOG000218169.
KOiK03070.
OMAiIATERHE.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA1_BACHK
AccessioniPrimary (citable) accession number: Q6HB99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.