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Q6HAV3

- KITH_BACHK

UniProt

Q6HAV3 - KITH_BACHK

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Protein
Thymidine kinase
Gene
tdk, BT9727_5014
Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor Reviewed prediction
Metal bindingi145 – 1451Zinc By similarity
Metal bindingi148 – 1481Zinc By similarity
Metal bindingi183 – 1831Zinc By similarity
Metal bindingi186 – 1861Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarity
Nucleotide bindingi88 – 914ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBTHU281309:GJID-5105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:BT9727_5014
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001301: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Thymidine kinaseUniRule annotation
PRO_0000174960Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi281309.BT9727_5014.

Structurei

3D structure databases

ProteinModelPortaliQ6HAV3.
SMRiQ6HAV3. Positions 1-190.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6HAV3-1 [UniParc]FASTAAdd to Basket

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MYLINQNGWI EVICGSMFSG KSEELIRRVR RTQFAKQHAI VFKPCIDNRY    50
SEEDVVSHNG LKVKAVPVSA SKDIFEHITE EMDVIAIDEV QFFDGDIVEV 100
VQVLANRGYR VIVAGLDQDF RGLPFGQVPQ LMAIAEHVTK LQAVCSACGS 150
PASRTQRLID GEPAAFDDPI ILVGASESYE PRCRHCHAVP TNKDK 195
Length:195
Mass (Da):21,716
Last modified:July 19, 2004 - v1
Checksum:i9A421C56F23B5D99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017355 Genomic DNA. Translation: AAT62617.1.
RefSeqiYP_039323.1. NC_005957.1.

Genome annotation databases

EnsemblBacteriaiAAT62617; AAT62617; BT9727_5014.
GeneIDi2858656.
KEGGibtk:BT9727_5014.
PATRICi18991270. VBIBacThu119411_5332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017355 Genomic DNA. Translation: AAT62617.1 .
RefSeqi YP_039323.1. NC_005957.1.

3D structure databases

ProteinModelPortali Q6HAV3.
SMRi Q6HAV3. Positions 1-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281309.BT9727_5014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT62617 ; AAT62617 ; BT9727_5014 .
GeneIDi 2858656.
KEGGi btk:BT9727_5014.
PATRICi 18991270. VBIBacThu119411_5332.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci BTHU281309:GJID-5105-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 97-27.

Entry informationi

Entry nameiKITH_BACHK
AccessioniPrimary (citable) accession number: Q6HAV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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