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Q6HA10

- GDF6_RAT

UniProt

Q6HA10 - GDF6_RAT

Protein

Growth/differentiation factor 6

Gene

Gdf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A By similarity.By similarity

    GO - Biological processi

    1. activin receptor signaling pathway Source: Ensembl
    2. apoptotic process Source: UniProtKB
    3. BMP signaling pathway Source: Ensembl
    4. growth Source: InterPro
    5. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    6. positive regulation of neuron differentiation Source: Ensembl
    7. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    8. positive regulation of transcription, DNA-templated Source: Ensembl
    9. retinal cell apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 6
    Short name:
    GDF-6
    Alternative name(s):
    Bone morphogenetic protein 13
    Short name:
    BMP-13
    Growth/differentiation factor 16
    Gene namesi
    Name:Gdf6
    Synonyms:Bmp13, Gdf16
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi620104. Gdf6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 332310Sequence AnalysisPRO_0000342208Add
    BLAST
    Chaini333 – 452120Growth/differentiation factor 6PRO_0000042254Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi351 ↔ 417By similarity
    Disulfide bondi380 ↔ 449By similarity
    Disulfide bondi384 ↔ 451By similarity
    Disulfide bondi416 – 416InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6HA10.
    PRIDEiQ6HA10.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6HA10.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010266.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6HA10.
    SMRiQ6HA10. Positions 348-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 337Poly-Ser
    Compositional biasi328 – 3325Poly-Arg

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG317866.
    GeneTreeiENSGT00730000110209.
    HOGENOMiHOG000231514.
    HOVERGENiHBG107938.
    InParanoidiQ6HA10.
    KOiK04664.
    OMAiFTRSQRK.
    OrthoDBiEOG7WMCK0.
    PhylomeDBiQ6HA10.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6HA10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTPRVLLWA IFLISFLWDL PGFQQASISS SSSTELDSTK DVENRKGGKM    50
    QRTPQESAEG RTPKEHRPRP NELRRRLPGQ SLGQEPPGRG PRVVPHEYML 100
    SIYRTYSIAE KLGINASFFQ SSKSANTITS FVDRGLDDLS HTPLRRQKYL 150
    FDVSTLSDKE ELVGAELRLY RQAPPTPWGP QTRPLHLQLF PCLSPLLLDS 200
    RTLDPQGPTE AGWEVFDVWQ VLRPQPWKQL CLELRAVWGE LDARDSGARP 250
    RGPQQSPPLD LRSLGFGRRV RPPQERALLV VFTRSQRKNL FTEMHEQLGS 300
    AEAAGAEGSW PAPSGAPDAG SWLPSPGRRR RRTALSSRHG KRHGKKSRLR 350
    CSRKPLHVNF KELGWDDWII APLEYEAYHC EGVCDFPLRS HLEPTNHAII 400
    QTLMNSMDPG STPPSCCVPT KLTPISILYI DAGNNVVYKQ YEDMVVESCG 450
    CR 452
    Length:452
    Mass (Da):51,013
    Last modified:July 19, 2004 - v1
    Checksum:iDF756875E4C1B52A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ537426 mRNA. Translation: CAD60936.2.
    AB087405 mRNA. Translation: BAC02714.1.
    RefSeqiNP_001013056.1. NM_001013038.1.
    UniGeneiRn.49815.

    Genome annotation databases

    EnsembliENSRNOT00000010266; ENSRNOP00000010266; ENSRNOG00000007810.
    GeneIDi252834.
    KEGGirno:252834.
    UCSCiRGD:620104. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ537426 mRNA. Translation: CAD60936.2 .
    AB087405 mRNA. Translation: BAC02714.1 .
    RefSeqi NP_001013056.1. NM_001013038.1.
    UniGenei Rn.49815.

    3D structure databases

    ProteinModelPortali Q6HA10.
    SMRi Q6HA10. Positions 348-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010266.

    Proteomic databases

    PaxDbi Q6HA10.
    PRIDEi Q6HA10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010266 ; ENSRNOP00000010266 ; ENSRNOG00000007810 .
    GeneIDi 252834.
    KEGGi rno:252834.
    UCSCi RGD:620104. rat.

    Organism-specific databases

    CTDi 392255.
    RGDi 620104. Gdf6.

    Phylogenomic databases

    eggNOGi NOG317866.
    GeneTreei ENSGT00730000110209.
    HOGENOMi HOG000231514.
    HOVERGENi HBG107938.
    InParanoidi Q6HA10.
    KOi K04664.
    OMAi FTRSQRK.
    OrthoDBi EOG7WMCK0.
    PhylomeDBi Q6HA10.
    TreeFami TF316134.

    Miscellaneous databases

    NextBioi 623902.
    PROi Q6HA10.

    Gene expression databases

    Genevestigatori Q6HA10.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human Gdf16 and associated analysis."
      Guo J.H.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Molecular cloning of PCR amplified BMP-related genes (GDF-5, 6 and 7) from rat tooth cells using modified pBluescript SK+ Vector."
      Oida S., Morotome Y., Nakamura T., Terashima T.
      J. Hard Tissue Biol. 6:16-20(1997)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 372-438.
      Tissue: Tooth.

    Entry informationi

    Entry nameiGDF6_RAT
    AccessioniPrimary (citable) accession number: Q6HA10
    Secondary accession number(s): Q8K4X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3