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Protein

Growth/differentiation factor 6

Gene

Gdf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 6
Short name:
GDF-6
Alternative name(s):
Bone morphogenetic protein 13
Short name:
BMP-13
Growth/differentiation factor 16
Gene namesi
Name:Gdf6
Synonyms:Bmp13, Gdf16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620104. Gdf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 332310Sequence AnalysisPRO_0000342208Add
BLAST
Chaini333 – 452120Growth/differentiation factor 6PRO_0000042254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi351 ↔ 417By similarity
Disulfide bondi380 ↔ 449By similarity
Disulfide bondi384 ↔ 451By similarity
Disulfide bondi416 – 416InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6HA10.
PRIDEiQ6HA10.

Expressioni

Gene expression databases

GenevisibleiQ6HA10. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010266.

Structurei

3D structure databases

ProteinModelPortaliQ6HA10.
SMRiQ6HA10. Positions 348-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 337Poly-Ser
Compositional biasi328 – 3325Poly-Arg

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiQ6HA10.
KOiK04664.
OMAiFTRSQRK.
OrthoDBiEOG7WMCK0.
PhylomeDBiQ6HA10.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6HA10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPRVLLWA IFLISFLWDL PGFQQASISS SSSTELDSTK DVENRKGGKM
60 70 80 90 100
QRTPQESAEG RTPKEHRPRP NELRRRLPGQ SLGQEPPGRG PRVVPHEYML
110 120 130 140 150
SIYRTYSIAE KLGINASFFQ SSKSANTITS FVDRGLDDLS HTPLRRQKYL
160 170 180 190 200
FDVSTLSDKE ELVGAELRLY RQAPPTPWGP QTRPLHLQLF PCLSPLLLDS
210 220 230 240 250
RTLDPQGPTE AGWEVFDVWQ VLRPQPWKQL CLELRAVWGE LDARDSGARP
260 270 280 290 300
RGPQQSPPLD LRSLGFGRRV RPPQERALLV VFTRSQRKNL FTEMHEQLGS
310 320 330 340 350
AEAAGAEGSW PAPSGAPDAG SWLPSPGRRR RRTALSSRHG KRHGKKSRLR
360 370 380 390 400
CSRKPLHVNF KELGWDDWII APLEYEAYHC EGVCDFPLRS HLEPTNHAII
410 420 430 440 450
QTLMNSMDPG STPPSCCVPT KLTPISILYI DAGNNVVYKQ YEDMVVESCG

CR
Length:452
Mass (Da):51,013
Last modified:July 19, 2004 - v1
Checksum:iDF756875E4C1B52A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ537426 mRNA. Translation: CAD60936.2.
AB087405 mRNA. Translation: BAC02714.1.
RefSeqiNP_001013056.1. NM_001013038.1.
UniGeneiRn.49815.

Genome annotation databases

EnsembliENSRNOT00000010266; ENSRNOP00000010266; ENSRNOG00000007810.
GeneIDi252834.
KEGGirno:252834.
UCSCiRGD:620104. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ537426 mRNA. Translation: CAD60936.2.
AB087405 mRNA. Translation: BAC02714.1.
RefSeqiNP_001013056.1. NM_001013038.1.
UniGeneiRn.49815.

3D structure databases

ProteinModelPortaliQ6HA10.
SMRiQ6HA10. Positions 348-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010266.

Proteomic databases

PaxDbiQ6HA10.
PRIDEiQ6HA10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010266; ENSRNOP00000010266; ENSRNOG00000007810.
GeneIDi252834.
KEGGirno:252834.
UCSCiRGD:620104. rat.

Organism-specific databases

CTDi392255.
RGDi620104. Gdf6.

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiQ6HA10.
KOiK04664.
OMAiFTRSQRK.
OrthoDBiEOG7WMCK0.
PhylomeDBiQ6HA10.
TreeFamiTF316134.

Miscellaneous databases

NextBioi623902.
PROiQ6HA10.

Gene expression databases

GenevisibleiQ6HA10. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of human Gdf16 and associated analysis."
    Guo J.H.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Molecular cloning of PCR amplified BMP-related genes (GDF-5, 6 and 7) from rat tooth cells using modified pBluescript SK+ Vector."
    Oida S., Morotome Y., Nakamura T., Terashima T.
    J. Hard Tissue Biol. 6:16-20(1997)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 372-438.
    Tissue: Tooth.

Entry informationi

Entry nameiGDF6_RAT
AccessioniPrimary (citable) accession number: Q6HA10
Secondary accession number(s): Q8K4X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 19, 2004
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.