Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth/differentiation factor 6

Gene

Gdf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 6
Short name:
GDF-6
Alternative name(s):
Bone morphogenetic protein 13
Short name:
BMP-13
Growth/differentiation factor 16
Gene namesi
Name:Gdf6
Synonyms:Bmp13, Gdf16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620104. Gdf6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000034220823 – 332Sequence analysisAdd BLAST310
ChainiPRO_0000042254333 – 452Growth/differentiation factor 6Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi351 ↔ 417By similarity
Disulfide bondi380 ↔ 449By similarity
Disulfide bondi384 ↔ 451By similarity
Disulfide bondi416InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6HA10.
PRIDEiQ6HA10.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007810.
GenevisibleiQ6HA10. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010266.

Structurei

3D structure databases

ProteinModelPortaliQ6HA10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 33Poly-Ser7
Compositional biasi328 – 332Poly-Arg5

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiQ6HA10.
KOiK20012.
OMAiFTRSQRK.
OrthoDBiEOG091G09KP.
PhylomeDBiQ6HA10.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6HA10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPRVLLWA IFLISFLWDL PGFQQASISS SSSTELDSTK DVENRKGGKM
60 70 80 90 100
QRTPQESAEG RTPKEHRPRP NELRRRLPGQ SLGQEPPGRG PRVVPHEYML
110 120 130 140 150
SIYRTYSIAE KLGINASFFQ SSKSANTITS FVDRGLDDLS HTPLRRQKYL
160 170 180 190 200
FDVSTLSDKE ELVGAELRLY RQAPPTPWGP QTRPLHLQLF PCLSPLLLDS
210 220 230 240 250
RTLDPQGPTE AGWEVFDVWQ VLRPQPWKQL CLELRAVWGE LDARDSGARP
260 270 280 290 300
RGPQQSPPLD LRSLGFGRRV RPPQERALLV VFTRSQRKNL FTEMHEQLGS
310 320 330 340 350
AEAAGAEGSW PAPSGAPDAG SWLPSPGRRR RRTALSSRHG KRHGKKSRLR
360 370 380 390 400
CSRKPLHVNF KELGWDDWII APLEYEAYHC EGVCDFPLRS HLEPTNHAII
410 420 430 440 450
QTLMNSMDPG STPPSCCVPT KLTPISILYI DAGNNVVYKQ YEDMVVESCG

CR
Length:452
Mass (Da):51,013
Last modified:July 19, 2004 - v1
Checksum:iDF756875E4C1B52A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ537426 mRNA. Translation: CAD60936.2.
AB087405 mRNA. Translation: BAC02714.1.
RefSeqiNP_001013056.1. NM_001013038.1.
UniGeneiRn.49815.

Genome annotation databases

EnsembliENSRNOT00000010266; ENSRNOP00000010266; ENSRNOG00000007810.
GeneIDi252834.
KEGGirno:252834.
UCSCiRGD:620104. rat.

Similar proteinsi

Entry informationi

Entry nameiGDF6_RAT
AccessioniPrimary (citable) accession number: Q6HA10
Secondary accession number(s): Q8K4X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families