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Q6HA10 (GDF6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Growth/differentiation factor 6
Short name=GDF-6
Alternative name(s):
Growth/differentiation factor 16
Gene names
Name:Gdf6
Synonyms:Gdf16
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the TGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 327305 Potential
PRO_0000342208
Chain333 – 452120Growth/differentiation factor 6
PRO_0000042254

Regions

Compositional bias27 – 337Poly-Ser
Compositional bias328 – 3325Poly-Arg

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Disulfide bond351 ↔ 417 By similarity
Disulfide bond380 ↔ 449 By similarity
Disulfide bond384 ↔ 451 By similarity
Disulfide bond416Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6HA10 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: DF756875E4C1B52A

FASTA45251,013
        10         20         30         40         50         60 
MDTPRVLLWA IFLISFLWDL PGFQQASISS SSSTELDSTK DVENRKGGKM QRTPQESAEG 

        70         80         90        100        110        120 
RTPKEHRPRP NELRRRLPGQ SLGQEPPGRG PRVVPHEYML SIYRTYSIAE KLGINASFFQ 

       130        140        150        160        170        180 
SSKSANTITS FVDRGLDDLS HTPLRRQKYL FDVSTLSDKE ELVGAELRLY RQAPPTPWGP 

       190        200        210        220        230        240 
QTRPLHLQLF PCLSPLLLDS RTLDPQGPTE AGWEVFDVWQ VLRPQPWKQL CLELRAVWGE 

       250        260        270        280        290        300 
LDARDSGARP RGPQQSPPLD LRSLGFGRRV RPPQERALLV VFTRSQRKNL FTEMHEQLGS 

       310        320        330        340        350        360 
AEAAGAEGSW PAPSGAPDAG SWLPSPGRRR RRTALSSRHG KRHGKKSRLR CSRKPLHVNF 

       370        380        390        400        410        420 
KELGWDDWII APLEYEAYHC EGVCDFPLRS HLEPTNHAII QTLMNSMDPG STPPSCCVPT 

       430        440        450 
KLTPISILYI DAGNNVVYKQ YEDMVVESCG CR

« Hide

References

[1]"Cloning of human Gdf16 and associated analysis."
Guo J.H.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Molecular cloning of PCR amplified BMP-related genes (GDF-5, 6 and 7) from rat tooth cells using modified pBluescript SK+ Vector."
Oida S., Morotome Y., Nakamura T., Terashima T.
J. Hard Tissue Biol. 6:16-20(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 372-438.
Tissue: Tooth.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ537426 mRNA. Translation: CAD60936.2.
AB087405 mRNA. Translation: BAC02714.1.
IPIIPI00454588.
RefSeqNP_001013056.1. NM_001013038.1.
UniGeneRn.49815.

3D structure databases

ProteinModelPortalQ6HA10.
SMRQ6HA10. Positions 348-452.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010266.

Proteomic databases

PaxDbQ6HA10.
PRIDEQ6HA10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010266; ENSRNOP00000010266; ENSRNOG00000007810.
GeneID252834.
KEGGrno:252834.
UCSCRGD:620104. rat.

Organism-specific databases

CTD392255.
RGD620104. Gdf6.

Phylogenomic databases

eggNOGNOG317866.
GeneTreeENSGT00690000101685.
HOGENOMHOG000231514.
HOVERGENHBG107938.
InParanoidQ6HA10.
KOK04664.
OMAFTRSQRK.
OrthoDBEOG4S4PG9.

Gene expression databases

GenevestigatorQ6HA10.
GermOnlineENSRNOG00000007810. Rattus norvegicus.

Family and domain databases

InterProIPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623902.

Entry information

Entry nameGDF6_RAT
AccessionPrimary (citable) accession number: Q6HA10
Secondary accession number(s): Q8K4X4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 19, 2004
Last modified: April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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