Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isthmin-2

Gene

ISM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Isthmin-2
Alternative name(s):
Thrombospondin and AMOP domain-containing isthmin-like protein 1
Thrombospondin type-1 domain-containing protein 3
Gene namesi
Name:ISM2
Synonyms:TAIL1, THSD3
ORF Names:PSEC0137
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23176. ISM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721097.

Polymorphism and mutation databases

BioMutaiISM2.
DMDMi74724655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 571545Isthmin-2PRO_5000072090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi338 ↔ 365PROSITE-ProRule annotation
Disulfide bondi342 ↔ 370PROSITE-ProRule annotation
Disulfide bondi353 ↔ 357PROSITE-ProRule annotation
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6H9L7.
PeptideAtlasiQ6H9L7.
PRIDEiQ6H9L7.

PTM databases

iPTMnetiQ6H9L7.
PhosphoSiteiQ6H9L7.

Expressioni

Tissue specificityi

Expressed at high levels in the placenta and at moderate levels in the pancreas, kidney, heart, liver, lung, brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ6H9L7.
ExpressionAtlasiQ6H9L7. baseline and differential.
GenevisibleiQ6H9L7. HS.

Organism-specific databases

HPAiHPA039314.
HPA039742.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341490.

Structurei

3D structure databases

ProteinModelPortaliQ6H9L7.
SMRiQ6H9L7. Positions 330-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini327 – 37145TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini396 – 559164AMOPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 624Poly-Glu
Compositional biasi140 – 1434Poly-Glu

Sequence similaritiesi

Belongs to the isthmin family.Curated
Contains 1 AMOP domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE9A. Eukaryota.
ENOG410XT8R. LUCA.
GeneTreeiENSGT00390000018792.
HOVERGENiHBG108010.
InParanoidiQ6H9L7.
OMAiRTRPCGY.
OrthoDBiEOG776SPR.
PhylomeDBiQ6H9L7.
TreeFamiTF331333.

Family and domain databases

InterProiIPR005533. AMOP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF03782. AMOP. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00723. AMOP. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50856. AMOP. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6H9L7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALRDRAGL LLCVLLLAAL LEAALGLPVK KPRLRGPRPG SLTRLAEVSA
60 70 80 90 100
SPDPRPLKEE EEAPLLPRTH LQAEPHQHGC WTVTEPAAMT PGNATPPRTP
110 120 130 140 150
EVTPLRLELQ KLPGLANTTL STPNPDTQAS ASPDPRPLRE EEEARLLPRT
160 170 180 190 200
HLQAELHQHG CWTVTEPAAL TPGNATPPRT QEVTPLLLEL QKLPELVHAT
210 220 230 240 250
LSTPNPDNQV TIKVVEDPQA EVSIDLLAEP SNPPPQDTLS WLPALWSFLW
260 270 280 290 300
GDYKGEEKDR APGEKGEEKE EDEDYPSEDI EGEDQEDKEE DEEEQALWFN
310 320 330 340 350
GTTDNWDQGW LAPGDWVFKD SVSYDYEPQK EWSPWSPCSG NCSTGKQQRT
360 370 380 390 400
RPCGYGCTAT ETRTCDLPSC PGTEDKDTLG LPSEEWKLLA RNATDMHDQD
410 420 430 440 450
VDSCEKWLNC KSDFLIKYLS QMLRDLPSCP CAYPLEAMDS PVSLQDEHQG
460 470 480 490 500
RSFRWRDASG PRERLDIYQP TARFCLRSML SGESSTLAAQ HCCYDEDSRL
510 520 530 540 550
LTRGKGAGMP NLISTDFSPK LHFKFDTTPW ILCKGDWSRL HAVLPPNNGR
560 570
ACTDNPLEEE YLAQLQEAKE Y
Length:571
Mass (Da):63,906
Last modified:July 19, 2004 - v1
Checksum:iD83329D10F300C7C
GO
Isoform 2 (identifier: Q6H9L7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-292: VTIKVVEDPQ...EDQEDKEEDE → TMSLRRSGVP...IKMWTAVRSG
     293-571: Missing.

Show »
Length:292
Mass (Da):31,333
Checksum:i3F854F5D1BA0E8D9
GO
Isoform 3 (identifier: Q6H9L7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-128: Missing.

Show »
Length:490
Mass (Da):55,148
Checksum:i49BEA9B6C3EAC8B7
GO
Isoform 4 (identifier: Q6H9L7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-76: VSASPDPRPLKEEEEAPLLPRTHLQAEPH → PPFQVRASSERSPAGARNLALCGVAGQGR
     77-571: Missing.

Show »
Length:76
Mass (Da):7,996
Checksum:iE07DAEB3A9AC94B8
GO
Isoform 5 (identifier: Q6H9L7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-209: Missing.

Show »
Length:490
Mass (Da):54,996
Checksum:i706CC7F7BD92252E
GO

Sequence cautioni

The sequence AAD09622.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAD62605.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD66577.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW81296.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171N → S in BAC11626 (PubMed:16303743).Curated
Sequence conflicti247 – 2471S → P in BAC11626 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941A → T.4 Publications
Corresponds to variant rs3742728 [ dbSNP | Ensembl ].
VAR_035365
Natural varianti133 – 1331P → A.1 Publication
Corresponds to variant rs11850175 [ dbSNP | Ensembl ].
VAR_035366

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 12881Missing in isoform 3. 1 PublicationVSP_028612Add
BLAST
Alternative sequencei48 – 7629VSASP…QAEPH → PPFQVRASSERSPAGARNLA LCGVAGQGR in isoform 4. 1 PublicationVSP_029679Add
BLAST
Alternative sequencei77 – 571495Missing in isoform 4. 1 PublicationVSP_029680Add
BLAST
Alternative sequencei129 – 20981Missing in isoform 5. 1 PublicationVSP_029681Add
BLAST
Alternative sequencei210 – 29283VTIKV…KEEDE → TMSLRRSGVPGLPAVGTAAL ASSRGLGPVAMAALPPRPVP VTCPPVLALRTRTPWASPVR SGSSWPAMLRTCMIKMWTAV RSG in isoform 2. 2 PublicationsVSP_028610Add
BLAST
Alternative sequencei293 – 571279Missing in isoform 2. 2 PublicationsVSP_028611Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583024 mRNA. Translation: CAE47313.1.
BX248277 mRNA. Translation: CAD62605.1. Different initiation.
BX248280 mRNA. Translation: CAD62608.1.
BX248770 mRNA. Translation: CAD66577.1. Different initiation.
AK075445 mRNA. Translation: BAC11626.1.
AK291600 mRNA. Translation: BAF84289.1.
CR749863 mRNA. Translation: CAH18707.2.
AF111168 Genomic DNA. Translation: AAD09622.1. Sequence problems.
CH471061 Genomic DNA. Translation: EAW81296.1. Sequence problems.
BC033140 mRNA. Translation: AAH33140.1.
BC101019 mRNA. Translation: AAI01020.1.
BC101020 mRNA. Translation: AAI01021.1.
BC101021 mRNA. Translation: AAI01022.2.
BC101022 mRNA. Translation: AAI01023.1.
CCDSiCCDS45143.1. [Q6H9L7-2]
CCDS9864.1. [Q6H9L7-1]
RefSeqiNP_872315.2. NM_182509.3. [Q6H9L7-2]
NP_954993.1. NM_199296.2. [Q6H9L7-1]
UniGeneiHs.29742.

Genome annotation databases

EnsembliENST00000216481; ENSP00000216481; ENSG00000100593. [Q6H9L7-4]
ENST00000342219; ENSP00000341490; ENSG00000100593. [Q6H9L7-1]
ENST00000493585; ENSP00000420452; ENSG00000100593. [Q6H9L7-2]
GeneIDi145501.
KEGGihsa:145501.
UCSCiuc001xtz.4. human. [Q6H9L7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583024 mRNA. Translation: CAE47313.1.
BX248277 mRNA. Translation: CAD62605.1. Different initiation.
BX248280 mRNA. Translation: CAD62608.1.
BX248770 mRNA. Translation: CAD66577.1. Different initiation.
AK075445 mRNA. Translation: BAC11626.1.
AK291600 mRNA. Translation: BAF84289.1.
CR749863 mRNA. Translation: CAH18707.2.
AF111168 Genomic DNA. Translation: AAD09622.1. Sequence problems.
CH471061 Genomic DNA. Translation: EAW81296.1. Sequence problems.
BC033140 mRNA. Translation: AAH33140.1.
BC101019 mRNA. Translation: AAI01020.1.
BC101020 mRNA. Translation: AAI01021.1.
BC101021 mRNA. Translation: AAI01022.2.
BC101022 mRNA. Translation: AAI01023.1.
CCDSiCCDS45143.1. [Q6H9L7-2]
CCDS9864.1. [Q6H9L7-1]
RefSeqiNP_872315.2. NM_182509.3. [Q6H9L7-2]
NP_954993.1. NM_199296.2. [Q6H9L7-1]
UniGeneiHs.29742.

3D structure databases

ProteinModelPortaliQ6H9L7.
SMRiQ6H9L7. Positions 330-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341490.

PTM databases

iPTMnetiQ6H9L7.
PhosphoSiteiQ6H9L7.

Polymorphism and mutation databases

BioMutaiISM2.
DMDMi74724655.

Proteomic databases

PaxDbiQ6H9L7.
PeptideAtlasiQ6H9L7.
PRIDEiQ6H9L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216481; ENSP00000216481; ENSG00000100593. [Q6H9L7-4]
ENST00000342219; ENSP00000341490; ENSG00000100593. [Q6H9L7-1]
ENST00000493585; ENSP00000420452; ENSG00000100593. [Q6H9L7-2]
GeneIDi145501.
KEGGihsa:145501.
UCSCiuc001xtz.4. human. [Q6H9L7-1]

Organism-specific databases

CTDi145501.
GeneCardsiISM2.
HGNCiHGNC:23176. ISM2.
HPAiHPA039314.
HPA039742.
MIMi612684. gene.
neXtProtiNX_Q6H9L7.
PharmGKBiPA164721097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE9A. Eukaryota.
ENOG410XT8R. LUCA.
GeneTreeiENSGT00390000018792.
HOVERGENiHBG108010.
InParanoidiQ6H9L7.
OMAiRTRPCGY.
OrthoDBiEOG776SPR.
PhylomeDBiQ6H9L7.
TreeFamiTF331333.

Miscellaneous databases

GenomeRNAii145501.
PROiQ6H9L7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6H9L7.
ExpressionAtlasiQ6H9L7. baseline and differential.
GenevisibleiQ6H9L7. HS.

Family and domain databases

InterProiIPR005533. AMOP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF03782. AMOP. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00723. AMOP. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50856. AMOP. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region."
    Rossi V., Beffagna G., Rampazzo A., Bauce B., Danieli G.A.
    Gene 335:101-108(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY.
    Tissue: Heart.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-461 (ISOFORM 1).
    Tissue: Placenta.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-94.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-94.
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-94.
    Tissue: Cervix.
  6. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-94 AND ALA-133.
    Tissue: Placenta.

Entry informationi

Entry nameiISM2_HUMAN
AccessioniPrimary (citable) accession number: Q6H9L7
Secondary accession number(s): A8K6D5
, O95432, Q495U5, Q68CN3, Q86TQ7, Q86TW3, Q86TW4, Q8N501, Q8NBL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 19, 2004
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.