Q6H8Q1 (ABLM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-binding LIM protein 2
Short name=abLIM-2

Alternative name(s):
Actin-binding LIM protein family member 2

Gene names

Name:	ABLIM2
Synonyms:	KIAA1808

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Ref.1
Subunit structure	Interacts with F-actin and ABRA. Ref.1
Subcellular location	Cytoplasm. Note: In skeletal muscle, sarcomeric or cosarcomeric localization By similarity.
Tissue specificity	Highly expressed in skeletal muscle. Ref.1
Sequence similarities	Contains 1 HP (headpiece) domain. Contains 4 LIM zinc-binding domains.
Sequence caution	The sequence AAH67214.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	actin cytoskeleton Inferred from direct assay Ref.1. Source: MGI cytoplasm Non-traceable author statement. Source: UniProtKB intermediate filament cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	zinc ion binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6H8Q1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6H8Q1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Isoform 3 (identifier: Q6H8Q1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: E → ESPQLLSPTPTE
     390-441: Missing.
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Isoform 4 (identifier: Q6H8Q1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     349-349: E → ESPQLLSPTPTE
     389-422: Missing.
     459-459: K → KQ

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6H8Q1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: K → KQ
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Note: No experimental confirmation available.

Isoform 6 (identifier: Q6H8Q1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: E → ESPQLLSPTPTE
     390-441: Missing.
     459-459: K → KQ
     507-510: FPYS → EWFF
     511-611: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q6H8Q1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     390-441: Missing.

Isoform 8 (identifier: Q6H8Q1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     390-441: Missing.
     459-459: K → KQ
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 611

611

Actin-binding LIM protein 2

PRO_0000075699

Regions

Domain

22 – 81

60

LIM zinc-binding 1

Domain

81 – 141

61

LIM zinc-binding 2

Domain

151 – 210

60

LIM zinc-binding 3

Domain

210 – 270

61

LIM zinc-binding 4

Domain

543 – 611

69

HP

Sites

Metal binding

83

1

Zinc 1

Metal binding

86

1

Zinc 1

Metal binding

103

1

Zinc 1

Metal binding

106

1

Zinc 1

Metal binding

109

1

Zinc 2

Metal binding

112

1

Zinc 2

Metal binding

131

1

Zinc 2

Metal binding

134

1

Zinc 2

Metal binding

212

1

Zinc 3

Metal binding

215

1

Zinc 3

Metal binding

232

1

Zinc 3

Metal binding

235

1

Zinc 3

Metal binding

238

1

Zinc 4

Metal binding

241

1

Zinc 4

Metal binding

260

1

Zinc 4

Metal binding

263

1

Zinc 4

Amino acid modifications

Modified residue

289

1

Phosphoserine By similarity

Modified residue

294

1

Phosphoserine By similarity

Modified residue

296

1

Phosphoserine By similarity

Modified residue

476

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 243

243

Missing in isoform 4.

VSP_012112

Alternative sequence

349

1

E → ESPQLLSPTPTE in isoform 3, isoform 4 and isoform 6.

VSP_012113

Alternative sequence

389 – 422

34

Missing in isoform 4.

VSP_012114

Alternative sequence

390 – 441

52

Missing in isoform 3, isoform 6, isoform 7 and isoform 8.

VSP_012115

Alternative sequence

459

1

K → KQ in isoform 4, isoform 5, isoform 6 and isoform 8.

VSP_012116

Alternative sequence

506 – 545

40

RFPYS…WGMRE → Q in isoform 2, isoform 3, isoform 5 and isoform 8.

VSP_012117

Alternative sequence

507 – 510

4

FPYS → EWFF in isoform 6.

VSP_012118

Alternative sequence

511 – 611

101

Missing in isoform 6.

VSP_012119

Natural variant

227

1

G → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. Ref.9

VAR_062665

Natural variant

274

1

K → M in a pancreatic ductal adenocarcinoma sample; somatic mutation. Ref.9

VAR_062666

Experimental info

Sequence conflict

240

1

R → G in BAC04414. Ref.3

Sequence conflict

312

1

D → G in BAC04414. Ref.3

Secondary structure

1

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611

Helix Strand Turn

Details...

Helix

75 – 77

3

Turn

84 – 86

3

Beta strand

95 – 97

3

Beta strand

100 – 102

3

Turn

104 – 106

3

Beta strand

110 – 112

3

Beta strand

118 – 120

3

Beta strand

122 – 125

4

Beta strand

128 – 131

4

Helix

132 – 135

4

Beta strand

213 – 215

3

Turn

233 – 235

3

Beta strand

239 – 241

3

Beta strand

252 – 254

3

Beta strand

257 – 259

3

Helix

263 – 266

4

Beta strand

268 – 271

4

Helix

551 – 554

4

Helix

556 – 558

3

Turn

559 – 561

3

Beta strand

570 – 572

3

Helix

573 – 576

4

Helix

579 – 586

8

Helix

590 – 595

6

Helix

598 – 607

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 2. Checksum: 225A4E25646B370B	FASTA	611	67,812
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 370 380 390 400 410 420 RTSSPSSTGS VSLGRYTPTS RSPQHYSRPG SESGRSTPSL SVLSDSKPPP STYQQAPRHF 430 440 450 460 470 480 HVPDTGVKDN IYRKPPIYRQ HAARRSDGED GSLDQDNRKK SSWLMLKGDA DTRTNSPDLD 490 500 510 520 530 540 TQSLSHSSGT DRDPLQRMAG DSFHSRFPYS KSDPLPGHGK NGLDQRNANL APCGADPDAS 550 560 570 580 590 600 WGMREYKIYP YDSLIVTNRI RVKLPKDVDR TRLERHLSPE EFQEVFGMSI EEFDRLALWK 610 RNDLKKKALL F
	Isoform 2 [UniParc]. Checksum: F2CF3EEE6B1CCADC	FASTA	572	63,632
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 370 380 390 400 410 420 RTSSPSSTGS VSLGRYTPTS RSPQHYSRPG SESGRSTPSL SVLSDSKPPP STYQQAPRHF 430 440 450 460 470 480 HVPDTGVKDN IYRKPPIYRQ HAARRSDGED GSLDQDNRKK SSWLMLKGDA DTRTNSPDLD 490 500 510 520 530 540 TQSLSHSSGT DRDPLQRMAG DSFHSQYKIY PYDSLIVTNR IRVKLPKDVD RTRLERHLSP 550 560 570 EEFQEVFGMS IEEFDRLALW KRNDLKKKAL LF
	Isoform 3 [UniParc]. Checksum: 1E6B36B85E5176D8	FASTA	531	58,984
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGES PQLLSPTPTE 370 380 390 400 410 420 GDQDDRSYKQ CRTSSPSSTG SVSLGRYTPT SRSPQHYSRP AARRSDGEDG SLDQDNRKKS 430 440 450 460 470 480 SWLMLKGDAD TRTNSPDLDT QSLSHSSGTD RDPLQRMAGD SFHSQYKIYP YDSLIVTNRI 490 500 510 520 530 RVKLPKDVDR TRLERHLSPE EFQEVFGMSI EEFDRLALWK RNDLKKKALL F
	Isoform 4 [UniParc]. Checksum: 00733A9BC0EA7BE5	FASTA	346	38,966
	10 20 30 40 50 60 MFAEGEEMYL QGSSIWHPAC RQAARTEDRN KETRTSSESI ISVPASSTSG SPSRVIYAKL 70 80 90 100 110 120 GGEILDYRDL AALPKSKAIY DIDRPDMISY SPYISHSAGD RQSYGESPQL LSPTPTEGDQ 130 140 150 160 170 180 DDRSYKQCRT SSPSSTGSVS LGRYTPTSRS PQHYSRPDTG VKDNIYRKPP IYRQHAARRS 190 200 210 220 230 240 DGEDGSLDQD NRKQKSSWLM LKGDADTRTN SPDLDTQSLS HSSGTDRDPL QRMAGDSFHS 250 260 270 280 290 300 RFPYSKSDPL PGHGKNGLDQ RNANLAPCGA DPDASWGMRE YKIYPYDSLI VTNRIRVKLP 310 320 330 340 KDVDRTRLER HLSPEEFQEV FGMSIEEFDR LALWKRNDLK KKALLF
	Isoform 5 [UniParc]. Checksum: DFD6CB38CF846982	FASTA	573	63,760
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 370 380 390 400 410 420 RTSSPSSTGS VSLGRYTPTS RSPQHYSRPG SESGRSTPSL SVLSDSKPPP STYQQAPRHF 430 440 450 460 470 480 HVPDTGVKDN IYRKPPIYRQ HAARRSDGED GSLDQDNRKQ KSSWLMLKGD ADTRTNSPDL 490 500 510 520 530 540 DTQSLSHSSG TDRDPLQRMA GDSFHSQYKI YPYDSLIVTN RIRVKLPKDV DRTRLERHLS 550 560 570 PEEFQEVFGM SIEEFDRLAL WKRNDLKKKA LLF
	Isoform 6 [UniParc]. Checksum: FD93E620E09C0742	FASTA	470	51,698
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGES PQLLSPTPTE 370 380 390 400 410 420 GDQDDRSYKQ CRTSSPSSTG SVSLGRYTPT SRSPQHYSRP AARRSDGEDG SLDQDNRKQK 430 440 450 460 470 SSWLMLKGDA DTRTNSPDLD TQSLSHSSGT DRDPLQRMAG DSFHSREWFF
	Isoform 7 [UniParc]. Checksum: A055D0C31DE338FA	FASTA	559	62,013
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 370 380 390 400 410 420 RTSSPSSTGS VSLGRYTPTS RSPQHYSRPA ARRSDGEDGS LDQDNRKKSS WLMLKGDADT 430 440 450 460 470 480 RTNSPDLDTQ SLSHSSGTDR DPLQRMAGDS FHSRFPYSKS DPLPGHGKNG LDQRNANLAP 490 500 510 520 530 540 CGADPDASWG MREYKIYPYD SLIVTNRIRV KLPKDVDRTR LERHLSPEEF QEVFGMSIEE 550 FDRLALWKRN DLKKKALLF
	Isoform 8 [UniParc]. Checksum: 1A242FA6173188E3	FASTA	521	57,960
	10 20 30 40 50 60 MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC KACGCDLAEG 70 80 90 100 110 120 GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK TYHPDCFVCA VCRLPFPPGD 130 140 150 160 170 180 RVTFNGKECM CQKCSLPVSV GSSAHLSQGL RSCGGCGTEI KNGQALVALD KHWHLGCFKC 190 200 210 220 230 240 KSCGKLLNAE YISKDGLPYC EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR 250 260 270 280 290 300 CGQMFAEGEE MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY 310 320 330 340 350 360 AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG DQDDRSYKQC 370 380 390 400 410 420 RTSSPSSTGS VSLGRYTPTS RSPQHYSRPA ARRSDGEDGS LDQDNRKQKS SWLMLKGDAD 430 440 450 460 470 480 TRTNSPDLDT QSLSHSSGTD RDPLQRMAGD SFHSQYKIYP YDSLIVTNRI RVKLPKDVDR 490 500 510 520 TRLERHLSPE EFQEVFGMSI EEFDRLALWK RNDLKKKALL F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin." Barrientos T., Frank D., Kuwahara K., Bezprozvannaya S., Pipes G.C.T., Bassel-Duby R., Richardson J.A., Katus H.A., Olson E.N., Frey N. J. Biol. Chem. 282:8393-8403(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH ABRA AND F-ACTIN. Tissue: Heart.
[2]	"Structure and transcriptional activity of the ABLIM2 gene of human, mouse and rat." Klimov E.A., Rakhmanaliev E.R., Rudco O.I. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Brain.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 8). Tissue: PNS.
[6]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-611 (ISOFORM 2). Tissue: Brain.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 390-572 (ISOFORM 5). Tissue: Amygdala.
[8]	"Solution structure of the LIM domain of the human actin binding LIM protein 2." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2009) to the PDB data bank Cited for: STRUCTURE BY NMR OF 73-140 AND 212-271, ZINC-BINDING SITES.
[9]	"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses." Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., Hong S.M., Fu B., Lin M.T., Calhoun E.S., Kamiyama M., Walter K., Nikolskaya T., Nikolsky Y. , Hartigan J., Smith D.R., Hidalgo M., Leach S.D., Klein A.P., Jaffee E.M., Goggins M., Maitra A., Iacobuzio-Donahue C., Eshleman J.R., Kern S.E., Hruban R.H., Karchin R., Papadopoulos N., Parmigiani G., Vogelstein B., Velculescu V.E., Kinzler K.W. Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-227 AND MET-274.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ413177 mRNA. Translation: ABD83330.1.
AJ748600 mRNA. Translation: CAG38375.1.
AJ748601 mRNA. Translation: CAG38376.1.
AK094754 mRNA. Translation: BAC04414.1.
AK094798 mRNA. Translation: BAC04427.1.
AC097381 Genomic DNA. No translation available.
AC104650 Genomic DNA. No translation available.
AC114807 Genomic DNA. No translation available.
BC067214 mRNA. Translation: AAH67214.1. Different initiation.
BC122567 mRNA. Translation: AAI22568.1.
AB058711 mRNA. Translation: BAB47437.1.
AL834195 mRNA. Translation: CAD38885.2.

IPI

IPI00167702.
IPI00187164.
IPI00434484.
IPI00479275.
IPI00761095.
IPI00892702.
IPI00902561.
IPI00910569.

RefSeq

NP_001123555.1. NM_001130083.1.
NP_001123556.1. NM_001130084.1.
NP_001123557.1. NM_001130085.1.
NP_001123558.1. NM_001130086.1.
NP_001123559.1. NM_001130087.1.
NP_001123560.1. NM_001130088.1.
NP_115808.3. NM_032432.4.

UniGene

Hs.233404.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V6G	NMR	-	A	73-140	[»]
1WIG	NMR	-	A	212-271	[»]
2L3X	NMR	-	A	546-611	[»]

ProteinModelPortal

Q6H8Q1.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q6H8Q1. 3 interactions.

STRING

9606.ENSP00000393511.

PTM databases

PhosphoSite

Q6H8Q1.

Polymorphism databases

DMDM

56404514.

Proteomic databases

PaxDb

Q6H8Q1.

PRIDE

Q6H8Q1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000318888; ENSP00000317020; ENSG00000163995.
ENST00000341937; ENSP00000342813; ENSG00000163995.
ENST00000361581; ENSP00000355003; ENSG00000163995.
ENST00000361737; ENSP00000354887; ENSG00000163995.
ENST00000407564; ENSP00000384658; ENSG00000163995.
ENST00000428004; ENSP00000389410; ENSG00000163995.
ENST00000505872; ENSP00000421283; ENSG00000163995.
ENST00000514025; ENSP00000423661; ENSG00000163995.

GeneID

84448.

KEGG

hsa:84448.

UCSC

uc003gkl.3. human.
uc003gko.3. human.
uc003gkp.3. human.
uc003gkq.3. human.
uc003gks.3. human.

Organism-specific databases

CTD

84448.

GeneCards

GC04M007967.

HGNC

HGNC:19195. ABLIM2.

HPA

HPA035808.

MIM

612544. gene.

neXtProt

NX_Q6H8Q1.

PharmGKB

PA134940437.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG302299.

HOGENOM

HOG000285997.

HOVERGEN

HBG031499.

KO

K07520.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q6H8Q1.

Bgee

Q6H8Q1.

CleanEx

HS_ABLIM2.

Genevestigator

Q6H8Q1.

GermOnline

ENSG00000163995. Homo sapiens.

Family and domain databases

Gene3D

1.10.950.10. 1 hit.
2.10.110.10. 4 hits.

InterPro

IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]

Pfam

PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]

SMART

SM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]

SUPFAM

SSF47050. VHP. 1 hit.

PROSITE

PS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q6H8Q1.

GenomeRNAi

84448.

NextBio

74223.

SOURCE

Search...

Entry information

Entry name

ABLM2_HUMAN

Accession

Primary (citable) accession number: Q6H8Q1
Secondary accession number(s): Q08E71 , Q19VH0, Q6H8Q0, Q6NX73, Q8N3C5, Q8N9E9, Q8N9G2, Q96JL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.