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Protein

Actin-binding LIM protein 2

Gene

ABLIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc 11
Metal bindingi86Zinc 11
Metal bindingi103Zinc 11
Metal bindingi106Zinc 11
Metal bindingi109Zinc 21
Metal bindingi112Zinc 21
Metal bindingi131Zinc 21
Metal bindingi134Zinc 21
Metal bindingi212Zinc 31
Metal bindingi215Zinc 31
Metal bindingi232Zinc 31
Metal bindingi235Zinc 31
Metal bindingi238Zinc 41
Metal bindingi241Zinc 41
Metal bindingi260Zinc 41
Metal bindingi263Zinc 41

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-418885 DCC mediated attractive signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 2
Short name:
abLIM-2
Alternative name(s):
Actin-binding LIM protein family member 2
Gene namesi
Name:ABLIM2
Synonyms:KIAA1808
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163995.18
HGNCiHGNC:19195 ABLIM2
MIMi612544 gene
neXtProtiNX_Q6H8Q1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84448
OpenTargetsiENSG00000163995
PharmGKBiPA134940437

Polymorphism and mutation databases

BioMutaiABLIM2
DMDMi56404514

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000756991 – 611Actin-binding LIM protein 2Add BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei472PhosphothreonineBy similarity1
Modified residuei476PhosphoserineBy similarity1
Modified residuei578PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6H8Q1
PeptideAtlasiQ6H8Q1
PRIDEiQ6H8Q1
ProteomicsDBi66340
66341 [Q6H8Q1-2]
66342 [Q6H8Q1-3]
66343 [Q6H8Q1-4]
66344 [Q6H8Q1-5]
66345 [Q6H8Q1-6]
66346 [Q6H8Q1-7]
66347 [Q6H8Q1-8]

PTM databases

iPTMnetiQ6H8Q1
PhosphoSitePlusiQ6H8Q1

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000163995
CleanExiHS_ABLIM2
ExpressionAtlasiQ6H8Q1 baseline and differential
GenevisibleiQ6H8Q1 HS

Organism-specific databases

HPAiHPA035808

Interactioni

Subunit structurei

Interacts with F-actin and ABRA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124086, 7 interactors
IntActiQ6H8Q1, 5 interactors

Structurei

Secondary structure

1611
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi75 – 77Combined sources3
Turni84 – 86Combined sources3
Beta strandi95 – 97Combined sources3
Beta strandi100 – 102Combined sources3
Turni104 – 106Combined sources3
Beta strandi110 – 112Combined sources3
Beta strandi118 – 120Combined sources3
Beta strandi122 – 125Combined sources4
Beta strandi128 – 131Combined sources4
Helixi132 – 135Combined sources4
Beta strandi213 – 215Combined sources3
Turni233 – 235Combined sources3
Beta strandi239 – 241Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi257 – 259Combined sources3
Helixi263 – 266Combined sources4
Beta strandi268 – 271Combined sources4
Helixi551 – 554Combined sources4
Helixi556 – 558Combined sources3
Turni559 – 561Combined sources3
Beta strandi570 – 572Combined sources3
Helixi573 – 576Combined sources4
Helixi579 – 586Combined sources8
Helixi590 – 595Combined sources6
Helixi598 – 607Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V6GNMR-A73-140[»]
1WIGNMR-A212-271[»]
2L3XNMR-A546-611[»]
ProteinModelPortaliQ6H8Q1
SMRiQ6H8Q1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6H8Q1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 81LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini81 – 141LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini151 – 210LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini210 – 270LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini543 – 611HPPROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ6H8Q1
KOiK07520
PhylomeDBiQ6H8Q1
TreeFamiTF318042

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028450 ABLIM2
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF6 PTHR24213:SF6, 2 hits
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 2 hits
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6H8Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAVSQPQAA PSPLEKSPST AILCNTCGNV CKGEVLRVQD KYFHIKCFVC
60 70 80 90 100
KACGCDLAEG GFFVRQGEYI CTLDYQRLYG TRCFSCDQFI EGEVVSALGK
110 120 130 140 150
TYHPDCFVCA VCRLPFPPGD RVTFNGKECM CQKCSLPVSV GSSAHLSQGL
160 170 180 190 200
RSCGGCGTEI KNGQALVALD KHWHLGCFKC KSCGKLLNAE YISKDGLPYC
210 220 230 240 250
EADYHAKFGI RCDSCEKYIT GRVLEAGEKH YHPSCALCVR CGQMFAEGEE
260 270 280 290 300
MYLQGSSIWH PACRQAARTE DRNKETRTSS ESIISVPASS TSGSPSRVIY
310 320 330 340 350
AKLGGEILDY RDLAALPKSK AIYDIDRPDM ISYSPYISHS AGDRQSYGEG
360 370 380 390 400
DQDDRSYKQC RTSSPSSTGS VSLGRYTPTS RSPQHYSRPG SESGRSTPSL
410 420 430 440 450
SVLSDSKPPP STYQQAPRHF HVPDTGVKDN IYRKPPIYRQ HAARRSDGED
460 470 480 490 500
GSLDQDNRKK SSWLMLKGDA DTRTNSPDLD TQSLSHSSGT DRDPLQRMAG
510 520 530 540 550
DSFHSRFPYS KSDPLPGHGK NGLDQRNANL APCGADPDAS WGMREYKIYP
560 570 580 590 600
YDSLIVTNRI RVKLPKDVDR TRLERHLSPE EFQEVFGMSI EEFDRLALWK
610
RNDLKKKALL F
Length:611
Mass (Da):67,812
Last modified:December 7, 2004 - v2
Checksum:i225A4E25646B370B
GO
Isoform 2 (identifier: Q6H8Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Show »
Length:572
Mass (Da):63,632
Checksum:iF2CF3EEE6B1CCADC
GO
Isoform 3 (identifier: Q6H8Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: E → ESPQLLSPTPTE
     390-441: Missing.
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Show »
Length:531
Mass (Da):58,984
Checksum:i1E6B36B85E5176D8
GO
Isoform 4 (identifier: Q6H8Q1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     349-349: E → ESPQLLSPTPTE
     389-422: Missing.
     459-459: K → KQ

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):38,966
Checksum:i00733A9BC0EA7BE5
GO
Isoform 5 (identifier: Q6H8Q1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: K → KQ
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Note: No experimental confirmation available.
Show »
Length:573
Mass (Da):63,760
Checksum:iDFD6CB38CF846982
GO
Isoform 6 (identifier: Q6H8Q1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: E → ESPQLLSPTPTE
     390-441: Missing.
     459-459: K → KQ
     507-510: FPYS → EWFF
     511-611: Missing.

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):51,698
Checksum:iFD93E620E09C0742
GO
Isoform 7 (identifier: Q6H8Q1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-441: Missing.

Show »
Length:559
Mass (Da):62,013
Checksum:iA055D0C31DE338FA
GO
Isoform 8 (identifier: Q6H8Q1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-441: Missing.
     459-459: K → KQ
     506-545: RFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDASWGMRE → Q

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):57,960
Checksum:i1A242FA6173188E3
GO
Isoform 9 (identifier: Q6H8Q1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-389: P → PAGTVSVGTSSCLSLSQHPSPTSVFRHHYIPYFR
     459-459: K → KQ

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):71,542
Checksum:i50C4FDC1B30AD41E
GO

Sequence cautioni

The sequence AAH67214 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240R → G in BAC04414 (PubMed:14702039).Curated1
Sequence conflicti312D → G in BAC04414 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062665227G → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs757430763Ensembl.1
Natural variantiVAR_062666274K → M in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0121121 – 243Missing in isoform 4. 1 PublicationAdd BLAST243
Alternative sequenceiVSP_012113349E → ESPQLLSPTPTE in isoform 3, isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_012114389 – 422Missing in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_046646389P → PAGTVSVGTSSCLSLSQHPS PTSVFRHHYIPYFR in isoform 9. Curated1
Alternative sequenceiVSP_012115390 – 441Missing in isoform 3, isoform 6, isoform 7 and isoform 8. 3 PublicationsAdd BLAST52
Alternative sequenceiVSP_012116459K → KQ in isoform 4, isoform 5, isoform 6, isoform 8 and isoform 9. 3 Publications1
Alternative sequenceiVSP_012117506 – 545RFPYS…WGMRE → Q in isoform 2, isoform 3, isoform 5 and isoform 8. 5 PublicationsAdd BLAST40
Alternative sequenceiVSP_012118507 – 510FPYS → EWFF in isoform 6. 1 Publication4
Alternative sequenceiVSP_012119511 – 611Missing in isoform 6. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ413177 mRNA Translation: ABD83330.1
AJ748600 mRNA Translation: CAG38375.1
AJ748601 mRNA Translation: CAG38376.1
AK094754 mRNA Translation: BAC04414.1
AK094798 mRNA Translation: BAC04427.1
AC097381 Genomic DNA No translation available.
AC104650 Genomic DNA No translation available.
AC114807 Genomic DNA No translation available.
BC067214 mRNA Translation: AAH67214.1 Different initiation.
BC122567 mRNA Translation: AAI22568.1
AB058711 mRNA Translation: BAB47437.1
AL834195 mRNA Translation: CAD38885.2
CCDSiCCDS47011.1 [Q6H8Q1-7]
CCDS47012.1 [Q6H8Q1-2]
CCDS47013.1 [Q6H8Q1-1]
CCDS47014.1 [Q6H8Q1-9]
CCDS47015.1 [Q6H8Q1-3]
CCDS47016.1 [Q6H8Q1-6]
CCDS54719.1 [Q6H8Q1-8]
CCDS68669.1 [Q6H8Q1-4]
RefSeqiNP_001123555.1, NM_001130083.1 [Q6H8Q1-9]
NP_001123556.1, NM_001130084.1 [Q6H8Q1-1]
NP_001123557.1, NM_001130085.1 [Q6H8Q1-2]
NP_001123558.1, NM_001130086.1 [Q6H8Q1-7]
NP_001123559.1, NM_001130087.1 [Q6H8Q1-3]
NP_001123560.1, NM_001130088.1 [Q6H8Q1-6]
NP_001273617.1, NM_001286688.1 [Q6H8Q1-4]
NP_115808.3, NM_032432.4 [Q6H8Q1-8]
UniGeneiHs.233404

Genome annotation databases

EnsembliENST00000341937; ENSP00000342813; ENSG00000163995 [Q6H8Q1-1]
ENST00000361581; ENSP00000355003; ENSG00000163995 [Q6H8Q1-2]
ENST00000361737; ENSP00000354887; ENSG00000163995 [Q6H8Q1-3]
ENST00000407564; ENSP00000384658; ENSG00000163995 [Q6H8Q1-8]
ENST00000428004; ENSP00000389410; ENSG00000163995 [Q6H8Q1-6]
ENST00000447017; ENSP00000393511; ENSG00000163995 [Q6H8Q1-9]
ENST00000505872; ENSP00000421283; ENSG00000163995 [Q6H8Q1-7]
ENST00000514025; ENSP00000423661; ENSG00000163995 [Q6H8Q1-4]
GeneIDi84448
KEGGihsa:84448
UCSCiuc003gkj.5 human [Q6H8Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABLM2_HUMAN
AccessioniPrimary (citable) accession number: Q6H8Q1
Secondary accession number(s): E9PF39
, Q08E71, Q19VH0, Q6H8Q0, Q6NX73, Q8N3C5, Q8N9E9, Q8N9G2, Q96JL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 20, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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