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Q6H8M7 (SIA10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Type 2 lactosamine alpha-2,3-sialyltransferase
EC=2.4.99.-
Alternative name(s):
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
Short name=ST3GalVI
Sialyltransferase 10
Gene names
Name:ST3GAL6
Synonyms:SIAT10
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 By similarity.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Type 2 lactosamine alpha-2,3-sialyltransferase
PRO_0000331505

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain26 – 331306Lumenal Potential

Amino acid modifications

Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation2821N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6H8M7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 38C84D922C50C19B

FASTA33138,224
        10         20         30         40         50         60 
MRGYLLAIFL SAVFLYYVLH CILWRTNDYG VTPMEMKQRN KIRSCLSKPA FASLLRYHQF 

        70         80         90        100        110        120 
HPFLCAANFK NTASFYGSDK FDLPYGMKAS ATHFRLALWK LPNCDIFDEF DNVPCKKCVV 

       130        140        150        160        170        180 
VGNGGILKNK TLGEKIDSYD VIIRMNNGPV LGHEEEVGRR TTFRLFYPES VFSDPNHNDP 

       190        200        210        220        230        240 
NTTVILTAFK PLDLKWLWEL LTGGKISPNG FWKEPALNLI YKPYQIRILD PYITRMAAYE 

       250        260        270        280        290        300 
LLHFPKVFPK NQKPKHPTTG IIAITLAFHI CHEVHLAGFK YNFSDLKSPL HYYGNATMSL 

       310        320        330 
MSENEYHNVT AEQLFLKDII EKNFVTDLTQ E

« Hide

References

« Hide 'large scale' references
[1]"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ748843 mRNA. Translation: CAG44452.1.
BC133294 mRNA. Translation: AAI33295.1.
IPIIPI00686390.
RefSeqNP_001002883.1. NM_001002883.2.
UniGeneBt.64658.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6H8M7.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

Proteomic databases

PRIDEQ6H8M7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000005868; ENSBTAP00000005868; ENSBTAG00000004471.
GeneID444860.
KEGGbta:444860.

Organism-specific databases

CTD10402.

Phylogenomic databases

eggNOGmaNOG14418.
GeneTreeENSGT00550000074199.
HOVERGENHBG056676.
InParanoidQ6H8M7.
OMAPNTTAIL.
OrthoDBEOG4W6NWB.
PhylomeDBQ6H8M7.

Family and domain databases

InterProIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
KOK03792.
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSIA10_BOVIN
AccessionPrimary (citable) accession number: Q6H8M7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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