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Reviewed, UniProtKB/Swiss-Prot Q6H8M7 (SIA10_BOVIN)

Last modified November 24, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Type 2 lactosamine alpha-2,3-sialyltransferase
    EC=2.4.99.-
Alternative name(s):
    CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
    ST3Gal VI
    Sialyltransferase 10
Gene names
Name: ST3GAL6
Synonyms: SIAT10
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 By similarity.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

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Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   DomainSignal-anchor
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processprotein amino acid glycosylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to Golgi membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functionsialyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Type 2 lactosamine alpha-2,3-sialyltransferase
PRO_0000331505

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2521Signal-anchor for type II membrane protein Potential
Topological domain26 – 331306Lumenal Potential

Amino acid modifications

Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation2821N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q6H8M7-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 38C84D922C50C19B

FASTA33138,224
        10         20         30         40         50         60 
MRGYLLAIFL SAVFLYYVLH CILWRTNDYG VTPMEMKQRN KIRSCLSKPA FASLLRYHQF 

        70         80         90        100        110        120 
HPFLCAANFK NTASFYGSDK FDLPYGMKAS ATHFRLALWK LPNCDIFDEF DNVPCKKCVV 

       130        140        150        160        170        180 
VGNGGILKNK TLGEKIDSYD VIIRMNNGPV LGHEEEVGRR TTFRLFYPES VFSDPNHNDP 

       190        200        210        220        230        240 
NTTVILTAFK PLDLKWLWEL LTGGKISPNG FWKEPALNLI YKPYQIRILD PYITRMAAYE 

       250        260        270        280        290        300 
LLHFPKVFPK NQKPKHPTTG IIAITLAFHI CHEVHLAGFK YNFSDLKSPL HYYGNATMSL 

       310        320        330 
MSENEYHNVT AEQLFLKDII EKNFVTDLTQ E

« Hide

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References

« Hide 'large scale' references
[1]"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal muscle.

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Cross-references

Sequence databases

AJ748843 mRNA. Translation: CAG44452.1.
BC133294 mRNA. Translation: AAI33295.1.
IPIIPI00686390.
RefSeqNP_001002883.1.
UniGeneBt.64658

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6H8M7.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

Genome annotation databases

EnsemblENSBTAT00000005868; ENSBTAP00000005868; ENSBTAG00000004471; Bos taurus. [Genome view]
GeneID444860.
KEGGbta:444860.

Organism-specific databases

CTD444860.

Phylogenomic databases

HOVERGENQ6H8M7.
OMAAILTAFK
OrthoDBEOG9PP12T

Family and domain databases

InterProIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameSIA10_BOVIN
AccessionPrimary (citable) accession number: Q6H8M7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2004
Last modified: November 24, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents