ID FABI2_ORYSJ Reviewed; 371 AA. AC Q6H5J0; A0A0P0XJW8; DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot. DT 19-JUL-2004, sequence version 1. DT 24-JAN-2024, entry version 125. DE RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH] 2, chloroplastic; DE Short=ENR; DE EC=1.3.1.9; DE AltName: Full=NADH-dependent enoyl-ACP reductase; DE Flags: Precursor; GN OrderedLocusNames=Os09g0277800, LOC_Os09g10600; ORFNames=P0701E06.10; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=24280374; DOI=10.1186/1939-8433-6-4; RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R., RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L., RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H., RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.; RT "Improvement of the Oryza sativa Nipponbare reference genome using next RT generation sequence and optical map data."; RL Rice 6:4-4(2013). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Nipponbare; RX PubMed=12869764; DOI=10.1126/science.1081288; RG The rice full-length cDNA consortium; RT "Collection, mapping, and annotation of over 28,000 cDNA clones from RT japonica rice."; RL Science 301:376-379(2003). CC -!- FUNCTION: Catalyzes the NAD-dependent reduction of a carbon-carbon CC double bond in an enoyl moiety that is covalently linked to an acyl CC carrier protein (ACP). Catalyzes the last reduction step in the de novo CC synthesis cycle of fatty acids. Involved in the elongation cycle of CC fatty acids which are used in lipid metabolism. Required for normal CC plant growth (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + CC H(+) + NADH; Xref=Rhea:RHEA:10240, Rhea:RHEA-COMP:9925, Rhea:RHEA- CC COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.9; CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC -!- SUBUNIT: Homotetramer. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000305}. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) CC family. FabI subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP005594; BAD26009.1; -; Genomic_DNA. DR EMBL; AP008215; BAF24666.1; -; Genomic_DNA. DR EMBL; AP014965; BAT07201.1; -; Genomic_DNA. DR EMBL; AK103141; BAG95916.1; -; mRNA. DR RefSeq; XP_015610600.1; XM_015755114.1. DR AlphaFoldDB; Q6H5J0; -. DR SMR; Q6H5J0; -. DR STRING; 39947.Q6H5J0; -. DR PaxDb; 39947-Q6H5J0; -. DR EnsemblPlants; Os09t0277800-01; Os09t0277800-01; Os09g0277800. DR GeneID; 4346596; -. DR Gramene; Os09t0277800-01; Os09t0277800-01; Os09g0277800. DR KEGG; osa:4346596; -. DR eggNOG; KOG0725; Eukaryota. DR HOGENOM; CLU_010194_10_0_1; -. DR InParanoid; Q6H5J0; -. DR OMA; DWMGPAK; -. DR OrthoDB; 5485040at2759; -. DR UniPathway; UPA00094; -. DR Proteomes; UP000000763; Chromosome 9. DR Proteomes; UP000059680; Chromosome 9. DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell. DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:UniProtKB-EC. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd05372; ENR_SDR; 1. DR Gene3D; 1.10.8.400; Enoyl acyl carrier protein reductase; 1. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR002347; SDR_fam. DR PANTHER; PTHR43159; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE; 1. DR PANTHER; PTHR43159:SF7; ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] 2, CHLOROPLASTIC; 1. DR Pfam; PF13561; adh_short_C2; 1. DR PRINTS; PR00081; GDHRDH. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. DR Genevisible; Q6H5J0; OS. PE 2: Evidence at transcript level; KW Chloroplast; Fatty acid biosynthesis; Fatty acid metabolism; KW Lipid biosynthesis; Lipid metabolism; NAD; Oxidoreductase; Plastid; KW Reference proteome; Transit peptide. FT TRANSIT 1..67 FT /note="Chloroplast" FT /evidence="ECO:0000255" FT CHAIN 68..371 FT /note="Enoyl-[acyl-carrier-protein] reductase [NADH] 2, FT chloroplastic" FT /id="PRO_0000420280" FT ACT_SITE 250 FT /note="Proton acceptor" FT /evidence="ECO:0000250" FT ACT_SITE 260 FT /note="Proton acceptor" FT /evidence="ECO:0000250" FT BINDING 87 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 94 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 151..152 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 198..199 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 248 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 268 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 298..302 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" SQ SEQUENCE 371 AA; 39021 MW; 7AEE27D8CBC35E68 CRC64; MGASVTTGLQ MAAARPCIPA CQRLLGSRAA LPSFGRALST QTGFASCRKT ASAGPFVSLN HKRFAVRAMS AQGLPIDLRG KRAFIAGVAD DNGYGWAIAK ALAAAGAEIL VGTWVPALNI FETSLRRGKF DESRKLPDGS LMEITKVYPL DAVFDSPEDV PDDVKANKRY AGSSNWTVKE VAETVKNDFG TIDILVHSLA NGPEVKNSLL ETSRKGYLAA VSASSYSFIS LLQHFLPIMN PGGATISLTY IASERTIPGY GGGMSSAKAA LESDTRVLAY EAGRKGKIRV NTISAGPLGS RAAKAIGFIE KMIEYSYVNA PLQKELLADE VGNTAAFLAS PLASAITGST IYVDNGLNTM GLALDSPTLS T //