Q6H501 (HKT6_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cation transporter HKT6
Short name=OsHKT6

Gene names

Name:	HKT6
Ordered Locus Names:	Os02g0175000, LOC_Os02g07830
ORF Names:	OSJNBa0073A21.31

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable cation transporter. May be involved in regulation of K+/Na+ homeostasis.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Weakly expressed. Ref.1
Domain	HKT transporters are proposed to contain 4 pore-forming regions enclosed by transmembrane segments with each containing a potassium channel-like selectivity filter motif.
Sequence similarities	Belongs to the TrkH potassium transport family. HKT (TC 2.A.38.3) subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	potassium ion transport Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to salt stress Inferred from electronic annotation. Source: EnsemblPlants/Gramene sodium ion transport Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Molecular_function	cation transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Probable cation transporter HKT6		PRO_0000070470
Regions
	Topological domain	1 – 46	46	Cytoplasmic Potential
	Transmembrane	47 – 67	21	Helical; Name=1; Potential
	Transmembrane	108 – 128	21	Helical; Name=2; Potential
	Topological domain	129 – 190	62	Cytoplasmic Potential
	Transmembrane	191 – 211	21	Helical; Name=3; Potential
	Transmembrane	264 – 284	21	Helical; Name=4; Potential
	Topological domain	285 – 321	37	Cytoplasmic Potential
	Transmembrane	322 – 342	21	Helical; Name=5; Potential
	Transmembrane	383 – 403	21	Helical; Name=6; Potential
	Topological domain	404 – 421	18	Cytoplasmic Potential
	Transmembrane	422 – 442	21	Helical; Name=7; Potential
	Transmembrane	494 – 514	21	Helical; Name=8; Potential
	Topological domain	515 – 530	16	Cytoplasmic Potential
Experimental info
	Sequence conflict	465	1	V → VS in CAD37184. Ref.1
	Sequence conflict	465	1	V → VS in CAD37185. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6H501 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1ECC845AA8677C44	FASTA	530	59,217
	10 20 30 40 50 60 MNHCLVVSHK KLQTFRTFAA SKFSSFTKSA QKSIKYSFQF IYQNNPLFVH VAYFALISFA 70 80 90 100 110 120 GYGSLKVLKP RDKSNTLKDL DVLFTSVSAS TVSSMATVEM EDFSSAQLWV LTILMLIGGE 130 140 150 160 170 180 VFTSMLGIHF MRAEFGTKES VSTRDHSPCI DIESITSTKF GPSTQGTKVT VSFSELRMEN 190 200 210 220 230 240 GGHVEPKTIK FLGFVVMGYL LITNLGGSLL IYLYLNLVPS AHKILKRKGI GIIVFSVFTA 250 260 270 280 290 300 ISSVGNCGFT PVNENMIIFQ KNSILLLLIL PQILAGNTLF APCLRLMVWS LEKITGKKDC 310 320 330 340 350 360 RYILEYPKAI GYKHLMSTRE SVYLTLTVVS LIILQTVLFL SLEWSSVALD GMSNYQKIVS 370 380 390 400 410 420 ALFQSVNARH AGESVTDLSN LSSAILVLYT IMMYLPGYTS FLPRHDGEDS KTEKINKRKG 430 440 450 460 470 480 LLENWIFSHM SYLAIFVMLI CITERDSMAT DPLNFNVFSI LFEVVAYGNV GFSVGYSCKR 490 500 510 520 530 LLNHDARCKD ASYGFAGKWS DNGKAILIIV MLFGRLKTFN MKGGRAWKLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sodium transport and HKT transporters: the rice model." Garciadeblas B., Senn M.E., Banuelos M.A., Rodriguez-Navarro A. Plant J. 34:788-801(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, NOMENCLATURE. Strain: cv. Nipponbare. Tissue: Root.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ491817 Genomic DNA. Translation: CAD37184.1. AJ491818 mRNA. Translation: CAD37185.1. AP005772 Genomic DNA. Translation: BAD26198.1. AP003992 Genomic DNA. Translation: BAD27606.1.
RefSeq	NP_001046052.1. NM_001052587.1.
UniGene	Os.79807.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4328468.
KEGG	osa:4328468.
Organism-specific databases
Gramene	Q6H501.
Phylogenomic databases
eggNOG	COG0168.
ProtClustDB	CLSN2692487.
Gene expression databases
ArrayExpress	Q6H501.
Family and domain databases
InterPro	IPR003445. Cat_transpt. [Graphical view]
Pfam	PF02386. TrkH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HKT6_ORYSJ

Accession

Primary (citable) accession number: Q6H501
Secondary accession number(s): Q8L4V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 19, 2004
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program