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Protein

Retinoic acid early transcript 1G protein

Gene

RAET1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.1 Publication

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33357-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid early transcript 1G protein
Alternative name(s):
UL-16 binding protein 5
Short name:
ULBP5
Gene namesi
Name:RAET1GImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:16795. RAET1G.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 223ExtracellularSequence analysisAdd BLAST198
Transmembranei224 – 243HelicalSequence analysisAdd BLAST20
Topological domaini244 – 334CytoplasmicSequence analysisAdd BLAST91

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi217S → P: Reduced cell surface expression. 1 Publication1

Organism-specific databases

DisGeNETi353091.
OpenTargetsiENSG00000203722.
PharmGKBiPA134897742.

Polymorphism and mutation databases

BioMutaiRAET1G.
DMDMi56749591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001902226 – 218Retinoic acid early transcript 1G proteinAdd BLAST193
PropeptideiPRO_0000429932219 – 334Removed in mature formSequence analysisAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66By similarity
Glycosylationi82N-linked (GlcNAc...)1 Publication1
Disulfide bondi127 ↔ 190By similarity
Lipidationi218GPI-anchor amidated glycine1 Publication1

Post-translational modificationi

The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ6H3X3.
PaxDbiQ6H3X3.
PeptideAtlasiQ6H3X3.
PRIDEiQ6H3X3.
TopDownProteomicsiQ6H3X3-1. [Q6H3X3-1]

PTM databases

iPTMnetiQ6H3X3.
PhosphoSitePlusiQ6H3X3.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.2 Publications

Gene expression databases

BgeeiENSG00000203722.
ExpressionAtlasiQ6H3X3. baseline and differential.

Organism-specific databases

HPAiHPA062673.

Interactioni

Subunit structurei

Binds to KLRK1/NKG2D. Also binds the CMV glycoprotein UL16.1 Publication

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

Protein-protein interaction databases

IntActiQ6H3X3. 1 interactor.
STRINGi9606.ENSP00000356329.

Structurei

3D structure databases

ProteinModelPortaliQ6H3X3.
SMRiQ6H3X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 117MHC class I alpha-1 likeAdd BLAST89
Regioni118 – 210MHC class I alpha-2 likeAdd BLAST93

Sequence similaritiesi

Belongs to the MHC class I family.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4VC. Eukaryota.
ENOG41113ZC. LUCA.
GeneTreeiENSGT00390000003472.
HOGENOMiHOG000070028.
InParanoidiQ6H3X3.
KOiK07987.
OMAiQIAKRPL.
OrthoDBiEOG091G0I62.
PhylomeDBiQ6H3X3.
TreeFamiTF341724.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6H3X3-1) [UniParc]FASTAAdd to basket
Also known as: RAET1G11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC
60 70 80 90 100
AVQGQVDEKT FLHYDCGSKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI
110 120 130 140 150
LTEQLLDIQL ENYIPKEPLT LQARMSCEQK AEGHGSGSWQ LSFDGQIFLL
160 170 180 190 200
FDSENRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TGWLEDFLMG
210 220 230 240 250
MDSTLEPSAG APPTMSSGTA QPRATATTLI LCCLLIMCLL ICSRHSLTQS
260 270 280 290 300
HGHHPQSLQP PPHPPLLHPT WLLRRVLWSD SYQIAKRPLS GGHVTRVTLP
310 320 330
IIGDDSHSLP CPLALYTINN GAARYSEPLQ VSIS
Length:334
Mass (Da):37,106
Last modified:July 19, 2004 - v1
Checksum:i3F8350036951BA69
GO
Isoform 21 Publication (identifier: Q6H3X3-2) [UniParc]FASTAAdd to basket
Also known as: RAET1G21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     211-213: APP → GTV
     214-334: Missing.

Show »
Length:213
Mass (Da):23,884
Checksum:i24E4AC61CE0F8854
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03344970T → R.Corresponds to variant rs9397449dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051621211 – 213APP → GTV in isoform 2. 1 Publication3
Alternative sequenceiVSP_051622214 – 334Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172579 mRNA. Translation: AAO22238.1.
AY172580 mRNA. Translation: AAO22239.1.
CCDSiCCDS43514.1. [Q6H3X3-1]
RefSeqiNP_001001788.2. NM_001001788.3. [Q6H3X3-1]
UniGeneiHs.535023.
Hs.558792.

Genome annotation databases

EnsembliENST00000367360; ENSP00000356329; ENSG00000203722. [Q6H3X3-1]
ENST00000367361; ENSP00000356330; ENSG00000203722. [Q6H3X3-2]
GeneIDi353091.
KEGGihsa:353091.
UCSCiuc010kii.1. human. [Q6H3X3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172579 mRNA. Translation: AAO22238.1.
AY172580 mRNA. Translation: AAO22239.1.
CCDSiCCDS43514.1. [Q6H3X3-1]
RefSeqiNP_001001788.2. NM_001001788.3. [Q6H3X3-1]
UniGeneiHs.535023.
Hs.558792.

3D structure databases

ProteinModelPortaliQ6H3X3.
SMRiQ6H3X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6H3X3. 1 interactor.
STRINGi9606.ENSP00000356329.

PTM databases

iPTMnetiQ6H3X3.
PhosphoSitePlusiQ6H3X3.

Polymorphism and mutation databases

BioMutaiRAET1G.
DMDMi56749591.

Proteomic databases

MaxQBiQ6H3X3.
PaxDbiQ6H3X3.
PeptideAtlasiQ6H3X3.
PRIDEiQ6H3X3.
TopDownProteomicsiQ6H3X3-1. [Q6H3X3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367360; ENSP00000356329; ENSG00000203722. [Q6H3X3-1]
ENST00000367361; ENSP00000356330; ENSG00000203722. [Q6H3X3-2]
GeneIDi353091.
KEGGihsa:353091.
UCSCiuc010kii.1. human. [Q6H3X3-1]

Organism-specific databases

CTDi353091.
DisGeNETi353091.
GeneCardsiRAET1G.
H-InvDBHIX0025204.
HGNCiHGNC:16795. RAET1G.
HPAiHPA062673.
MIMi609244. gene.
neXtProtiNX_Q6H3X3.
OpenTargetsiENSG00000203722.
PharmGKBiPA134897742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4VC. Eukaryota.
ENOG41113ZC. LUCA.
GeneTreeiENSGT00390000003472.
HOGENOMiHOG000070028.
InParanoidiQ6H3X3.
KOiK07987.
OMAiQIAKRPL.
OrthoDBiEOG091G0I62.
PhylomeDBiQ6H3X3.
TreeFamiTF341724.

Enzyme and pathway databases

BioCyciZFISH:G66-33357-MONOMER.

Miscellaneous databases

GenomeRNAii353091.
PROiQ6H3X3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000203722.
ExpressionAtlasiQ6H3X3. baseline and differential.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF00129. MHC_I. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRET1G_HUMAN
AccessioniPrimary (citable) accession number: Q6H3X3
Secondary accession number(s): Q6H3X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.