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Protein

Putative DNA-directed RNA polymerase II subunit RPB2 homolog

Gene

FV3-062L

Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi823Magnesium; shared with DNA-directed RNA polymerase largest subunitBy similarity1
Metal bindingi1174ZincBy similarity1
Metal bindingi1177ZincBy similarity1
Metal bindingi1187ZincBy similarity1
Metal bindingi1190ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1174 – 1190C4-typeSequence analysisAdd BLAST17

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMagnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative DNA-directed RNA polymerase II subunit RPB2 homolog (EC:2.7.7.6)
Gene namesi
ORF Names:FV3-062L
OrganismiFrog virus 3 (isolate Goorha) (FV-3)
Taxonomic identifieri654924 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeAlphairidovirinaeRanavirus
Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
Dryophytes versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]
Proteomesi
  • UP000008770 Componenti: Genome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004105741 – 1221Putative DNA-directed RNA polymerase II subunit RPB2 homologAdd BLAST1221

Structurei

3D structure databases

ProteinModelPortaliQ6GZR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1174 – 1190C4-typeSequence analysisAdd BLAST17

Keywords - Domaini

Zinc-finger

Phylogenomic databases

KOiK03010.
OrthoDBiVOG0900000N.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 1 hit.
InterProiView protein in InterPro
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNAP_su2_dom.
IPR037033. DNA-dir_RNAP_su2_hyb_sf.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiView protein in Pfam
PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF00562. RNA_pol_Rpb2_6. 2 hits.
PF04560. RNA_pol_Rpb2_7. 1 hit.
PROSITEiView protein in PROSITE
PS01166. RNA_POL_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGMTTEGA SLTAAASSSA STWLTESTPS TPSSSGSSYP ALSTFSSCSN
60 70 80 90 100
SASSPDEADP MSEMSPKISV ASMILLKDME EFLHLYVSSA NMHPSNFVRH
110 120 130 140 150
HIESFDDMLW NEFPAMVARE KPVSVKGYRV KFGTVRYEPP CPDGKPWEKL
160 170 180 190 200
TPAMARRTDA TYHSAAVCDL TVTDPKGLET VYPRLELCKI PVMVGSAVCW
210 220 230 240 250
TRTEGSPLPG ECPSDPGGYF IIKGKERVVV PHIRPAYDQP CVYKNGDGWL
260 270 280 290 300
CEFRSVNRET RQTVLVQAKT DCRRKLEFSL PYIKQYVPVG LVFKALGKTA
310 320 330 340 350
REAVAMCGLG SFLGDEVSCR TVHHQSMAAL LMEQHASAPE DPVADLAKHV
360 370 380 390 400
PDGRSVYSKQ AEGAKQAKYA DRASVEEDRN AKGSKEDYVR HVLAGEIFLH
410 420 430 440 450
GGDAAEHLGW MVKRMADAAS GIGTCTDRDD LANKRVDATG PLIAFLLDGL
460 470 480 490 500
LKQYVKLFVK SAGCQKNLCP YTVLQNSMVM TNSLHMCFAT GNWTVKRLGP
510 520 530 540 550
PSYVRVGVSQ VLSNNNYGAR VSHLRRIMHA VSFRGKNIRM RQLHSSHYGF
560 570 580 590 600
LCPYETPEGE KVGIVLNMAE GAGFSLETPR EVVLATVRLG KGLPGFFEGA
610 620 630 640 650
PARLAWSGAA GSASVDVDGV LCGVTGDPVG FVREARLCLP GVSVVWKKVE
660 670 680 690 700
REIHLLGCQG RFVRRVLDPE GIRGSGYDSP PAPEERDIEM DPAPSSSPSD
710 720 730 740 750
SLPCPPGVYV CAQELSVCSL GDGEYADPPA SEILTDAMSS VIPFYDHTQS
760 770 780 790 800
PRNAYQSNMG KQAIGFPAVN CSDRYDATLH RLDYPQKSLV DSRSVKRLGF
810 820 830 840 850
DEMAHGALPV VAIMTAGGFN QEDSVVLNAS SLDRGLFSCV TYRTVSCADK
860 870 880 890 900
RRTKYDSEVV CLPDWGLRNR EWDYDLLGDD GVIDPSCAGA LARRVEGKRK
910 920 930 940 950
AAKRPAGQRT GGGPAGLCDA LWIPAGTVLV GKVSHSLGPG GNPMRRDVSL
960 970 980 990 1000
TVKQSEEGYL DRVTVDVDSD GKKLVKVRLR TPRHPEMGDK FASFTAQKGT
1010 1020 1030 1040 1050
CGAVLTQEDM PFDKDGVVPD LIINPHAFPS RMTVNYLLQM CFGTAACKLG
1060 1070 1080 1090 1100
KTYDATAFER EDVVRDIAEA AKEAGIDCWD SVLHSGSTGR RLPTKIFMAP
1110 1120 1130 1140 1150
CPYQRLKHMV SGKMHSRTHG PTDALTRQPV AGRSREGGIK IGEMEQWCKI
1160 1170 1180 1190 1200
SHGASESLKE SVYDMSDKYE VPVCKECGRI SDHFEYCRMC DATDMSLVKL
1210 1220
PYTTKILFQE LRSIGISIAF K
Length:1,221
Mass (Da):133,260
Last modified:July 19, 2004 - v1
Checksum:i8E96C8A2D671B948
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548484 Genomic DNA. Translation: AAT09722.1.
RefSeqiYP_031641.1. NC_005946.1.

Genome annotation databases

GeneIDi2947762.
KEGGivg:2947762.

Similar proteinsi

Entry informationi

Entry nameiRPB2_FRG3G
AccessioniPrimary (citable) accession number: Q6GZR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families