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Q6GZR2 (DUT_FRG3G) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Gene names
ORF Names:FV3-063R
OrganismFrog virus 3 (isolate Goorha) (FV-3) [Reference proteome]
Taxonomic identifier654924 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
Virus hostAmbystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Putative deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000410587

Regions

Region65 – 673Substrate binding By similarity
Region79 – 824Substrate binding By similarity
Region138 – 1392Substrate binding By similarity

Sites

Binding site901Substrate; via amide nitrogen and carbonyl oxygen By similarity

Amino acid modifications

Modified residue711N6-acetyllysine; by host By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GZR2 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 1E78DC1098330934

FASTA16417,435
        10         20         30         40         50         60 
MHGNSLQYVK LSEHASGLIR GSAGAAGYDL AAAHPVVVPS FGRALVKTDL AVKMPPGLYG 

        70         80         90        100        110        120 
RVAPRSGLAL KKFIDVGAGV VDPDYRGNLG VILFNFGCDP FRVKRGDRIA QLVLERYESP 

       130        140        150        160 
PILEVDSLDS TDRGDAGYGS TGVGNWHSAL WEGFSSGDLK ESFV 

« Hide

References

[1]"Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY548484 Genomic DNA. Translation: AAT09723.1.
RefSeqYP_031642.1. NC_005946.1.

3D structure databases

ProteinModelPortalQ6GZR2.
SMRQ6GZR2. Positions 6-142.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2947763.

Phylogenomic databases

ProtClustDBCLSP2512370.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_FRG3G
AccessionPrimary (citable) accession number: Q6GZR2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families