Q6GZR2 (DUT_FRG3G) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Gene names

ORF Names:

FV3-063R

Organism

Frog virus 3 (isolate Goorha) (FV-3) [Reference proteome]

Taxonomic identifier

654924 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Ranavirus › Frog virus 3

Virus host

Ambystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana pipiens (Northern leopard frog) [TaxID: 8404]
Rana sylvatica (Wood frog) [TaxID: 45438]

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 164	164	Putative deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000410587
Regions
	Region	65 – 67	3	Substrate binding By similarity
	Region	79 – 82	4	Substrate binding By similarity
	Region	138 – 139	2	Substrate binding By similarity
Sites
	Binding site	90	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity
Amino acid modifications
	Modified residue	71	1	N6-acetyllysine; by host By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GZR2 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1E78DC1098330934	FASTA	164	17,435
	10 20 30 40 50 60 MHGNSLQYVK LSEHASGLIR GSAGAAGYDL AAAHPVVVPS FGRALVKTDL AVKMPPGLYG 70 80 90 100 110 120 RVAPRSGLAL KKFIDVGAGV VDPDYRGNLG VILFNFGCDP FRVKRGDRIA QLVLERYESP 130 140 150 160 PILEVDSLDS TDRGDAGYGS TGVGNWHSAL WEGFSSGDLK ESFV

References

[1]	"Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)." Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K. Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY548484 Genomic DNA. Translation: AAT09723.1.
RefSeq	YP_031642.1. NC_005946.1.
3D structure databases
ProteinModelPortal	Q6GZR2.
SMR	Q6GZR2. Positions 6-142.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2947763.
Phylogenomic databases
ProtClustDB	CLSP2512370.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DUT_FRG3G

Accession

Primary (citable) accession number: Q6GZR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	July 19, 2004
Last modified:	October 3, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program