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Q6GZR2

- DUT_FRG3G

UniProt

Q6GZR2 - DUT_FRG3G

Protein

Putative deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

FV3-063R

Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901Substrate; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Gene namesi
    ORF Names:FV3-063R
    OrganismiFrog virus 3 (isolate Goorha) (FV-3)
    Taxonomic identifieri654924 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
    Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
    Hyla versicolor (chameleon treefrog) [TaxID: 30343]
    Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
    Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
    Rana sylvatica (Wood frog) [TaxID: 45438]
    ProteomesiUP000008770: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Putative deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000410587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711N6-acetyllysine; by hostBy similarity

    Keywords - PTMi

    Acetylation

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GZR2.
    SMRiQ6GZR2. Positions 6-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni65 – 673Substrate bindingBy similarity
    Regioni79 – 824Substrate bindingBy similarity
    Regioni138 – 1392Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GZR2-1 [UniParc]FASTAAdd to Basket

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    MHGNSLQYVK LSEHASGLIR GSAGAAGYDL AAAHPVVVPS FGRALVKTDL    50
    AVKMPPGLYG RVAPRSGLAL KKFIDVGAGV VDPDYRGNLG VILFNFGCDP 100
    FRVKRGDRIA QLVLERYESP PILEVDSLDS TDRGDAGYGS TGVGNWHSAL 150
    WEGFSSGDLK ESFV 164
    Length:164
    Mass (Da):17,435
    Last modified:July 19, 2004 - v1
    Checksum:i1E78DC1098330934
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548484 Genomic DNA. Translation: AAT09723.1.
    RefSeqiYP_031642.1. NC_005946.1.

    Genome annotation databases

    GeneIDi2947763.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548484 Genomic DNA. Translation: AAT09723.1 .
    RefSeqi YP_031642.1. NC_005946.1.

    3D structure databases

    ProteinModelPortali Q6GZR2.
    SMRi Q6GZR2. Positions 6-142.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2947763.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
      Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
      Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_FRG3G
    AccessioniPrimary (citable) accession number: Q6GZR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3