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Q6GZQ8

- RIR2_FRG3G

UniProt

Q6GZQ8 - RIR2_FRG3G

Protein

Putative ribonucleoside-diphosphate reductase small subunit 067L

Gene

FV3-067L

Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi131 – 1311Iron 1By similarity
    Metal bindingi162 – 1621Iron 1By similarity
    Metal bindingi162 – 1621Iron 2By similarity
    Metal bindingi165 – 1651Iron 1By similarity
    Active sitei169 – 1691By similarity
    Metal bindingi221 – 2211Iron 2By similarity
    Metal bindingi255 – 2551Iron 2By similarity
    Metal bindingi258 – 2581Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ribonucleoside-diphosphate reductase small subunit 067L (EC:1.17.4.1)
    Gene namesi
    ORF Names:FV3-067L
    OrganismiFrog virus 3 (isolate Goorha) (FV-3)
    Taxonomic identifieri654924 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
    Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
    Hyla versicolor (chameleon treefrog) [TaxID: 30343]
    Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
    Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
    Rana sylvatica (Wood frog) [TaxID: 45438]
    ProteomesiUP000008770: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Putative ribonucleoside-diphosphate reductase small subunit 067LPRO_0000410579Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GZQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GZQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPHVTIVEK PGCGNCVTLK RALKEKSVPH TVMPYVPGVP GSYPIATVGG    50
    QRVGYREITK ALAMDMFTTS KCFKPFRYNW AEDIRTKHEK VHWVETEINL 100
    RDDVTDWKSG VMTPGEKAFV SCVLRLFTQL DVEVGALYLD HLTQVFRCNE 150
    IRNMLTSFAC REAIHQKAYS LLNDTLGMPD CEYQAFADYG EMTDKLDFMR 200
    EMDCSTLPGL ARSLLRAVLN EGVSLFAAFV MLLTFQRSGK MKGMGKVVEW 250
    SVRDENIHVE GVSKLFETLN SEYPWVVTKD LIELFKEDAE RVAELEEAFV 300
    DLAFQECGPV CGLEPKQVKD YVLYVINLRA ANMGLPKLIE RAPEACPIPW 350
    VKWLIDGADL TNFFENHVTE YETGGLTGSW SYEPLDI 387
    Length:387
    Mass (Da):43,890
    Last modified:July 19, 2004 - v1
    Checksum:i4E4C594687191C0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548484 Genomic DNA. Translation: AAT09727.1.
    RefSeqiYP_031646.1. NC_005946.1.

    Genome annotation databases

    GeneIDi2947767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY548484 Genomic DNA. Translation: AAT09727.1 .
    RefSeqi YP_031646.1. NC_005946.1.

    3D structure databases

    ProteinModelPortali Q6GZQ8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2947767.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
      Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
      Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR2_FRG3G
    AccessioniPrimary (citable) accession number: Q6GZQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3