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Q6GZQ8

- RIR2_FRG3G

UniProt

Q6GZQ8 - RIR2_FRG3G

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Protein

Putative ribonucleoside-diphosphate reductase small subunit 067L

Gene

FV3-067L

Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi131 – 1311Iron 1By similarity
Metal bindingi162 – 1621Iron 1By similarity
Metal bindingi162 – 1621Iron 2By similarity
Metal bindingi165 – 1651Iron 1By similarity
Active sitei169 – 1691By similarity
Metal bindingi221 – 2211Iron 2By similarity
Metal bindingi255 – 2551Iron 2By similarity
Metal bindingi258 – 2581Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribonucleoside-diphosphate reductase small subunit 067L (EC:1.17.4.1)
Gene namesi
ORF Names:FV3-067L
OrganismiFrog virus 3 (isolate Goorha) (FV-3)
Taxonomic identifieri654924 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]
ProteomesiUP000008770: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Putative ribonucleoside-diphosphate reductase small subunit 067LPRO_0000410579Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GZQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GZQ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPHVTIVEK PGCGNCVTLK RALKEKSVPH TVMPYVPGVP GSYPIATVGG
60 70 80 90 100
QRVGYREITK ALAMDMFTTS KCFKPFRYNW AEDIRTKHEK VHWVETEINL
110 120 130 140 150
RDDVTDWKSG VMTPGEKAFV SCVLRLFTQL DVEVGALYLD HLTQVFRCNE
160 170 180 190 200
IRNMLTSFAC REAIHQKAYS LLNDTLGMPD CEYQAFADYG EMTDKLDFMR
210 220 230 240 250
EMDCSTLPGL ARSLLRAVLN EGVSLFAAFV MLLTFQRSGK MKGMGKVVEW
260 270 280 290 300
SVRDENIHVE GVSKLFETLN SEYPWVVTKD LIELFKEDAE RVAELEEAFV
310 320 330 340 350
DLAFQECGPV CGLEPKQVKD YVLYVINLRA ANMGLPKLIE RAPEACPIPW
360 370 380
VKWLIDGADL TNFFENHVTE YETGGLTGSW SYEPLDI
Length:387
Mass (Da):43,890
Last modified:July 19, 2004 - v1
Checksum:i4E4C594687191C0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548484 Genomic DNA. Translation: AAT09727.1.
RefSeqiYP_031646.1. NC_005946.1.

Genome annotation databases

GeneIDi2947767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548484 Genomic DNA. Translation: AAT09727.1 .
RefSeqi YP_031646.1. NC_005946.1.

3D structure databases

ProteinModelPortali Q6GZQ8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2947767.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
    Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
    Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_FRG3G
AccessioniPrimary (citable) accession number: Q6GZQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3