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Protein

Putative ribonucleoside-diphosphate reductase small subunit 067L

Gene

FV3-067L

Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Iron 1By similarity1
Metal bindingi162Iron 1By similarity1
Metal bindingi162Iron 2By similarity1
Metal bindingi165Iron 1By similarity1
Active sitei169By similarity1
Metal bindingi221Iron 2By similarity1
Metal bindingi255Iron 2By similarity1
Metal bindingi258Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribonucleoside-diphosphate reductase small subunit 067L (EC:1.17.4.1)
Gene namesi
ORF Names:FV3-067L
OrganismiFrog virus 3 (isolate Goorha) (FV-3)
Taxonomic identifieri654924 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeAlphairidovirinaeRanavirus
Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
Dryophytes versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]
Proteomesi
  • UP000008770 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004105791 – 387Putative ribonucleoside-diphosphate reductase small subunit 067LAdd BLAST387

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GZQ8.
SMRiQ6GZQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000AL.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
InterProiView protein in InterPro
IPR009078. Ferritin-like_SF.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiView protein in Pfam
PF00268. Ribonuc_red_sm. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GZQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPHVTIVEK PGCGNCVTLK RALKEKSVPH TVMPYVPGVP GSYPIATVGG
60 70 80 90 100
QRVGYREITK ALAMDMFTTS KCFKPFRYNW AEDIRTKHEK VHWVETEINL
110 120 130 140 150
RDDVTDWKSG VMTPGEKAFV SCVLRLFTQL DVEVGALYLD HLTQVFRCNE
160 170 180 190 200
IRNMLTSFAC REAIHQKAYS LLNDTLGMPD CEYQAFADYG EMTDKLDFMR
210 220 230 240 250
EMDCSTLPGL ARSLLRAVLN EGVSLFAAFV MLLTFQRSGK MKGMGKVVEW
260 270 280 290 300
SVRDENIHVE GVSKLFETLN SEYPWVVTKD LIELFKEDAE RVAELEEAFV
310 320 330 340 350
DLAFQECGPV CGLEPKQVKD YVLYVINLRA ANMGLPKLIE RAPEACPIPW
360 370 380
VKWLIDGADL TNFFENHVTE YETGGLTGSW SYEPLDI
Length:387
Mass (Da):43,890
Last modified:July 19, 2004 - v1
Checksum:i4E4C594687191C0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548484 Genomic DNA. Translation: AAT09727.1.
RefSeqiYP_031646.1. NC_005946.1.

Genome annotation databases

GeneIDi2947767.
KEGGivg:2947767.

Similar proteinsi

Entry informationi

Entry nameiRIR2_FRG3G
AccessioniPrimary (citable) accession number: Q6GZQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: September 27, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families