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Q6GZQ8 (RIR2_FRG3G) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ribonucleoside-diphosphate reductase small subunit 067L

EC=1.17.4.1
Gene names
ORF Names:FV3-067L
OrganismFrog virus 3 (isolate Goorha) (FV-3) [Reference proteome]
Taxonomic identifier654924 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
Virus hostAmbystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Putative ribonucleoside-diphosphate reductase small subunit 067L
PRO_0000410579

Sites

Active site1691 By similarity
Metal binding1311Iron 1 By similarity
Metal binding1621Iron 1 By similarity
Metal binding1621Iron 2 By similarity
Metal binding1651Iron 1 By similarity
Metal binding2211Iron 2 By similarity
Metal binding2551Iron 2 By similarity
Metal binding2581Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GZQ8 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 4E4C594687191C0D

FASTA38743,890
        10         20         30         40         50         60 
MFPHVTIVEK PGCGNCVTLK RALKEKSVPH TVMPYVPGVP GSYPIATVGG QRVGYREITK 

        70         80         90        100        110        120 
ALAMDMFTTS KCFKPFRYNW AEDIRTKHEK VHWVETEINL RDDVTDWKSG VMTPGEKAFV 

       130        140        150        160        170        180 
SCVLRLFTQL DVEVGALYLD HLTQVFRCNE IRNMLTSFAC REAIHQKAYS LLNDTLGMPD 

       190        200        210        220        230        240 
CEYQAFADYG EMTDKLDFMR EMDCSTLPGL ARSLLRAVLN EGVSLFAAFV MLLTFQRSGK 

       250        260        270        280        290        300 
MKGMGKVVEW SVRDENIHVE GVSKLFETLN SEYPWVVTKD LIELFKEDAE RVAELEEAFV 

       310        320        330        340        350        360 
DLAFQECGPV CGLEPKQVKD YVLYVINLRA ANMGLPKLIE RAPEACPIPW VKWLIDGADL 

       370        380 
TNFFENHVTE YETGGLTGSW SYEPLDI 

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References

[1]"Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY548484 Genomic DNA. Translation: AAT09727.1.
RefSeqYP_031646.1. NC_005946.1.

3D structure databases

ProteinModelPortalQ6GZQ8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2947767.

Phylogenomic databases

ProtClustDBCLSP2511500.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIR2_FRG3G
AccessionPrimary (citable) accession number: Q6GZQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways