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Q6GZP5 (RNC_FRG3G) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
ORF Names:FV3-080L
OrganismFrog virus 3 (isolate Goorha) (FV-3) [Reference proteome]
Taxonomic identifier654924 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
Virus hostAmbystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA By similarity.

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester.

Sequence similarities

Belongs to the IIV-6 142R family.

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonuclease III activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Putative ribonuclease 3
PRO_0000410590

Regions

Domain10 – 136127RNase III

Sequences

Sequence LengthMass (Da)Tools
Q6GZP5 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 86638E1130E44E6A

FASTA37140,362
        10         20         30         40         50         60 
MEGWLGNLLA KSVKDKYIPV IVGRRDLWNK VFTPKSVNPD DNYEALEIVG DGVASYFFPS 

        70         80         90        100        110        120 
YFLKRFPQLN SPKGVKTVAR LKIYYGSKKS FSSIADSLGF WKFIRSGPVP VNPSTRESLL 

       130        140        150        160        170        180 
EDTFEAFLGA VCMAVDDEYS IDGLGAVVAY KIMADIFDDM DISLEYTALF DTVTRLKELM 

       190        200        210        220        230        240 
DVKKDVLGGD AVYNHRGDTT VITLKGRVIG KATGAIKRDR AKEAAGQALD LLRREGHFRE 

       250        260        270        280        290        300 
HDDDAVVKVA KGPAGDGLVV AQSALGGFTV FGAESGVVEG SGGTVAQALS RVVGTKRPSA 

       310        320        330        340        350        360 
VEVAGGDYKS LLKEYLESVG ETDSVNYIHE GVTVTMTRKG KPVATANHLV KKVREQLASR 

       370 
DYYRTVHAKG V 

« Hide

References

[1]"Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY548484 Genomic DNA. Translation: AAT09740.1.
RefSeqYP_031659.1. NC_005946.1.

3D structure databases

ProteinModelPortalQ6GZP5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2947799.

Phylogenomic databases

ProtClustDBCLSP2511515.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
InterProIPR000999. RNase_III_dom.
[Graphical view]
PfamPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
PROSITEPS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_FRG3G
AccessionPrimary (citable) accession number: Q6GZP5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families