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Protein

Putative ribonuclease 3

Gene

FV3-080L

Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Digests double-stranded RNA.By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

GO - Molecular functioni

  1. ribonuclease III activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribonuclease 3 (EC:3.1.26.3)
Alternative name(s):
Ribonuclease III
Short name:
RNase III
Gene namesi
ORF Names:FV3-080L
OrganismiFrog virus 3 (isolate Goorha) (FV-3)
Taxonomic identifieri654924 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]
ProteomesiUP000008770 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Putative ribonuclease 3PRO_0000410590Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6GZP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 136127RNase IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the IIV-6 142R family.Curated
Contains 1 RNase III domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK03685.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
InterProiIPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GZP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGWLGNLLA KSVKDKYIPV IVGRRDLWNK VFTPKSVNPD DNYEALEIVG
60 70 80 90 100
DGVASYFFPS YFLKRFPQLN SPKGVKTVAR LKIYYGSKKS FSSIADSLGF
110 120 130 140 150
WKFIRSGPVP VNPSTRESLL EDTFEAFLGA VCMAVDDEYS IDGLGAVVAY
160 170 180 190 200
KIMADIFDDM DISLEYTALF DTVTRLKELM DVKKDVLGGD AVYNHRGDTT
210 220 230 240 250
VITLKGRVIG KATGAIKRDR AKEAAGQALD LLRREGHFRE HDDDAVVKVA
260 270 280 290 300
KGPAGDGLVV AQSALGGFTV FGAESGVVEG SGGTVAQALS RVVGTKRPSA
310 320 330 340 350
VEVAGGDYKS LLKEYLESVG ETDSVNYIHE GVTVTMTRKG KPVATANHLV
360 370
KKVREQLASR DYYRTVHAKG V
Length:371
Mass (Da):40,362
Last modified:July 19, 2004 - v1
Checksum:i86638E1130E44E6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548484 Genomic DNA. Translation: AAT09740.1.
RefSeqiYP_031659.1. NC_005946.1.

Genome annotation databases

GeneIDi2947799.
KEGGivg:2947799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548484 Genomic DNA. Translation: AAT09740.1.
RefSeqiYP_031659.1. NC_005946.1.

3D structure databases

ProteinModelPortaliQ6GZP5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2947799.
KEGGivg:2947799.

Phylogenomic databases

KOiK03685.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
InterProiIPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
    Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
    Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRNC_FRG3G
AccessioniPrimary (citable) accession number: Q6GZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: July 19, 2004
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.