Q6GZP5 (RNC_FRG3G) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

ORF Names:

FV3-080L

Organism

Frog virus 3 (isolate Goorha) (FV-3) [Reference proteome]

Taxonomic identifier

654924 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Ranavirus › Frog virus 3

Virus host

Ambystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana pipiens (Northern leopard frog) [TaxID: 8404]
Rana sylvatica (Wood frog) [TaxID: 45438]

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA By similarity.
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester.
Sequence similarities	Belongs to the IIV-6 142R family. Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Putative ribonuclease 3		PRO_0000410590
Regions
	Domain	10 – 136	127	RNase III

Sequences

	Sequence		Length	Mass (Da)
	Q6GZP5 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 86638E1130E44E6A	FASTA	371	40,362
	10 20 30 40 50 60 MEGWLGNLLA KSVKDKYIPV IVGRRDLWNK VFTPKSVNPD DNYEALEIVG DGVASYFFPS 70 80 90 100 110 120 YFLKRFPQLN SPKGVKTVAR LKIYYGSKKS FSSIADSLGF WKFIRSGPVP VNPSTRESLL 130 140 150 160 170 180 EDTFEAFLGA VCMAVDDEYS IDGLGAVVAY KIMADIFDDM DISLEYTALF DTVTRLKELM 190 200 210 220 230 240 DVKKDVLGGD AVYNHRGDTT VITLKGRVIG KATGAIKRDR AKEAAGQALD LLRREGHFRE 250 260 270 280 290 300 HDDDAVVKVA KGPAGDGLVV AQSALGGFTV FGAESGVVEG SGGTVAQALS RVVGTKRPSA 310 320 330 340 350 360 VEVAGGDYKS LLKEYLESVG ETDSVNYIHE GVTVTMTRKG KPVATANHLV KKVREQLASR 370 DYYRTVHAKG V

References

[1]	"Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)." Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K. Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY548484 Genomic DNA. Translation: AAT09740.1.
RefSeq	YP_031659.1. NC_005946.1.
3D structure databases
ProteinModelPortal	Q6GZP5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2947799.
Phylogenomic databases
ProtClustDB	CLSP2511515.
Family and domain databases
Gene3D	1.10.1520.10. 1 hit.
InterPro	IPR000999. RNase_III_dom. [Graphical view]
Pfam	PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
PROSITE	PS00517. RNASE_3_1. False negative. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_FRG3G

Accession

Primary (citable) accession number: Q6GZP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	July 19, 2004
Last modified:	March 6, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program