Ralgapa1

Functionⁱ

Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12.By similarity

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB
protein heterodimerization activity Source: MGI

Complete GO annotation...

GO - Biological processⁱ

activation of GTPase activity Source: UniProtKB
regulation of small GTPase mediated signal transduction Source: InterPro
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 12200424

Complete GO annotation...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ral GTPase-activating protein subunit alpha-1 Alternative name(s): GAP-related-interacting partner to E12 Short name: GRIPE GTPase-activating RapGAP domain-like 1 Tuberin-like protein 1 p240
Gene namesⁱ	Name:Ralgapa1 Synonyms:Garnl1, Kiaa0884, Tulip1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:1931050. Ralgapa1.

Subcellular locationⁱ

Note:

Translocated to the nucleus, when associated with TCF3/E12.

GO - Cellular componentⁱ

cytoplasm
Source: MGI
Inferred from direct assayⁱ
- 12200424
nucleus
Source: MGI
Inferred from direct assayⁱ
- 12200424

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056754	1 – 2035	Ral GTPase-activating protein subunit alpha-1Add BLAST		2035

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	710	PhosphoserineBy similarity	1
Modified residueⁱ	720	PhosphoserineBy similarity	1
Modified residueⁱ	753	PhosphothreonineCombined sources	1
Modified residueⁱ	772	PhosphoserineCombined sources	1
Modified residueⁱ	777	PhosphothreonineBy similarity	1
Modified residueⁱ	796	PhosphoserineBy similarity	1
Modified residueⁱ	859	PhosphoserineCombined sources	1
Modified residueⁱ	860	PhosphoserineCombined sources	1
Modified residueⁱ	863	PhosphoserineCombined sources	1
Modified residueⁱ	985	PhosphoserineBy similarity	1
Modified residueⁱ	989	PhosphoserineBy similarity	1
Modified residueⁱ	993	PhosphoserineBy similarity	1
Modified residueⁱ	999	PhosphoserineBy similarity	1
Modified residueⁱ	1001	PhosphothreonineCombined sources	1
Modified residueⁱ	1003	PhosphoserineBy similarity	1
Modified residueⁱ	1477	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6GYP7.
PeptideAtlas More...PeptideAtlasⁱ	Q6GYP7.
PRIDEⁱ	Q6GYP7.

PTM databases

iPTMnetⁱ	Q6GYP7.
PhosphoSitePlusⁱ	Q6GYP7.

Expressionⁱ

Tissue specificityⁱ

Expressed during embryogenesis. Expressed in the adult brain, particularly in neurons of the cortex and hippocampus.1 Publication

Developmental stageⁱ

Expression decreased during development, but persists in the adult brain.

Gene expression databases

Bgeeⁱ	ENSMUSG00000021027.
CleanExⁱ	MM_GARNL1.
Genevisibleⁱ	Q6GYP7. MM.

Interactionⁱ

Subunit structureⁱ

Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity (By similarity). Interacts with the HLH region of TCF3/isoform E12.By similarity1 Publication

GO - Molecular functionⁱ

protein heterodimerization activity Source: MGI

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	208171. 1 interactor.
IntActⁱ	Q6GYP7. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4096796.
STRINGⁱ	10090.ENSMUSP00000082503.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6GYP7.
SMRⁱ	Q6GYP7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1795 – 2003	Rap-GAPPROSITE-ProRule annotationAdd BLAST		209

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1326 – 2035	Minimal domain that binds to TCF3/E12Add BLAST		710

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1713 – 1748	Sequence analysisAdd BLAST		36

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	379 – 382	Poly-Ser		4

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3686. Eukaryota. ENOG410XTIX. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119182.
HOVERGENⁱ	HBG051842.
InParanoidⁱ	Q6GYP7.
OMAⁱ	CENHDNH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G005P.
PhylomeDBⁱ	Q6GYP7.
TreeFamⁱ	TF324484.

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024. ARM-type_fold. IPR000331. Rap_GAP_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02145. Rap_GAP. 1 hit.
SUPFAMⁱ	SSF111347. SSF111347. 1 hit. SSF48371. SSF48371. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50085. RAPGAP. 1 hit.

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6GYP7-1) [UniParc]FASTA Add to basket

Also known as: 3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH 
        60         70         80         90        100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH 
       110        120        130        140        150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM 
       160        170        180        190        200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD 
       210        220        230        240        250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP 
       260        270        280        290        300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 
       310        320        330        340        350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK 
       360        370        380        390        400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV 
       410        420        430        440        450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ 
       460        470        480        490        500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK 
       510        520        530        540        550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL 
       560        570        580        590        600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 
       610        620        630        640        650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS 
       660        670        680        690        700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK 
       710        720        730        740        750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR 
       760        770        780        790        800
QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI 
       810        820        830        840        850
LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE FIAERLRSGN 
       860        870        880        890        900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 
       910        920        930        940        950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST 
       960        970        980        990       1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ 
      1010       1020       1030       1040       1050
TPSPSTLSRA HIEQKDLQLD EKLHHSVLQT PDDLEISEFP SECCSVMAGG 
      1060       1070       1080       1090       1100
TLTGWHADVA TVMWRRMLGI LGDVNAIMDP EIHAQVFDYL CELWQNLAKI 
      1110       1120       1130       1140       1150
RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY KQGKLHAYKL 
      1160       1170       1180       1190       1200
ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 
      1210       1220       1230       1240       1250
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL 
      1260       1270       1280       1290       1300
PALHPNIPDI AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI 
      1310       1320       1330       1340       1350
CEELVHESHH PQIKEALNVI CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ 
      1360       1370       1380       1390       1400
IHQPQSPLKI IQILIATITH LLPSTEASSY EMDKRLVVSL LLCLLDWIMA 
      1410       1420       1430       1440       1450
LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ SFSNPKYFPI 
      1460       1470       1480       1490       1500
SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 
      1510       1520       1530       1540       1550
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL 
      1560       1570       1580       1590       1600
FESPNIQFFV LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD 
      1610       1620       1630       1640       1650
LSGKYSWDSA ILYGPPIVSG LPEPTSFILS MSDQEKPEEP PTSNECLEDI 
      1660       1670       1680       1690       1700
AVKDGLSLQL RRFRETVPTW STIREEEDVL DELLQYLGTT SPECLQRTGI 
      1710       1720       1730       1740       1750
SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN DLNMKASEQD 
      1760       1770       1780       1790       1800
EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 
      1810       1820       1830       1840       1850
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH 
      1860       1870       1880       1890       1900
CGFMGGLQKN RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL 
      1910       1920       1930       1940       1950
GNDEVHIVWS EHTRDYRRGI IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV 
      1960       1970       1980       1990       2000
PFFGPLFDGA IVNGKVLPIM VRSTAINASR ALKSLIPLYQ NFYEERARYL 
      2010       2020       2030 
QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADADH

Length:2,035

Mass (Da):229,389

Last modified:July 19, 2004 - v1

Checksum:ⁱ1F4C3E24022EBB54

GO

Isoform 2 (identifier: Q6GYP7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2034-2035: DH → VGSYPEIPPSDAAPAAQVDGADLASPMSPRTSKSR

« Hide

        10         20         30         40         50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH 
        60         70         80         90        100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH 
       110        120        130        140        150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM 
       160        170        180        190        200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD 
       210        220        230        240        250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP 
       260        270        280        290        300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 
       310        320        330        340        350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK 
       360        370        380        390        400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV 
       410        420        430        440        450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ 
       460        470        480        490        500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK 
       510        520        530        540        550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL 
       560        570        580        590        600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 
       610        620        630        640        650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS 
       660        670        680        690        700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK 
       710        720        730        740        750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR 
       760        770        780        790        800
QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI 
       810        820        830        840        850
LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE FIAERLRSGN 
       860        870        880        890        900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 
       910        920        930        940        950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST 
       960        970        980        990       1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ 
      1010       1020       1030       1040       1050
TPSPSTLSRA HIEQKDLQLD EKLHHSVLQT PDDLEISEFP SECCSVMAGG 
      1060       1070       1080       1090       1100
TLTGWHADVA TVMWRRMLGI LGDVNAIMDP EIHAQVFDYL CELWQNLAKI 
      1110       1120       1130       1140       1150
RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY KQGKLHAYKL 
      1160       1170       1180       1190       1200
ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 
      1210       1220       1230       1240       1250
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL 
      1260       1270       1280       1290       1300
PALHPNIPDI AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI 
      1310       1320       1330       1340       1350
CEELVHESHH PQIKEALNVI CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ 
      1360       1370       1380       1390       1400
IHQPQSPLKI IQILIATITH LLPSTEASSY EMDKRLVVSL LLCLLDWIMA 
      1410       1420       1430       1440       1450
LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ SFSNPKYFPI 
      1460       1470       1480       1490       1500
SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 
      1510       1520       1530       1540       1550
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL 
      1560       1570       1580       1590       1600
FESPNIQFFV LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD 
      1610       1620       1630       1640       1650
LSGKYSWDSA ILYGPPIVSG LPEPTSFILS MSDQEKPEEP PTSNECLEDI 
      1660       1670       1680       1690       1700
AVKDGLSLQL RRFRETVPTW STIREEEDVL DELLQYLGTT SPECLQRTGI 
      1710       1720       1730       1740       1750
SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN DLNMKASEQD 
      1760       1770       1780       1790       1800
EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 
      1810       1820       1830       1840       1850
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH 
      1860       1870       1880       1890       1900
CGFMGGLQKN RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL 
      1910       1920       1930       1940       1950
GNDEVHIVWS EHTRDYRRGI IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV 
      1960       1970       1980       1990       2000
PFFGPLFDGA IVNGKVLPIM VRSTAINASR ALKSLIPLYQ NFYEERARYL 
      2010       2020       2030       2040       2050
QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADAVGSYPEI PPSDAAPAAQ 
      2060 
VDGADLASPM SPRTSKSR

Show »

Length:2,068

Mass (Da):232,646

Checksum:ⁱCD55170FA5FBCF6B

GO

Isoform 4 (identifier: Q6GYP7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1298: Missing.
1299-1304: WICEEL → MMRFVE

« Hide

        10         20         30         40         50
MMRFVEVHES HHPQIKEALN VICVSLKFTN KTVAHVACNM LHMLVHYVPR 
        60         70         80         90        100
LQIHQPQSPL KIIQILIATI THLLPSTEAS SYEMDKRLVV SLLLCLLDWI 
       110        120        130        140        150
MALPLKTLLQ PVHATGAEND KTEKSVLNCI YKVLHGCVYG AQSFSNPKYF 
       160        170        180        190        200
PISLSDLASV DYDPFMHLES LKEPEPLHSP DSERSSKLQP VTEVKTQMQQ 
       210        220        230        240        250
GLISIAARTV ITHLVNHLGH YPMSGGPAML TSQVCENHDN HYSESTELSP 
       260        270        280        290        300
ELFESPNIQF FVLNNTTLVS CIQIRSEESM PGGGLAAGLV SANSNVRIIV 
       310        320        330        340        350
RDLSGKYSWD SAILYGPPIV SGLPEPTSFI LSMSDQEKPE EPPTSNECLE 
       360        370        380        390        400
DIAVKDGLSL QLRRFRETVP TWSTIREEED VLDELLQYLG TTSPECLQRT 
       410        420        430        440        450
GISLNVPAPQ PLCISEKQEN DVINAILKQY TEEKEFVEKH FNDLNMKASE 
       460        470        480        490        500
QDEPTPQKPQ SAFYYCRLLL SILGMNSWDK RRSFHLLKKN EKLLRELRNL 
       510        520        530        540        550
DSRQCRETHK IAVFYVAEGQ EDKYSILTNI GGSQAYEDFV AGLGWEVNLT 
       560        570        580        590        600
NHCGFMGGLQ KNRSTGLTTP YFATSTVEVI FHVSTRMPSD SDDSLTKKLR 
       610        620        630        640        650
HLGNDEVHIV WSEHTRDYRR GIIPTEFGDV LIVIYPMKNH MFSIQIMKKP 
       660        670        680        690        700
EVPFFGPLFD GAIVNGKVLP IMVRSTAINA SRALKSLIPL YQNFYEERAR 
       710        720        730 
YLQTIVQHHL EPTTFEDFAA QVFSPAPYHH FPADADH

Note: No experimental confirmation available.

Show »

Length:737

Mass (Da):83,311

Checksum:ⁱ3D72CD7AA1E1F7D4

GO

Isoform 5 (identifier: Q6GYP7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1035-1037: EIS → GNA
1038-2035: Missing.

« Hide

        10         20         30         40         50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH 
        60         70         80         90        100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH 
       110        120        130        140        150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM 
       160        170        180        190        200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD 
       210        220        230        240        250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP 
       260        270        280        290        300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 
       310        320        330        340        350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK 
       360        370        380        390        400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV 
       410        420        430        440        450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ 
       460        470        480        490        500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK 
       510        520        530        540        550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL 
       560        570        580        590        600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 
       610        620        630        640        650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS 
       660        670        680        690        700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK 
       710        720        730        740        750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR 
       760        770        780        790        800
QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI 
       810        820        830        840        850
LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE FIAERLRSGN 
       860        870        880        890        900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 
       910        920        930        940        950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST 
       960        970        980        990       1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ 
      1010       1020       1030 
TPSPSTLSRA HIEQKDLQLD EKLHHSVLQT PDDLGNA

Show »

Length:1,037

Mass (Da):117,170

Checksum:ⁱ23D34AB339388DC0

GO

Isoform 6 (identifier: Q6GYP7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1337: Missing.
     1897-1904: LRHLGNDE → VSAEGKHF
     1905-2035: Missing.

« Hide

        10         20         30         40         50
MLHMLVHYVP RLQIHQPQSP LKIIQILIAT ITHLLPSTEA SSYEMDKRLV 
        60         70         80         90        100
VSLLLCLLDW IMALPLKTLL QPVHATGAEN DKTEKSVLNC IYKVLHGCVY 
       110        120        130        140        150
GAQSFSNPKY FPISLSDLAS VDYDPFMHLE SLKEPEPLHS PDSERSSKLQ 
       160        170        180        190        200
PVTEVKTQMQ QGLISIAART VITHLVNHLG HYPMSGGPAM LTSQVCENHD 
       210        220        230        240        250
NHYSESTELS PELFESPNIQ FFVLNNTTLV SCIQIRSEES MPGGGLAAGL 
       260        270        280        290        300
VSANSNVRII VRDLSGKYSW DSAILYGPPI VSGLPEPTSF ILSMSDQEKP 
       310        320        330        340        350
EEPPTSNECL EDIAVKDGLS LQLRRFRETV PTWSTIREEE DVLDELLQYL 
       360        370        380        390        400
GTTSPECLQR TGISLNVPAP QPLCISEKQE NDVINAILKQ YTEEKEFVEK 
       410        420        430        440        450
HFNDLNMKAS EQDEPTPQKP QSAFYYCRLL LSILGMNSWD KRRSFHLLKK 
       460        470        480        490        500
NEKLLRELRN LDSRQCRETH KIAVFYVAEG QEDKYSILTN IGGSQAYEDF 
       510        520        530        540        550
VAGLGWEVNL TNHCGFMGGL QKNRSTGLTT PYFATSTVEV IFHVSTRMPS 
       560 
DSDDSLTKKV SAEGKHF

Note: No experimental confirmation available.

Show »

Length:567

Mass (Da):63,656

Checksum:ⁱ0B413D16DC68FE68

GO

Isoform 1S (identifier: Q6GYP7-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-555: Missing.

« Hide

        10         20         30         40         50
MCKRILNIYR YMVVQVSMDK KTWEQMLLVL LRVTESVLKM SSQAFLQFQG 
        60         70         80         90        100
KKSMTLAGRL AGPLFQTLIV AWIKANLNVY ISRELWDDLL SVLSSLTYWE 
       110        120        130        140        150
ELATEWSLTM ETLTKVLARN LYSLDLSDLP LDKLSEQKQK KHKGKGVGHE 
       160        170        180        190        200
FQKVSVDKSF SRGWSRDQPG QAPMRQRSAT TTGSPGTEKA RSIVRQKTVD 
       210        220        230        240        250
IDDAQILPRS TRVRHFSQSE DTGNEVFGAL HEEQPLPRSS STSDILEPFT 
       260        270        280        290        300
VERAKVNKED TSPKLPPLNS ETGGNSANVP DLMDEFIAER LRSGNASTMT 
       310        320        330        340        350
RRGSSPGSLE IPKDLPDILN KQNQMRPVDD PGVPSEWTSP ASAGSSDLMS 
       360        370        380        390        400
SDSHSDSFSA FQCEGRKFDN FGFGTDIGIP SSADVDLGSG HHQSTEEQEV 
       410        420        430        440        450
ASLTTLHLDS ETSSLNQQAF SAEVATVTGS ESASPVHSAL GSRSQTPSPS 
       460        470        480        490        500
TLSRAHIEQK DLQLDEKLHH SVLQTPDDLE ISEFPSECCS VMAGGTLTGW 
       510        520        530        540        550
HADVATVMWR RMLGILGDVN AIMDPEIHAQ VFDYLCELWQ NLAKIRDNLG 
       560        570        580        590        600
ISADNLTSPS PPVLIPPLRI LTPWLFKATM LTDKYKQGKL HAYKLICNTM 
       610        620        630        640        650
KRRQDVSPNR DFLTHFYNIM HCGLLHIDQD IVNTIIKHCS PQFFSLGLPG 
       660        670        680        690        700
ATMLIMDFII AAGRVASSAF LNAPRVEAQV LLGSLVCFPN LYCELPALHP 
       710        720        730        740        750
NIPDIAVSQF TDVKELIIKT VLSSARDEPS GPARCVALCS LGIWICEELV 
       760        770        780        790        800
HESHHPQIKE ALNVICVSLK FTNKTVAHVA CNMLHMLVHY VPRLQIHQPQ 
       810        820        830        840        850
SPLKIIQILI ATITHLLPST EASSYEMDKR LVVSLLLCLL DWIMALPLKT 
       860        870        880        890        900
LLQPVHATGA ENDKTEKSVL NCIYKVLHGC VYGAQSFSNP KYFPISLSDL 
       910        920        930        940        950
ASVDYDPFMH LESLKEPEPL HSPDSERSSK LQPVTEVKTQ MQQGLISIAA 
       960        970        980        990       1000
RTVITHLVNH LGHYPMSGGP AMLTSQVCEN HDNHYSESTE LSPELFESPN 
      1010       1020       1030       1040       1050
IQFFVLNNTT LVSCIQIRSE ESMPGGGLAA GLVSANSNVR IIVRDLSGKY 
      1060       1070       1080       1090       1100
SWDSAILYGP PIVSGLPEPT SFILSMSDQE KPEEPPTSNE CLEDIAVKDG 
      1110       1120       1130       1140       1150
LSLQLRRFRE TVPTWSTIRE EEDVLDELLQ YLGTTSPECL QRTGISLNVP 
      1160       1170       1180       1190       1200
APQPLCISEK QENDVINAIL KQYTEEKEFV EKHFNDLNMK ASEQDEPTPQ 
      1210       1220       1230       1240       1250
KPQSAFYYCR LLLSILGMNS WDKRRSFHLL KKNEKLLREL RNLDSRQCRE 
      1260       1270       1280       1290       1300
THKIAVFYVA EGQEDKYSIL TNIGGSQAYE DFVAGLGWEV NLTNHCGFMG 
      1310       1320       1330       1340       1350
GLQKNRSTGL TTPYFATSTV EVIFHVSTRM PSDSDDSLTK KLRHLGNDEV 
      1360       1370       1380       1390       1400
HIVWSEHTRD YRRGIIPTEF GDVLIVIYPM KNHMFSIQIM KKPEVPFFGP 
      1410       1420       1430       1440       1450
LFDGAIVNGK VLPIMVRSTA INASRALKSL IPLYQNFYEE RARYLQTIVQ 
      1460       1470       1480
HHLEPTTFED FAAQVFSPAP YHHFPADADH

Note: May be a partial isoform 1. No experimental confirmation available.

Show »

Length:1,480

Mass (Da):165,341

Checksum:ⁱ3628A0BE37D0D0BB

GO

Sequence cautionⁱ

The sequence BAA92774 differs from that shown. Reason: Erroneous termination at position 1745. Translated as Lys.Curated

The sequence BAC98046 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	420	L → V in BAC98046 (PubMed:14621295).Curated	1
Sequence conflictⁱ	651	L → S in AAL47577 (PubMed:12200424).Curated	1
Sequence conflictⁱ	724	P → L in AAL47577 (PubMed:12200424).Curated	1
Sequence conflictⁱ	775	E → V in AAL47577 (PubMed:12200424).Curated	1
Sequence conflictⁱ	869	D → G in AAL47577 (PubMed:12200424).Curated	1
Sequence conflictⁱ	1166	D → N in AAL47577 (PubMed:12200424).Curated	1
Sequence conflictⁱ	1365	I → V in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1398	I → T in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1494	T → P in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1586	G → S in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1634	Q → P in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1638	E → K in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1674	R → Q in BAA92774 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1775 – 1780	SWDKRR → WAAGIPGTNGG in AAL47577 (PubMed:12200424).Curated	6
Sequence conflictⁱ	1966 – 1968	VLP → SSA in AAL47577 (PubMed:12200424).Curated	3

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_011331	1 – 1337	Missing in isoform 6. 1 PublicationAdd BLAST	1337
Alternative sequenceⁱVSP_011332	1 – 1298	Missing in isoform 4. 1 PublicationAdd BLAST	1298
Alternative sequenceⁱVSP_011330	1 – 555	Missing in isoform 1S. 1 PublicationAdd BLAST	555
Alternative sequenceⁱVSP_011333	1035 – 1037	EIS → GNA in isoform 5. 2 Publications	3
Alternative sequenceⁱVSP_011334	1038 – 2035	Missing in isoform 5. 2 PublicationsAdd BLAST	998
Alternative sequenceⁱVSP_011335	1299 – 1304	WICEEL → MMRFVE in isoform 4. 1 Publication	6
Alternative sequenceⁱVSP_011336	1897 – 1904	LRHLGNDE → VSAEGKHF in isoform 6. 1 Publication	8
Alternative sequenceⁱVSP_011337	1905 – 2035	Missing in isoform 6. 1 PublicationAdd BLAST	131
Alternative sequenceⁱVSP_011338	2034 – 2035	DH → VGSYPEIPPSDAAPAAQVDG ADLASPMSPRTSKSR in isoform 2. 1 Publication	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY066011 mRNA. Translation: AAL47577.1. AY596972 mRNA. Translation: AAT49273.1. AY596973 mRNA. Translation: AAT49274.1. AY596974 mRNA. Translation: AAT49275.1. AK129236 mRNA. Translation: BAC98046.1. Different initiation. AB032400 mRNA. Translation: BAA92774.1. Sequence problems. AK042116 mRNA. Translation: BAC31171.1. AK083518 mRNA. Translation: BAC38939.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36452.1. [Q6GYP7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001003719.1. NM_001003719.2. NP_001106185.1. NM_001112714.2. [Q6GYP7-1] NP_001273192.1. NM_001286263.1. NP_064378.4. NM_019994.5. [Q6GYP7-1]
UniGeneⁱ	Mm.292180. Mm.398098.

Genome annotation databases

Ensemblⁱ	ENSMUST00000085385; ENSMUSP00000082503; ENSMUSG00000021027. [Q6GYP7-1] ENSMUST00000110687; ENSMUSP00000106315; ENSMUSG00000021027. [Q6GYP7-1]
GeneIDⁱ	56784.
KEGGⁱ	mmu:56784.
UCSC genome browser More...UCSCⁱ	uc007nou.2. mouse. [Q6GYP7-1] uc007nov.2. mouse. [Q6GYP7-2] uc007now.1. mouse. [Q6GYP7-5] uc007nox.2. mouse. [Q6GYP7-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY066011 mRNA. Translation: AAL47577.1. AY596972 mRNA. Translation: AAT49273.1. AY596973 mRNA. Translation: AAT49274.1. AY596974 mRNA. Translation: AAT49275.1. AK129236 mRNA. Translation: BAC98046.1. Different initiation. AB032400 mRNA. Translation: BAA92774.1. Sequence problems. AK042116 mRNA. Translation: BAC31171.1. AK083518 mRNA. Translation: BAC38939.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36452.1. [Q6GYP7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001003719.1. NM_001003719.2. NP_001106185.1. NM_001112714.2. [Q6GYP7-1] NP_001273192.1. NM_001286263.1. NP_064378.4. NM_019994.5. [Q6GYP7-1]
UniGeneⁱ	Mm.292180. Mm.398098.

3D structure databases

ProteinModelPortalⁱ	Q6GYP7.
SMRⁱ	Q6GYP7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	208171. 1 interactor.
IntActⁱ	Q6GYP7. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4096796.
STRINGⁱ	10090.ENSMUSP00000082503.

PTM databases

iPTMnetⁱ	Q6GYP7.
PhosphoSitePlusⁱ	Q6GYP7.

Proteomic databases

PaxDbⁱ	Q6GYP7.
PeptideAtlas More...PeptideAtlasⁱ	Q6GYP7.
PRIDEⁱ	Q6GYP7.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000085385; ENSMUSP00000082503; ENSMUSG00000021027. [Q6GYP7-1] ENSMUST00000110687; ENSMUSP00000106315; ENSMUSG00000021027. [Q6GYP7-1]
GeneIDⁱ	56784.
KEGGⁱ	mmu:56784.
UCSC genome browser More...UCSCⁱ	uc007nou.2. mouse. [Q6GYP7-1] uc007nov.2. mouse. [Q6GYP7-2] uc007now.1. mouse. [Q6GYP7-5] uc007nox.2. mouse. [Q6GYP7-4]

Organism-specific databases

CTDⁱ	253959.
MGIⁱ	MGI:1931050. Ralgapa1.
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3686. Eukaryota. ENOG410XTIX. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119182.
HOVERGENⁱ	HBG051842.
InParanoidⁱ	Q6GYP7.
OMAⁱ	CENHDNH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G005P.
PhylomeDBⁱ	Q6GYP7.
TreeFamⁱ	TF324484.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6GYP7.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021027.
CleanExⁱ	MM_GARNL1.
Genevisibleⁱ	Q6GYP7. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024. ARM-type_fold. IPR000331. Rap_GAP_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02145. Rap_GAP. 1 hit.
SUPFAMⁱ	SSF111347. SSF111347. 1 hit. SSF48371. SSF48371. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50085. RAPGAP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGPA1_MOUSE
Accessionⁱ	Q6GYP7Primary (citable) accession number: Q6GYP7 Secondary accession number(s): Q6GYP6 , Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	July 19, 2004
	Last modified:	June 7, 2017
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Caution

Was initially thought to act as a transcriptional regulator via its interaction with TCF3/E12.1 Publication

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6GYP7 (RGPA1_MOUSE)

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Ral GTPase-activating protein subunit alpha-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (6)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ