Q6GYP7 (RGPA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ral GTPase-activating protein subunit alpha-1

Alternative name(s):
GAP-related-interacting partner to E12
Short name=GRIPE
GTPase-activating RapGAP domain-like 1
Tuberin-like protein 1
p240

Gene names

Name:	Ralgapa1
Synonyms:	Garnl1, Kiaa0884, Tulip1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2035 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB By similarity. May interact with the HLH region of TCF3/isoform E12
Subunit structure	Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity By similarity. Interacts with the HLH region of TCF3/isoform E12 Ref.1
Subcellular location	Cytoplasm. Nucleus. Note: Translocated to the nucleus, when associated with TCF3/E12. Ref.1
Tissue specificity	Expressed during embryogenesis. Expressed in the adult brain, particularly in neurons of the cortex and hippocampus. Ref.1
Developmental stage	Expression decreased during development, but persists in the adult brain.
Sequence similarities	Contains 1 Rap-GAP domain.
Caution	Was initially thought (Ref.1) to act as a transcriptional regulator via its interaction with TCF3/E12.
Sequence caution	The sequence BAA92774.1 differs from that shown. Reason: Erroneous termination at position 1745. Translated as Lys. The sequence BAC98046.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of Ral GTPase activity Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-templated Inferred from direct assay Ref.1. Source: MGI
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: MGI mitochondrion Inferred from electronic annotation. Source: Ensembl nucleus Inferred from direct assay Ref.1. Source: MGI
Molecular_function	Ral GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6GYP7-1)

Also known as: 3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6GYP7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2034-2035: DH → VGSYPEIPPSDAAPAAQVDGADLASPMSPRTSKSR

Isoform 4 (identifier: Q6GYP7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1298: Missing.
     1299-1304: WICEEL → MMRFVE

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6GYP7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1037: EIS → GNA
     1038-2035: Missing.

Isoform 6 (identifier: Q6GYP7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1337: Missing.
     1897-1904: LRHLGNDE → VSAEGKHF
     1905-2035: Missing.

Note: No experimental confirmation available.

Isoform 1S (identifier: Q6GYP7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-555: Missing.

Note: May be a partial isoform 1. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2035	2035	Ral GTPase-activating protein subunit alpha-1		PRO_0000056754
Regions
	Domain	1795 – 2003	209	Rap-GAP
	Region	1326 – 2035	710	Minimal domain that binds to TCF3/E12
	Coiled coil	1713 – 1748	36	Potential
	Compositional bias	379 – 382	4	Poly-Ser
Amino acid modifications
	Modified residue	753	1	Phosphothreonine By similarity
	Modified residue	772	1	Phosphoserine By similarity
	Modified residue	777	1	Phosphothreonine By similarity
	Modified residue	796	1	Phosphoserine By similarity
	Modified residue	859	1	Phosphoserine Ref.6
	Modified residue	860	1	Phosphoserine Ref.6
	Modified residue	863	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 1337	1337	Missing in isoform 6.		VSP_011331
	Alternative sequence	1 – 1298	1298	Missing in isoform 4.		VSP_011332
	Alternative sequence	1 – 555	555	Missing in isoform 1S.		VSP_011330
	Alternative sequence	1035 – 1037	3	EIS → GNA in isoform 5.		VSP_011333
	Alternative sequence	1038 – 2035	998	Missing in isoform 5.		VSP_011334
	Alternative sequence	1299 – 1304	6	WICEEL → MMRFVE in isoform 4.		VSP_011335
	Alternative sequence	1897 – 1904	8	LRHLGNDE → VSAEGKHF in isoform 6.		VSP_011336
	Alternative sequence	1905 – 2035	131	Missing in isoform 6.		VSP_011337
	Alternative sequence	2034 – 2035	2	DH → VGSYPEIPPSDAAPAAQVDG ADLASPMSPRTSKSR in isoform 2.		VSP_011338
Experimental info
	Sequence conflict	420	1	L → V in BAC98046. Ref.3
	Sequence conflict	651	1	L → S in AAL47577. Ref.1
	Sequence conflict	724	1	P → L in AAL47577. Ref.1
	Sequence conflict	775	1	E → V in AAL47577. Ref.1
	Sequence conflict	869	1	D → G in AAL47577. Ref.1
	Sequence conflict	1166	1	D → N in AAL47577. Ref.1
	Sequence conflict	1365	1	I → V in BAA92774. Ref.4
	Sequence conflict	1398	1	I → T in BAA92774. Ref.4
	Sequence conflict	1494	1	T → P in BAA92774. Ref.4
	Sequence conflict	1586	1	G → S in BAA92774. Ref.4
	Sequence conflict	1634	1	Q → P in BAA92774. Ref.4
	Sequence conflict	1638	1	E → K in BAA92774. Ref.4
	Sequence conflict	1674	1	R → Q in BAA92774. Ref.4
	Sequence conflict	1775 – 1780	6	SWDKRR → WAAGIPGTNGG in AAL47577. Ref.1
	Sequence conflict	1966 – 1968	3	VLP → SSA in AAL47577. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (3) [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 1F4C3E24022EBB54	FASTA	2,035	229,389
	10 20 30 40 50 60 MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE 70 80 90 100 110 120 NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN 130 140 150 160 170 180 SLKIRREGVR LFLLWLQALQ DNCSKEQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLSL 190 200 210 220 230 240 QETQVTIEEV TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL 250 260 270 280 290 300 FSHFKKFYLP YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 310 320 330 340 350 360 ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK NDTVDKVDKS 370 380 390 400 410 420 AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL 430 440 450 460 470 480 LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEDTAITCS DIPCSETVAD HDSAIEDGEK 490 500 510 520 530 540 REEENGTSTS EHVRNSSWTK NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL 550 560 570 580 590 600 EPANEIKNLL DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 610 620 630 640 650 660 LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS LTYWEELATE 670 680 690 700 710 720 WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK GVGHEFQKVS VDKSFSRGWS 730 740 750 760 770 780 RDQPGQAPMR QRSATTTGSP GTEKARSIVR QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE 790 800 810 820 830 840 VFGALHEEQP LPRSSSTSDI LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE 850 860 870 880 890 900 FIAERLRSGN ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 910 920 930 940 950 960 SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST EEQEVASLTT 970 980 990 1000 1010 1020 LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ TPSPSTLSRA HIEQKDLQLD 1030 1040 1050 1060 1070 1080 EKLHHSVLQT PDDLEISEFP SECCSVMAGG TLTGWHADVA TVMWRRMLGI LGDVNAIMDP 1090 1100 1110 1120 1130 1140 EIHAQVFDYL CELWQNLAKI RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY 1150 1160 1170 1180 1190 1200 KQGKLHAYKL ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 1210 1220 1230 1240 1250 1260 LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL PALHPNIPDI 1270 1280 1290 1300 1310 1320 AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI CEELVHESHH PQIKEALNVI 1330 1340 1350 1360 1370 1380 CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ IHQPQSPLKI IQILIATITH LLPSTEASSY 1390 1400 1410 1420 1430 1440 EMDKRLVVSL LLCLLDWIMA LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ 1450 1460 1470 1480 1490 1500 SFSNPKYFPI SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 1510 1520 1530 1540 1550 1560 ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL FESPNIQFFV 1570 1580 1590 1600 1610 1620 LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD LSGKYSWDSA ILYGPPIVSG 1630 1640 1650 1660 1670 1680 LPEPTSFILS MSDQEKPEEP PTSNECLEDI AVKDGLSLQL RRFRETVPTW STIREEEDVL 1690 1700 1710 1720 1730 1740 DELLQYLGTT SPECLQRTGI SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN 1750 1760 1770 1780 1790 1800 DLNMKASEQD EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 1810 1820 1830 1840 1850 1860 RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH CGFMGGLQKN 1870 1880 1890 1900 1910 1920 RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL GNDEVHIVWS EHTRDYRRGI 1930 1940 1950 1960 1970 1980 IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV PFFGPLFDGA IVNGKVLPIM VRSTAINASR 1990 2000 2010 2020 2030 ALKSLIPLYQ NFYEERARYL QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADADH
	Isoform 2 [UniParc]. Checksum: CD55170FA5FBCF6B	FASTA	2,068	232,646
	10 20 30 40 50 60 MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE 70 80 90 100 110 120 NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN 130 140 150 160 170 180 SLKIRREGVR LFLLWLQALQ DNCSKEQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLSL 190 200 210 220 230 240 QETQVTIEEV TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL 250 260 270 280 290 300 FSHFKKFYLP YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 310 320 330 340 350 360 ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK NDTVDKVDKS 370 380 390 400 410 420 AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL 430 440 450 460 470 480 LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEDTAITCS DIPCSETVAD HDSAIEDGEK 490 500 510 520 530 540 REEENGTSTS EHVRNSSWTK NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL 550 560 570 580 590 600 EPANEIKNLL DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 610 620 630 640 650 660 LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS LTYWEELATE 670 680 690 700 710 720 WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK GVGHEFQKVS VDKSFSRGWS 730 740 750 760 770 780 RDQPGQAPMR QRSATTTGSP GTEKARSIVR QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE 790 800 810 820 830 840 VFGALHEEQP LPRSSSTSDI LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE 850 860 870 880 890 900 FIAERLRSGN ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 910 920 930 940 950 960 SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST EEQEVASLTT 970 980 990 1000 1010 1020 LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ TPSPSTLSRA HIEQKDLQLD 1030 1040 1050 1060 1070 1080 EKLHHSVLQT PDDLEISEFP SECCSVMAGG TLTGWHADVA TVMWRRMLGI LGDVNAIMDP 1090 1100 1110 1120 1130 1140 EIHAQVFDYL CELWQNLAKI RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY 1150 1160 1170 1180 1190 1200 KQGKLHAYKL ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS 1210 1220 1230 1240 1250 1260 LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL PALHPNIPDI 1270 1280 1290 1300 1310 1320 AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI CEELVHESHH PQIKEALNVI 1330 1340 1350 1360 1370 1380 CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ IHQPQSPLKI IQILIATITH LLPSTEASSY 1390 1400 1410 1420 1430 1440 EMDKRLVVSL LLCLLDWIMA LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ 1450 1460 1470 1480 1490 1500 SFSNPKYFPI SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL 1510 1520 1530 1540 1550 1560 ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL FESPNIQFFV 1570 1580 1590 1600 1610 1620 LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD LSGKYSWDSA ILYGPPIVSG 1630 1640 1650 1660 1670 1680 LPEPTSFILS MSDQEKPEEP PTSNECLEDI AVKDGLSLQL RRFRETVPTW STIREEEDVL 1690 1700 1710 1720 1730 1740 DELLQYLGTT SPECLQRTGI SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN 1750 1760 1770 1780 1790 1800 DLNMKASEQD EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS 1810 1820 1830 1840 1850 1860 RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH CGFMGGLQKN 1870 1880 1890 1900 1910 1920 RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL GNDEVHIVWS EHTRDYRRGI 1930 1940 1950 1960 1970 1980 IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV PFFGPLFDGA IVNGKVLPIM VRSTAINASR 1990 2000 2010 2020 2030 2040 ALKSLIPLYQ NFYEERARYL QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADAVGSYPEI 2050 2060 PPSDAAPAAQ VDGADLASPM SPRTSKSR
	Isoform 4 [UniParc]. Checksum: 3D72CD7AA1E1F7D4	FASTA	737	83,311
	10 20 30 40 50 60 MMRFVEVHES HHPQIKEALN VICVSLKFTN KTVAHVACNM LHMLVHYVPR LQIHQPQSPL 70 80 90 100 110 120 KIIQILIATI THLLPSTEAS SYEMDKRLVV SLLLCLLDWI MALPLKTLLQ PVHATGAEND 130 140 150 160 170 180 KTEKSVLNCI YKVLHGCVYG AQSFSNPKYF PISLSDLASV DYDPFMHLES LKEPEPLHSP 190 200 210 220 230 240 DSERSSKLQP VTEVKTQMQQ GLISIAARTV ITHLVNHLGH YPMSGGPAML TSQVCENHDN 250 260 270 280 290 300 HYSESTELSP ELFESPNIQF FVLNNTTLVS CIQIRSEESM PGGGLAAGLV SANSNVRIIV 310 320 330 340 350 360 RDLSGKYSWD SAILYGPPIV SGLPEPTSFI LSMSDQEKPE EPPTSNECLE DIAVKDGLSL 370 380 390 400 410 420 QLRRFRETVP TWSTIREEED VLDELLQYLG TTSPECLQRT GISLNVPAPQ PLCISEKQEN 430 440 450 460 470 480 DVINAILKQY TEEKEFVEKH FNDLNMKASE QDEPTPQKPQ SAFYYCRLLL SILGMNSWDK 490 500 510 520 530 540 RRSFHLLKKN EKLLRELRNL DSRQCRETHK IAVFYVAEGQ EDKYSILTNI GGSQAYEDFV 550 560 570 580 590 600 AGLGWEVNLT NHCGFMGGLQ KNRSTGLTTP YFATSTVEVI FHVSTRMPSD SDDSLTKKLR 610 620 630 640 650 660 HLGNDEVHIV WSEHTRDYRR GIIPTEFGDV LIVIYPMKNH MFSIQIMKKP EVPFFGPLFD 670 680 690 700 710 720 GAIVNGKVLP IMVRSTAINA SRALKSLIPL YQNFYEERAR YLQTIVQHHL EPTTFEDFAA 730 QVFSPAPYHH FPADADH
	Isoform 5 [UniParc]. Checksum: 23D34AB339388DC0	FASTA	1,037	117,170
	10 20 30 40 50 60 MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE 70 80 90 100 110 120 NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN 130 140 150 160 170 180 SLKIRREGVR LFLLWLQALQ DNCSKEQLWM FSCLIPGFSA PQSEYGPRTL DNLINPPLSL 190 200 210 220 230 240 QETQVTIEEV TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL 250 260 270 280 290 300 FSHFKKFYLP YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ 310 320 330 340 350 360 ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK NDTVDKVDKS 370 380 390 400 410 420 AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL 430 440 450 460 470 480 LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEDTAITCS DIPCSETVAD HDSAIEDGEK 490 500 510 520 530 540 REEENGTSTS EHVRNSSWTK NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL 550 560 570 580 590 600 EPANEIKNLL DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF 610 620 630 640 650 660 LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS LTYWEELATE 670 680 690 700 710 720 WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK GVGHEFQKVS VDKSFSRGWS 730 740 750 760 770 780 RDQPGQAPMR QRSATTTGSP GTEKARSIVR QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE 790 800 810 820 830 840 VFGALHEEQP LPRSSSTSDI LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE 850 860 870 880 890 900 FIAERLRSGN ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS 910 920 930 940 950 960 SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST EEQEVASLTT 970 980 990 1000 1010 1020 LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ TPSPSTLSRA HIEQKDLQLD 1030 EKLHHSVLQT PDDLGNA
	Isoform 6 [UniParc]. Checksum: 0B413D16DC68FE68	FASTA	567	63,656
	10 20 30 40 50 60 MLHMLVHYVP RLQIHQPQSP LKIIQILIAT ITHLLPSTEA SSYEMDKRLV VSLLLCLLDW 70 80 90 100 110 120 IMALPLKTLL QPVHATGAEN DKTEKSVLNC IYKVLHGCVY GAQSFSNPKY FPISLSDLAS 130 140 150 160 170 180 VDYDPFMHLE SLKEPEPLHS PDSERSSKLQ PVTEVKTQMQ QGLISIAART VITHLVNHLG 190 200 210 220 230 240 HYPMSGGPAM LTSQVCENHD NHYSESTELS PELFESPNIQ FFVLNNTTLV SCIQIRSEES 250 260 270 280 290 300 MPGGGLAAGL VSANSNVRII VRDLSGKYSW DSAILYGPPI VSGLPEPTSF ILSMSDQEKP 310 320 330 340 350 360 EEPPTSNECL EDIAVKDGLS LQLRRFRETV PTWSTIREEE DVLDELLQYL GTTSPECLQR 370 380 390 400 410 420 TGISLNVPAP QPLCISEKQE NDVINAILKQ YTEEKEFVEK HFNDLNMKAS EQDEPTPQKP 430 440 450 460 470 480 QSAFYYCRLL LSILGMNSWD KRRSFHLLKK NEKLLRELRN LDSRQCRETH KIAVFYVAEG 490 500 510 520 530 540 QEDKYSILTN IGGSQAYEDF VAGLGWEVNL TNHCGFMGGL QKNRSTGLTT PYFATSTVEV 550 560 IFHVSTRMPS DSDDSLTKKV SAEGKHF
	Isoform 1S [UniParc]. Checksum: 3628A0BE37D0D0BB	FASTA	1,480	165,341
	10 20 30 40 50 60 MCKRILNIYR YMVVQVSMDK KTWEQMLLVL LRVTESVLKM SSQAFLQFQG KKSMTLAGRL 70 80 90 100 110 120 AGPLFQTLIV AWIKANLNVY ISRELWDDLL SVLSSLTYWE ELATEWSLTM ETLTKVLARN 130 140 150 160 170 180 LYSLDLSDLP LDKLSEQKQK KHKGKGVGHE FQKVSVDKSF SRGWSRDQPG QAPMRQRSAT 190 200 210 220 230 240 TTGSPGTEKA RSIVRQKTVD IDDAQILPRS TRVRHFSQSE DTGNEVFGAL HEEQPLPRSS 250 260 270 280 290 300 STSDILEPFT VERAKVNKED TSPKLPPLNS ETGGNSANVP DLMDEFIAER LRSGNASTMT 310 320 330 340 350 360 RRGSSPGSLE IPKDLPDILN KQNQMRPVDD PGVPSEWTSP ASAGSSDLMS SDSHSDSFSA 370 380 390 400 410 420 FQCEGRKFDN FGFGTDIGIP SSADVDLGSG HHQSTEEQEV ASLTTLHLDS ETSSLNQQAF 430 440 450 460 470 480 SAEVATVTGS ESASPVHSAL GSRSQTPSPS TLSRAHIEQK DLQLDEKLHH SVLQTPDDLE 490 500 510 520 530 540 ISEFPSECCS VMAGGTLTGW HADVATVMWR RMLGILGDVN AIMDPEIHAQ VFDYLCELWQ 550 560 570 580 590 600 NLAKIRDNLG ISADNLTSPS PPVLIPPLRI LTPWLFKATM LTDKYKQGKL HAYKLICNTM 610 620 630 640 650 660 KRRQDVSPNR DFLTHFYNIM HCGLLHIDQD IVNTIIKHCS PQFFSLGLPG ATMLIMDFII 670 680 690 700 710 720 AAGRVASSAF LNAPRVEAQV LLGSLVCFPN LYCELPALHP NIPDIAVSQF TDVKELIIKT 730 740 750 760 770 780 VLSSARDEPS GPARCVALCS LGIWICEELV HESHHPQIKE ALNVICVSLK FTNKTVAHVA 790 800 810 820 830 840 CNMLHMLVHY VPRLQIHQPQ SPLKIIQILI ATITHLLPST EASSYEMDKR LVVSLLLCLL 850 860 870 880 890 900 DWIMALPLKT LLQPVHATGA ENDKTEKSVL NCIYKVLHGC VYGAQSFSNP KYFPISLSDL 910 920 930 940 950 960 ASVDYDPFMH LESLKEPEPL HSPDSERSSK LQPVTEVKTQ MQQGLISIAA RTVITHLVNH 970 980 990 1000 1010 1020 LGHYPMSGGP AMLTSQVCEN HDNHYSESTE LSPELFESPN IQFFVLNNTT LVSCIQIRSE 1030 1040 1050 1060 1070 1080 ESMPGGGLAA GLVSANSNVR IIVRDLSGKY SWDSAILYGP PIVSGLPEPT SFILSMSDQE 1090 1100 1110 1120 1130 1140 KPEEPPTSNE CLEDIAVKDG LSLQLRRFRE TVPTWSTIRE EEDVLDELLQ YLGTTSPECL 1150 1160 1170 1180 1190 1200 QRTGISLNVP APQPLCISEK QENDVINAIL KQYTEEKEFV EKHFNDLNMK ASEQDEPTPQ 1210 1220 1230 1240 1250 1260 KPQSAFYYCR LLLSILGMNS WDKRRSFHLL KKNEKLLREL RNLDSRQCRE THKIAVFYVA 1270 1280 1290 1300 1310 1320 EGQEDKYSIL TNIGGSQAYE DFVAGLGWEV NLTNHCGFMG GLQKNRSTGL TTPYFATSTV 1330 1340 1350 1360 1370 1380 EVIFHVSTRM PSDSDDSLTK KLRHLGNDEV HIVWSEHTRD YRRGIIPTEF GDVLIVIYPM 1390 1400 1410 1420 1430 1440 KNHMFSIQIM KKPEVPFFGP LFDGAIVNGK VLPIMVRSTA INASRALKSL IPLYQNFYEE 1450 1460 1470 1480 RARYLQTIVQ HHLEPTTFED FAAQVFSPAP YHHFPADADH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain." Heng J.I.T., Tan S.-S. J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1S), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TCF3/E12. Strain: C57BL/6J. Tissue: Forebrain.
[2]	"Cloning, genomic structure and expression profile of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes and its murine homolog." Schwarzbraun T., Vincent J.B., Schumacher A., Geschwind D.H., Oliveira J., Windpassinger C., Ofner L., Ledinegg M.K., Kroisel P.M., Wagner K., Petek E. Genomics 84:577-586(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: BALB/c.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Embryonic tail.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6). Strain: C57BL/6J. Tissue: Thymus.
[5]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 339-350, IDENTIFICATION BY MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[6]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[7]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY066011 mRNA. Translation: AAL47577.1. AY596972 mRNA. Translation: AAT49273.1. AY596973 mRNA. Translation: AAT49274.1. AY596974 mRNA. Translation: AAT49275.1. AK129236 mRNA. Translation: BAC98046.1. Different initiation. AB032400 mRNA. Translation: BAA92774.1. Sequence problems. AK042116 mRNA. Translation: BAC31171.1. AK083518 mRNA. Translation: BAC38939.1.
CCDS	CCDS36452.1. [Q6GYP7-1]
RefSeq	NP_001003719.1. NM_001003719.2. NP_001106185.1. NM_001112714.2. [Q6GYP7-1] NP_001273192.1. NM_001286263.1. NP_064378.4. NM_019994.5. [Q6GYP7-1]
UniGene	Mm.292180. Mm.398098.
3D structure databases
ProteinModelPortal	Q6GYP7.
SMR	Q6GYP7. Positions 1790-1955.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	208171. 1 interaction.
IntAct	Q6GYP7. 1 interaction.
MINT	MINT-4096796.
PTM databases
PhosphoSite	Q6GYP7.
Proteomic databases
MaxQB	Q6GYP7.
PaxDb	Q6GYP7.
PRIDE	Q6GYP7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000085385; ENSMUSP00000082503; ENSMUSG00000021027. [Q6GYP7-1] ENSMUST00000110687; ENSMUSP00000106315; ENSMUSG00000021027. [Q6GYP7-1]
GeneID	56784.
KEGG	mmu:56784.
UCSC	uc007nou.1. mouse. [Q6GYP7-1] uc007nov.1. mouse. [Q6GYP7-2] uc007now.1. mouse. [Q6GYP7-5] uc007nox.1. mouse. [Q6GYP7-4]
Organism-specific databases
CTD	253959.
MGI	MGI:1931050. Ralgapa1.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG250663.
GeneTree	ENSGT00390000017866.
HOVERGEN	HBG051842.
OMA	QVFDYLC.
OrthoDB	EOG7N63KR.
PhylomeDB	Q6GYP7.
TreeFam	TF324484.
Gene expression databases
ArrayExpress	Q6GYP7.
Bgee	Q6GYP7.
CleanEx	MM_GARNL1.
Genevestigator	Q6GYP7.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR000331. Rap_GAP_dom. [Graphical view]
Pfam	PF02145. Rap_GAP. 1 hit. [Graphical view]
SUPFAM	SSF48371. SSF48371. 1 hit.
PROSITE	PS50085. RAPGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	313310.
PRO	Q6GYP7.
SOURCE	Search...

Entry information

Entry name

RGPA1_MOUSE

Accession

Primary (citable) accession number: Q6GYP7
Secondary accession number(s): Q6GYP6 , Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	July 19, 2004
Last modified:	July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program