UniProtKB - Q6GYP7 (RGPA1_MOUSE)
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- BLAST>sp|Q6GYP7|RGPA1_MOUSE Ral GTPase-activating protein subunit alpha-1 OS=Mus musculus OX=10090 GN=Ralgapa1 PE=1 SV=1 MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFE NFVTIEASLKQKGHKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGN SLKIRREGVRLFLLWLQALQDNCSKEQLWMFSCLIPGFSAPQSEYGPRTLDNLINPPLSL QETQVTIEEVTPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSFL FSHFKKFYLPYIFPNICKENSLYHPVLDIPQIRPKPHYVMIKKDAETNETIYCTKEPFIQ ARVIVIRWLVSFWLEPKPHSGPNIPGMEGEVLPKNIQRAAASLVSREESKNDTVDKVDKS AEPEQSHSNTSTLTEREPSSSSLCSIDEEHLTDIEIVRRVFSSKRSNVNFVTEIFRQAFL LPICEAAAMRKVVKVYQEWIQQEEKPLFMQEPEDTAITCSDIPCSETVADHDSAIEDGEK REEENGTSTSEHVRNSSWTKNGSYQEAFHVCEEATEQNIQAGTQAVLQVFIINSSNIFLL EPANEIKNLLDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVLKMSSQAF LQFQGKKSMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATE WSLTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWS RDQPGQAPMRQRSATTTGSPGTEKARSIVRQKTVDIDDAQILPRSTRVRHFSQSEDTGNE VFGALHEEQPLPRSSSTSDILEPFTVERAKVNKEDTSPKLPPLNSETGGNSANVPDLMDE FIAERLRSGNASTMTRRGSSPGSLEIPKDLPDILNKQNQMRPVDDPGVPSEWTSPASAGS SDLMSSDSHSDSFSAFQCEGRKFDNFGFGTDIGIPSSADVDLGSGHHQSTEEQEVASLTT LHLDSETSSLNQQAFSAEVATVTGSESASPVHSALGSRSQTPSPSTLSRAHIEQKDLQLD EKLHHSVLQTPDDLEISEFPSECCSVMAGGTLTGWHADVATVMWRRMLGILGDVNAIMDP EIHAQVFDYLCELWQNLAKIRDNLGISADNLTSPSPPVLIPPLRILTPWLFKATMLTDKY KQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHIDQDIVNTIIKHCSPQFFS LGLPGATMLIMDFIIAAGRVASSAFLNAPRVEAQVLLGSLVCFPNLYCELPALHPNIPDI AVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEELVHESHHPQIKEALNVI CVSLKFTNKTVAHVACNMLHMLVHYVPRLQIHQPQSPLKIIQILIATITHLLPSTEASSY EMDKRLVVSLLLCLLDWIMALPLKTLLQPVHATGAENDKTEKSVLNCIYKVLHGCVYGAQ SFSNPKYFPISLSDLASVDYDPFMHLESLKEPEPLHSPDSERSSKLQPVTEVKTQMQQGL ISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHDNHYSESTELSPELFESPNIQFFV LNNTTLVSCIQIRSEESMPGGGLAAGLVSANSNVRIIVRDLSGKYSWDSAILYGPPIVSG LPEPTSFILSMSDQEKPEEPPTSNECLEDIAVKDGLSLQLRRFRETVPTWSTIREEEDVL DELLQYLGTTSPECLQRTGISLNVPAPQPLCISEKQENDVINAILKQYTEEKEFVEKHFN DLNMKASEQDEPTPQKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDS RQCRETHKIAVFYVAEGQEDKYSILTNIGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKN RSTGLTTPYFATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGI IPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLFDGAIVNGKVLPIMVRSTAINASR ALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFEDFAAQVFSPAPYHHFPADADH
- Align
Protein
Ral GTPase-activating protein subunit alpha-1
Gene
Ralgapa1
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12.By similarity
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- GTPase activator activity Source: UniProtKB
- protein heterodimerization activity Source: MGI
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
- activation of GTPase activity Source: UniProtKB
- regulation of small GTPase mediated signal transduction Source: InterPro
- regulation of transcription, DNA-templated Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
| Molecular function | GTPase activation |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Ral GTPase-activating protein subunit alpha-1Alternative name(s): GAP-related-interacting partner to E12 Short name: GRIPE GTPase-activating RapGAP domain-like 1 Tuberin-like protein 1 p240 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:Ralgapa1 Synonyms:Garnl1, Kiaa0884, Tulip1 |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Mus musculus (Mouse) |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the <span class="caps">NCBI</span> to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 10090 [NCBI] |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
| <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Mouse genome database (MGD) from Mouse Genome Informatics (MGI) More...MGIi | MGI:1931050. Ralgapa1. |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Nucleus
- Nucleus 1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain."
Heng J.I.T., Tan S.-S.
J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1S), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TCF3/E12.
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain."
Heng J.I.T., Tan S.-S.
J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1S), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TCF3/E12.
Note: Translocated to the nucleus, when associated with TCF3/E12.- Cytoplasm 1 Publication
Nucleus
- nucleus Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
Other locations
- cytoplasm Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Cytoplasm, Nucleus<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000056754 | 1 – 2035 | Ral GTPase-activating protein subunit alpha-1Add BLAST | 2035 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 710 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 720 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 753 | PhosphothreonineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More…</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 772 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More…</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 777 | PhosphothreonineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 796 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 859 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More…</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 860 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More…</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 863 | PhosphoserineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More…</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 985 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 989 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 993 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 999 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1001 | PhosphothreonineCombined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More…</a></p> Manual assertion inferred from combination of experimental and computational evidencei
| 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1003 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 | |
| <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei | 1477 | PhosphoserineBy similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toi | 1 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi
PhosphoproteinProteomic databases
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q6GYP7. |
PeptideAtlas More...PeptideAtlasi | Q6GYP7. |
PRoteomics IDEntifications database More...PRIDEi | Q6GYP7. |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q6GYP7. |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q6GYP7. |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Expressed during embryogenesis. Expressed in the adult brain, particularly in neurons of the cortex and hippocampus.1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain."
Heng J.I.T., Tan S.-S.
J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1S), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TCF3/E12.
<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei
Expression decreased during development, but persists in the adult brain.
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSMUSG00000021027. |
CleanEx database of gene expression profiles More...CleanExi | MM_GARNL1. |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q6GYP7. baseline and differential. |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q6GYP7. MM. |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity (By similarity). Interacts with the HLH region of TCF3/isoform E12.By similarity1 Publication
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain."
Heng J.I.T., Tan S.-S.
J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1S), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TCF3/E12.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- protein heterodimerization activity Source: MGI
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 208171. 2 interactors. |
Protein interaction database and analysis system More...IntActi | Q6GYP7. 1 interactor. |
Molecular INTeraction database More...MINTi | Q6GYP7. |
STRING: functional protein association networks More...STRINGi | 10090.ENSMUSP00000082503. |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q6GYP7. |
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q6GYP7. |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 1795 – 2003 | Rap-GAPPROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More…</a></p> Manual assertion according to rulesi Add BLAST | 209 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 1326 – 2035 | Minimal domain that binds to TCF3/E12Add BLAST | 710 |
Coiled coil
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili | 1713 – 1748 | Sequence analysisAdd BLAST | 36 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi | 379 – 382 | Poly-Ser | 4 |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini
Coiled coilPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG3686. Eukaryota. ENOG410XTIX. LUCA. |
Ensembl GeneTree More...GeneTreei | ENSGT00760000119182. |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG051842. |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q6GYP7. |
Identification of Orthologs from Complete Genome Data More...OMAi | CENHDNH. |
Database of Orthologous Groups More...OrthoDBi | EOG091G005P. |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q6GYP7. |
TreeFam database of animal gene trees More...TreeFami | TF324484. |
Family and domain databases
Gene3D Structural and Functional Annotation of Protein Families More...Gene3Di | 3.40.50.11210. 1 hit. |
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR016024. ARM-type_fold. IPR035974. Rap/Ran-GAP_sf. IPR000331. Rap_GAP_dom. IPR027107. Tuberin/Ral-act_asu. |
The PANTHER Classification System More...PANTHERi | PTHR10063. PTHR10063. 1 hit. |
Pfam protein domain database More...Pfami | View protein in Pfam PF02145. Rap_GAP. 1 hit. |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF111347. SSF111347. 1 hit. SSF48371. SSF48371. 1 hit. |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS50085. RAPGAP. 1 hit. |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basket
Isoform 1 (identifier: Q6GYP7-1) [UniParc]FASTAAdd to basketAdded to basketShow »
Also known as: 3
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH
60 70 80 90 100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH
110 120 130 140 150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM
160 170 180 190 200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD
210 220 230 240 250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP
260 270 280 290 300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ
310 320 330 340 350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK
360 370 380 390 400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV
410 420 430 440 450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ
460 470 480 490 500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK
510 520 530 540 550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL
560 570 580 590 600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF
610 620 630 640 650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS
660 670 680 690 700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK
710 720 730 740 750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR
760 770 780 790 800
QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI
810 820 830 840 850
LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE FIAERLRSGN
860 870 880 890 900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS
910 920 930 940 950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST
960 970 980 990 1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ
1010 1020 1030 1040 1050
TPSPSTLSRA HIEQKDLQLD EKLHHSVLQT PDDLEISEFP SECCSVMAGG
1060 1070 1080 1090 1100
TLTGWHADVA TVMWRRMLGI LGDVNAIMDP EIHAQVFDYL CELWQNLAKI
1110 1120 1130 1140 1150
RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY KQGKLHAYKL
1160 1170 1180 1190 1200
ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS
1210 1220 1230 1240 1250
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL
1260 1270 1280 1290 1300
PALHPNIPDI AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI
1310 1320 1330 1340 1350
CEELVHESHH PQIKEALNVI CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ
1360 1370 1380 1390 1400
IHQPQSPLKI IQILIATITH LLPSTEASSY EMDKRLVVSL LLCLLDWIMA
1410 1420 1430 1440 1450
LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ SFSNPKYFPI
1460 1470 1480 1490 1500
SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL
1510 1520 1530 1540 1550
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL
1560 1570 1580 1590 1600
FESPNIQFFV LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD
1610 1620 1630 1640 1650
LSGKYSWDSA ILYGPPIVSG LPEPTSFILS MSDQEKPEEP PTSNECLEDI
1660 1670 1680 1690 1700
AVKDGLSLQL RRFRETVPTW STIREEEDVL DELLQYLGTT SPECLQRTGI
1710 1720 1730 1740 1750
SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN DLNMKASEQD
1760 1770 1780 1790 1800
EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS
1810 1820 1830 1840 1850
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH
1860 1870 1880 1890 1900
CGFMGGLQKN RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL
1910 1920 1930 1940 1950
GNDEVHIVWS EHTRDYRRGI IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV
1960 1970 1980 1990 2000
PFFGPLFDGA IVNGKVLPIM VRSTAINASR ALKSLIPLYQ NFYEERARYL
2010 2020 2030
QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADADH
Length:2,035
Mass (Da):229,389
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i1F4C3E24022EBB54
Isoform 2 (identifier: Q6GYP7-2) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
2034-2035: DH → VGSYPEIPPSDAAPAAQVDGADLASPMSPRTSKSR
10 20 30 40 50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH
60 70 80 90 100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH
110 120 130 140 150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM
160 170 180 190 200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD
210 220 230 240 250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP
260 270 280 290 300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ
310 320 330 340 350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK
360 370 380 390 400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV
410 420 430 440 450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ
460 470 480 490 500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK
510 520 530 540 550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL
560 570 580 590 600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF
610 620 630 640 650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS
660 670 680 690 700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK
710 720 730 740 750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR
760 770 780 790 800
QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI
810 820 830 840 850
LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE FIAERLRSGN
860 870 880 890 900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS
910 920 930 940 950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST
960 970 980 990 1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ
1010 1020 1030 1040 1050
TPSPSTLSRA HIEQKDLQLD EKLHHSVLQT PDDLEISEFP SECCSVMAGG
1060 1070 1080 1090 1100
TLTGWHADVA TVMWRRMLGI LGDVNAIMDP EIHAQVFDYL CELWQNLAKI
1110 1120 1130 1140 1150
RDNLGISADN LTSPSPPVLI PPLRILTPWL FKATMLTDKY KQGKLHAYKL
1160 1170 1180 1190 1200
ICNTMKRRQD VSPNRDFLTH FYNIMHCGLL HIDQDIVNTI IKHCSPQFFS
1210 1220 1230 1240 1250
LGLPGATMLI MDFIIAAGRV ASSAFLNAPR VEAQVLLGSL VCFPNLYCEL
1260 1270 1280 1290 1300
PALHPNIPDI AVSQFTDVKE LIIKTVLSSA RDEPSGPARC VALCSLGIWI
1310 1320 1330 1340 1350
CEELVHESHH PQIKEALNVI CVSLKFTNKT VAHVACNMLH MLVHYVPRLQ
1360 1370 1380 1390 1400
IHQPQSPLKI IQILIATITH LLPSTEASSY EMDKRLVVSL LLCLLDWIMA
1410 1420 1430 1440 1450
LPLKTLLQPV HATGAENDKT EKSVLNCIYK VLHGCVYGAQ SFSNPKYFPI
1460 1470 1480 1490 1500
SLSDLASVDY DPFMHLESLK EPEPLHSPDS ERSSKLQPVT EVKTQMQQGL
1510 1520 1530 1540 1550
ISIAARTVIT HLVNHLGHYP MSGGPAMLTS QVCENHDNHY SESTELSPEL
1560 1570 1580 1590 1600
FESPNIQFFV LNNTTLVSCI QIRSEESMPG GGLAAGLVSA NSNVRIIVRD
1610 1620 1630 1640 1650
LSGKYSWDSA ILYGPPIVSG LPEPTSFILS MSDQEKPEEP PTSNECLEDI
1660 1670 1680 1690 1700
AVKDGLSLQL RRFRETVPTW STIREEEDVL DELLQYLGTT SPECLQRTGI
1710 1720 1730 1740 1750
SLNVPAPQPL CISEKQENDV INAILKQYTE EKEFVEKHFN DLNMKASEQD
1760 1770 1780 1790 1800
EPTPQKPQSA FYYCRLLLSI LGMNSWDKRR SFHLLKKNEK LLRELRNLDS
1810 1820 1830 1840 1850
RQCRETHKIA VFYVAEGQED KYSILTNIGG SQAYEDFVAG LGWEVNLTNH
1860 1870 1880 1890 1900
CGFMGGLQKN RSTGLTTPYF ATSTVEVIFH VSTRMPSDSD DSLTKKLRHL
1910 1920 1930 1940 1950
GNDEVHIVWS EHTRDYRRGI IPTEFGDVLI VIYPMKNHMF SIQIMKKPEV
1960 1970 1980 1990 2000
PFFGPLFDGA IVNGKVLPIM VRSTAINASR ALKSLIPLYQ NFYEERARYL
2010 2020 2030 2040 2050
QTIVQHHLEP TTFEDFAAQV FSPAPYHHFP ADAVGSYPEI PPSDAAPAAQ
2060
VDGADLASPM SPRTSKSR
Length:2,068
Mass (Da):232,646
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:iCD55170FA5FBCF6B
Isoform 4 (identifier: Q6GYP7-3) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-1298: Missing.
1299-1304: WICEEL → MMRFVE
10 20 30 40 50
MMRFVEVHES HHPQIKEALN VICVSLKFTN KTVAHVACNM LHMLVHYVPR
60 70 80 90 100
LQIHQPQSPL KIIQILIATI THLLPSTEAS SYEMDKRLVV SLLLCLLDWI
110 120 130 140 150
MALPLKTLLQ PVHATGAEND KTEKSVLNCI YKVLHGCVYG AQSFSNPKYF
160 170 180 190 200
PISLSDLASV DYDPFMHLES LKEPEPLHSP DSERSSKLQP VTEVKTQMQQ
210 220 230 240 250
GLISIAARTV ITHLVNHLGH YPMSGGPAML TSQVCENHDN HYSESTELSP
260 270 280 290 300
ELFESPNIQF FVLNNTTLVS CIQIRSEESM PGGGLAAGLV SANSNVRIIV
310 320 330 340 350
RDLSGKYSWD SAILYGPPIV SGLPEPTSFI LSMSDQEKPE EPPTSNECLE
360 370 380 390 400
DIAVKDGLSL QLRRFRETVP TWSTIREEED VLDELLQYLG TTSPECLQRT
410 420 430 440 450
GISLNVPAPQ PLCISEKQEN DVINAILKQY TEEKEFVEKH FNDLNMKASE
460 470 480 490 500
QDEPTPQKPQ SAFYYCRLLL SILGMNSWDK RRSFHLLKKN EKLLRELRNL
510 520 530 540 550
DSRQCRETHK IAVFYVAEGQ EDKYSILTNI GGSQAYEDFV AGLGWEVNLT
560 570 580 590 600
NHCGFMGGLQ KNRSTGLTTP YFATSTVEVI FHVSTRMPSD SDDSLTKKLR
610 620 630 640 650
HLGNDEVHIV WSEHTRDYRR GIIPTEFGDV LIVIYPMKNH MFSIQIMKKP
660 670 680 690 700
EVPFFGPLFD GAIVNGKVLP IMVRSTAINA SRALKSLIPL YQNFYEERAR
710 720 730
YLQTIVQHHL EPTTFEDFAA QVFSPAPYHH FPADADH
Note: No experimental confirmation available.
Show »Length:737
Mass (Da):83,311
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i3D72CD7AA1E1F7D4
Isoform 5 (identifier: Q6GYP7-4) [UniParc]FASTAAdd to basketAdded to basketShow »
The sequence of this isoform differs from the canonical sequence as follows:
1035-1037: EIS → GNA
1038-2035: Missing.
10 20 30 40 50
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH
60 70 80 90 100
FSHIYYVFFE NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH
110 120 130 140 150
QRWQFHSIGL ILKKLLHTGN SLKIRREGVR LFLLWLQALQ DNCSKEQLWM
160 170 180 190 200
FSCLIPGFSA PQSEYGPRTL DNLINPPLSL QETQVTIEEV TPLVPPQSGD
210 220 230 240 250
KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL FSHFKKFYLP
260 270 280 290 300
YIFPNICKEN SLYHPVLDIP QIRPKPHYVM IKKDAETNET IYCTKEPFIQ
310 320 330 340 350
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREESK
360 370 380 390 400
NDTVDKVDKS AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV
410 420 430 440 450
FSSKRSNVNF VTEIFRQAFL LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ
460 470 480 490 500
EPEDTAITCS DIPCSETVAD HDSAIEDGEK REEENGTSTS EHVRNSSWTK
510 520 530 540 550
NGSYQEAFHV CEEATEQNIQ AGTQAVLQVF IINSSNIFLL EPANEIKNLL
560 570 580 590 600
DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF
610 620 630 640 650
LQFQGKKSMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS
660 670 680 690 700
LTYWEELATE WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK
710 720 730 740 750
GVGHEFQKVS VDKSFSRGWS RDQPGQAPMR QRSATTTGSP GTEKARSIVR
760 770 780 790 800
QKTVDIDDAQ ILPRSTRVRH FSQSEDTGNE VFGALHEEQP LPRSSSTSDI
810 820 830 840 850
LEPFTVERAK VNKEDTSPKL PPLNSETGGN SANVPDLMDE FIAERLRSGN
860 870 880 890 900
ASTMTRRGSS PGSLEIPKDL PDILNKQNQM RPVDDPGVPS EWTSPASAGS
910 920 930 940 950
SDLMSSDSHS DSFSAFQCEG RKFDNFGFGT DIGIPSSADV DLGSGHHQST
960 970 980 990 1000
EEQEVASLTT LHLDSETSSL NQQAFSAEVA TVTGSESASP VHSALGSRSQ
1010 1020 1030
TPSPSTLSRA HIEQKDLQLD EKLHHSVLQT PDDLGNA
Length:1,037
Mass (Da):117,170
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i23D34AB339388DC0
Isoform 6 (identifier: Q6GYP7-5) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-1337: Missing.
1897-1904: LRHLGNDE → VSAEGKHF
1905-2035: Missing.
10 20 30 40 50
MLHMLVHYVP RLQIHQPQSP LKIIQILIAT ITHLLPSTEA SSYEMDKRLV
60 70 80 90 100
VSLLLCLLDW IMALPLKTLL QPVHATGAEN DKTEKSVLNC IYKVLHGCVY
110 120 130 140 150
GAQSFSNPKY FPISLSDLAS VDYDPFMHLE SLKEPEPLHS PDSERSSKLQ
160 170 180 190 200
PVTEVKTQMQ QGLISIAART VITHLVNHLG HYPMSGGPAM LTSQVCENHD
210 220 230 240 250
NHYSESTELS PELFESPNIQ FFVLNNTTLV SCIQIRSEES MPGGGLAAGL
260 270 280 290 300
VSANSNVRII VRDLSGKYSW DSAILYGPPI VSGLPEPTSF ILSMSDQEKP
310 320 330 340 350
EEPPTSNECL EDIAVKDGLS LQLRRFRETV PTWSTIREEE DVLDELLQYL
360 370 380 390 400
GTTSPECLQR TGISLNVPAP QPLCISEKQE NDVINAILKQ YTEEKEFVEK
410 420 430 440 450
HFNDLNMKAS EQDEPTPQKP QSAFYYCRLL LSILGMNSWD KRRSFHLLKK
460 470 480 490 500
NEKLLRELRN LDSRQCRETH KIAVFYVAEG QEDKYSILTN IGGSQAYEDF
510 520 530 540 550
VAGLGWEVNL TNHCGFMGGL QKNRSTGLTT PYFATSTVEV IFHVSTRMPS
560
DSDDSLTKKV SAEGKHF
Note: No experimental confirmation available.
Show »Length:567
Mass (Da):63,656
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i0B413D16DC68FE68
Isoform 1S (identifier: Q6GYP7-6) [UniParc]FASTAAdd to basketAdded to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-555: Missing.
10 20 30 40 50
MCKRILNIYR YMVVQVSMDK KTWEQMLLVL LRVTESVLKM SSQAFLQFQG
60 70 80 90 100
KKSMTLAGRL AGPLFQTLIV AWIKANLNVY ISRELWDDLL SVLSSLTYWE
110 120 130 140 150
ELATEWSLTM ETLTKVLARN LYSLDLSDLP LDKLSEQKQK KHKGKGVGHE
160 170 180 190 200
FQKVSVDKSF SRGWSRDQPG QAPMRQRSAT TTGSPGTEKA RSIVRQKTVD
210 220 230 240 250
IDDAQILPRS TRVRHFSQSE DTGNEVFGAL HEEQPLPRSS STSDILEPFT
260 270 280 290 300
VERAKVNKED TSPKLPPLNS ETGGNSANVP DLMDEFIAER LRSGNASTMT
310 320 330 340 350
RRGSSPGSLE IPKDLPDILN KQNQMRPVDD PGVPSEWTSP ASAGSSDLMS
360 370 380 390 400
SDSHSDSFSA FQCEGRKFDN FGFGTDIGIP SSADVDLGSG HHQSTEEQEV
410 420 430 440 450
ASLTTLHLDS ETSSLNQQAF SAEVATVTGS ESASPVHSAL GSRSQTPSPS
460 470 480 490 500
TLSRAHIEQK DLQLDEKLHH SVLQTPDDLE ISEFPSECCS VMAGGTLTGW
510 520 530 540 550
HADVATVMWR RMLGILGDVN AIMDPEIHAQ VFDYLCELWQ NLAKIRDNLG
560 570 580 590 600
ISADNLTSPS PPVLIPPLRI LTPWLFKATM LTDKYKQGKL HAYKLICNTM
610 620 630 640 650
KRRQDVSPNR DFLTHFYNIM HCGLLHIDQD IVNTIIKHCS PQFFSLGLPG
660 670 680 690 700
ATMLIMDFII AAGRVASSAF LNAPRVEAQV LLGSLVCFPN LYCELPALHP
710 720 730 740 750
NIPDIAVSQF TDVKELIIKT VLSSARDEPS GPARCVALCS LGIWICEELV
760 770 780 790 800
HESHHPQIKE ALNVICVSLK FTNKTVAHVA CNMLHMLVHY VPRLQIHQPQ
810 820 830 840 850
SPLKIIQILI ATITHLLPST EASSYEMDKR LVVSLLLCLL DWIMALPLKT
860 870 880 890 900
LLQPVHATGA ENDKTEKSVL NCIYKVLHGC VYGAQSFSNP KYFPISLSDL
910 920 930 940 950
ASVDYDPFMH LESLKEPEPL HSPDSERSSK LQPVTEVKTQ MQQGLISIAA
960 970 980 990 1000
RTVITHLVNH LGHYPMSGGP AMLTSQVCEN HDNHYSESTE LSPELFESPN
1010 1020 1030 1040 1050
IQFFVLNNTT LVSCIQIRSE ESMPGGGLAA GLVSANSNVR IIVRDLSGKY
1060 1070 1080 1090 1100
SWDSAILYGP PIVSGLPEPT SFILSMSDQE KPEEPPTSNE CLEDIAVKDG
1110 1120 1130 1140 1150
LSLQLRRFRE TVPTWSTIRE EEDVLDELLQ YLGTTSPECL QRTGISLNVP
1160 1170 1180 1190 1200
APQPLCISEK QENDVINAIL KQYTEEKEFV EKHFNDLNMK ASEQDEPTPQ
1210 1220 1230 1240 1250
KPQSAFYYCR LLLSILGMNS WDKRRSFHLL KKNEKLLREL RNLDSRQCRE
1260 1270 1280 1290 1300
THKIAVFYVA EGQEDKYSIL TNIGGSQAYE DFVAGLGWEV NLTNHCGFMG
1310 1320 1330 1340 1350
GLQKNRSTGL TTPYFATSTV EVIFHVSTRM PSDSDDSLTK KLRHLGNDEV
1360 1370 1380 1390 1400
HIVWSEHTRD YRRGIIPTEF GDVLIVIYPM KNHMFSIQIM KKPEVPFFGP
1410 1420 1430 1440 1450
LFDGAIVNGK VLPIMVRSTA INASRALKSL IPLYQNFYEE RARYLQTIVQ
1460 1470 1480
HHLEPTTFED FAAQVFSPAP YHHFPADADH
Note: May be a partial isoform 1. No experimental confirmation available.
Show »Length:1,480
Mass (Da):165,341
<p>The checksum is a form of redundancy check that is calculated
from the sequence. It is useful for tracking sequence updates.</p>
<p>It should be noted that while, in theory, two different sequences could
have the same checksum value, the likelihood that this would happen
is extremely low.</p>
<p>However UniProtKB may contain entries with identical sequences in case
of multiple genes (paralogs).</p>
<p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64)
using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1.
The algorithm is described in the ISO 3309 standard.
</p>
<p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br />
<strong>Cyclic redundancy and other checksums</strong><br />
<a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p>
Checksum:i3628A0BE37D0D0BB
<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
The sequence BAA92774 differs from that shown. Reason: Erroneous termination at position 1745. Translated as Lys.Curated
The sequence BAC98046 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 420 | L → V in BAC98046 (PubMed:14621295).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 651 | L → S in AAL47577 (PubMed:12200424).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 724 | P → L in AAL47577 (PubMed:12200424).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 775 | E → V in AAL47577 (PubMed:12200424).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 869 | D → G in AAL47577 (PubMed:12200424).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1166 | D → N in AAL47577 (PubMed:12200424).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1365 | I → V in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1398 | I → T in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1494 | T → P in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1586 | G → S in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1634 | Q → P in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1638 | E → K in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1674 | R → Q in BAA92774 (PubMed:16141072).Curated | 1 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1775 – 1780 | SWDKRR → WAAGIPGTNGG in AAL47577 (PubMed:12200424).Curated | 6 | |
| <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 1966 – 1968 | VLP → SSA in AAL47577 (PubMed:12200424).Curated | 3 |
Alternative sequence
Sequence databases
| Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AY066011 mRNA. Translation: AAL47577.1. AY596972 mRNA. Translation: AAT49273.1. AY596973 mRNA. Translation: AAT49274.1. AY596974 mRNA. Translation: AAT49275.1. AK129236 mRNA. Translation: BAC98046.1. Different initiation. AB032400 mRNA. Translation: BAA92774.1. Sequence problems. AK042116 mRNA. Translation: BAC31171.1. AK083518 mRNA. Translation: BAC38939.1. |
The Consensus CDS (CCDS) project More...CCDSi | CCDS36452.1. [Q6GYP7-1] |
NCBI Reference Sequences More...RefSeqi | NP_001003719.1. NM_001003719.2. NP_001106185.1. NM_001112714.2. [Q6GYP7-1] NP_001273192.1. NM_001286263.1. NP_064378.4. NM_019994.5. [Q6GYP7-1] |
UniGene gene-oriented nucleotide sequence clusters More...UniGenei | Mm.292180. Mm.398098. |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENSMUST00000085385; ENSMUSP00000082503; ENSMUSG00000021027. [Q6GYP7-1] ENSMUST00000110687; ENSMUSP00000106315; ENSMUSG00000021027. [Q6GYP7-1] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 56784. |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | mmu:56784. |
UCSC genome browser More...UCSCi | uc007nou.2. mouse. [Q6GYP7-1] uc007nov.2. mouse. [Q6GYP7-2] uc007now.1. mouse. [Q6GYP7-5] uc007nox.2. mouse. [Q6GYP7-4] |
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi
Alternative splicing<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
| Protein | Similar proteins | Organisms | Length | Cluster ID | Cluster name | Size | |
|---|---|---|---|---|---|---|---|
| Q6GYP7 | Q6GYP7-6 | 2,035 | UniRef100_Q6GYP7 | Cluster: Ral GTPase-activating protein subunit alpha-1 | 2 |
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
| Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AY066011 mRNA. Translation: AAL47577.1. AY596972 mRNA. Translation: AAT49273.1. AY596973 mRNA. Translation: AAT49274.1. AY596974 mRNA. Translation: AAT49275.1. AK129236 mRNA. Translation: BAC98046.1. Different initiation. AB032400 mRNA. Translation: BAA92774.1. Sequence problems. AK042116 mRNA. Translation: BAC31171.1. AK083518 mRNA. Translation: BAC38939.1. |
The Consensus CDS (CCDS) project More...CCDSi | CCDS36452.1. [Q6GYP7-1] |
NCBI Reference Sequences More...RefSeqi | NP_001003719.1. NM_001003719.2. NP_001106185.1. NM_001112714.2. [Q6GYP7-1] NP_001273192.1. NM_001286263.1. NP_064378.4. NM_019994.5. [Q6GYP7-1] |
UniGene gene-oriented nucleotide sequence clusters More...UniGenei | Mm.292180. Mm.398098. |
3D structure databases
Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase More...ProteinModelPortali | Q6GYP7. |
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q6GYP7. |
Database of comparative protein structure models More...ModBasei | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGrid) More...BioGridi | 208171. 2 interactors. |
Protein interaction database and analysis system More...IntActi | Q6GYP7. 1 interactor. |
Molecular INTeraction database More...MINTi | Q6GYP7. |
STRING: functional protein association networks More...STRINGi | 10090.ENSMUSP00000082503. |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q6GYP7. |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q6GYP7. |
Proteomic databases
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q6GYP7. |
PeptideAtlas More...PeptideAtlasi | Q6GYP7. |
PRoteomics IDEntifications database More...PRIDEi | Q6GYP7. |
Protocols and materials databases
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENSMUST00000085385; ENSMUSP00000082503; ENSMUSG00000021027. [Q6GYP7-1] ENSMUST00000110687; ENSMUSP00000106315; ENSMUSG00000021027. [Q6GYP7-1] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 56784. |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | mmu:56784. |
UCSC genome browser More...UCSCi | uc007nou.2. mouse. [Q6GYP7-1] uc007nov.2. mouse. [Q6GYP7-2] uc007now.1. mouse. [Q6GYP7-5] uc007nox.2. mouse. [Q6GYP7-4] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 253959. |
Mouse genome database (MGD) from Mouse Genome Informatics (MGI) More...MGIi | MGI:1931050. Ralgapa1. |
Rodent Unidentified Gene-Encoded large proteins database More...Rougei | Search... |
Phylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG3686. Eukaryota. ENOG410XTIX. LUCA. |
Ensembl GeneTree More...GeneTreei | ENSGT00760000119182. |
The HOVERGEN Database of Homologous Vertebrate Genes More...HOVERGENi | HBG051842. |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q6GYP7. |
Identification of Orthologs from Complete Genome Data More...OMAi | CENHDNH. |
Database of Orthologous Groups More...OrthoDBi | EOG091G005P. |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q6GYP7. |
TreeFam database of animal gene trees More...TreeFami | TF324484. |
Miscellaneous databases
Protein Ontology More...PROi | PR:Q6GYP7. |
The Stanford Online Universal Resource for Clones and ESTs More...SOURCEi | Search... |
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSMUSG00000021027. |
CleanEx database of gene expression profiles More...CleanExi | MM_GARNL1. |
ExpressionAtlas, Differential and Baseline Expression More...ExpressionAtlasi | Q6GYP7. baseline and differential. |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q6GYP7. MM. |
Family and domain databases
Gene3D Structural and Functional Annotation of Protein Families More...Gene3Di | 3.40.50.11210. 1 hit. |
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR016024. ARM-type_fold. IPR035974. Rap/Ran-GAP_sf. IPR000331. Rap_GAP_dom. IPR027107. Tuberin/Ral-act_asu. |
The PANTHER Classification System More...PANTHERi | PTHR10063. PTHR10063. 1 hit. |
Pfam protein domain database More...Pfami | View protein in Pfam PF02145. Rap_GAP. 1 hit. |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF111347. SSF111347. 1 hit. SSF48371. SSF48371. 1 hit. |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS50085. RAPGAP. 1 hit. |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | RGPA1_MOUSE | |
| <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | Q6GYP7Primary (citable) accession number: Q6GYP7 Secondary accession number(s): Q6GYP6 , Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4 | |
| <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
| Last sequence update: | July 19, 2004 | |
| Last modified: | March 28, 2018 | |
| This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
| <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
Caution
Was initially thought to act as a transcriptional regulator via its interaction with TCF3/E12.1 Publication
<p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More…</a></p> Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain."
Heng J.I.T., Tan S.-S.
J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1S), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TCF3/E12.