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Protein

Fidgetin-like protein 1

Gene

Fignl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei407 – 4071ATP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi447 – 4526ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fidgetin-like protein 1 (EC:3.6.4.-)
Gene namesi
Name:Fignl1
Synonyms:S30
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1307112. Fignl1.

Subcellular locationi

  • Nucleus By similarity

  • Note: Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Fidgetin-like protein 1PRO_0000302725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6GX84.
PRIDEiQ6GX84.

Expressioni

Inductioni

By E2F1 and serum stimulation.1 Publication

Gene expression databases

BgeeiENSRNOG00000004440.

Interactioni

Subunit structurei

Hexamer. Interacts (via N-terminal one-half region) with RAD51; the interaction is direct. Interacts (via N-terminal one-half region) with SPIDR (via the C-terminal region); the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005857.

Structurei

3D structure databases

ProteinModelPortaliQ6GX84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is necessary for its recruitment to DNA damage sites.By similarity

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000225145.
HOVERGENiHBG061204.
InParanoidiQ6GX84.
OMAiQILRIQY.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ6GX84.
TreeFamiTF105013.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GX84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSSRSVQ VDDWQKNYSV VASSICTPKQ KADAYRALLL HIQDAYANSE
60 70 80 90 100
ISQVFATNLF KRYTEKYSAI IDSDNVVTGL NNYAESIFAL AGSQQADSDK
110 120 130 140 150
WQSGLSINNV FKMSTVQEMM QAGQKFKESL LEPADASVVM CKEPTIFEVP
160 170 180 190 200
QLGVCGGSEE ADLLSSSVHG TEKTQAIPGN SLRCSPFQST LFPMATNTKT
210 220 230 240 250
CLTSSAPSGE STTATFHRTP LFGNTKKEPQ SFPKTSTGLN MFLSNPSCVP
260 270 280 290 300
SGCENPRERK AFNDSDTINM LSNPTLNKAP SKTEDSGQRE DNSLPTFKTA
310 320 330 340 350
KEQLWADQKK RSHQSQHTSK SFNGAIKKSL GAGRSRGIFG KFVPPVSNKQ
360 370 380 390 400
DGSEQNGNVK PKSSRAGSAE PAHLTDDRLK NVEPRMVELI MNEIMDHGPP
410 420 430 440 450
VHWEDIAGVE FAKATIKEIV VWPMMRPDIF TGLRGPPKGI LLFGPPGTGK
460 470 480 490 500
TLIGKCIASQ SGATFFSISA SSLTSKWVGE GEKMVRALFA VARCQQPAVI
510 520 530 540 550
FIDEIDSLLS QRGDGEHESS RRIKTEFLVQ LDGATTSSED RILVVGATNR
560 570 580 590 600
PQEIDEAARR RLVKRLYIPL PEASARKQIV VNLMSKEQCC LTDEETELVV
610 620 630 640 650
QQSDGFSGAD MTQLCREASL GPIRSLHTAD IATISPDQVR PIAYIDFENA
660 670
FRTVRPSVSP KDLELYENWN KTFGCGK
Length:677
Mass (Da):74,197
Last modified:July 19, 2004 - v1
Checksum:i189C08E1509BF4F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623031 mRNA. Translation: AAT46048.1.
AY623032 mRNA. Translation: AAT46049.1.
RefSeqiNP_001011913.1. NM_001011913.1.
XP_006251538.1. XM_006251476.2.
XP_006251539.1. XM_006251477.2.
XP_008768483.1. XM_008770261.1.
UniGeneiRn.211783.

Genome annotation databases

EnsembliENSRNOT00000005857; ENSRNOP00000005857; ENSRNOG00000004440.
GeneIDi289777.
KEGGirno:289777.
UCSCiRGD:1307112. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623031 mRNA. Translation: AAT46048.1.
AY623032 mRNA. Translation: AAT46049.1.
RefSeqiNP_001011913.1. NM_001011913.1.
XP_006251538.1. XM_006251476.2.
XP_006251539.1. XM_006251477.2.
XP_008768483.1. XM_008770261.1.
UniGeneiRn.211783.

3D structure databases

ProteinModelPortaliQ6GX84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005857.

Proteomic databases

PaxDbiQ6GX84.
PRIDEiQ6GX84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005857; ENSRNOP00000005857; ENSRNOG00000004440.
GeneIDi289777.
KEGGirno:289777.
UCSCiRGD:1307112. rat.

Organism-specific databases

CTDi63979.
RGDi1307112. Fignl1.

Phylogenomic databases

eggNOGiKOG0740. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00570000078874.
HOGENOMiHOG000225145.
HOVERGENiHBG061204.
InParanoidiQ6GX84.
OMAiQILRIQY.
OrthoDBiEOG091G0Q8J.
PhylomeDBiQ6GX84.
TreeFamiTF105013.

Miscellaneous databases

PROiQ6GX84.

Gene expression databases

BgeeiENSRNOG00000004440.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIGL1_RAT
AccessioniPrimary (citable) accession number: Q6GX84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.