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Protein

Toll-like receptor 10

Gene

TLR10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-168142 Toll Like Receptor 10 (TLR10) Cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 10
Alternative name(s):
CD_antigen: CD290
Gene namesi
Name:TLR10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:50019 TLR10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 577ExtracellularSequence analysisAdd BLAST558
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 812CytoplasmicSequence analysisAdd BLAST214

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028192720 – 812Toll-like receptor 10Add BLAST793

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6GV17
PRIDEiQ6GV17

Expressioni

Gene expression databases

BgeeiENSBTAG00000014042

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018658

Structurei

3D structure databases

ProteinModelPortaliQ6GV17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 46LRR 1Add BLAST23
Repeati49 – 70LRR 2Add BLAST22
Repeati73 – 94LRR 3Add BLAST22
Repeati97 – 118LRR 4Add BLAST22
Repeati119 – 139LRR 5Add BLAST21
Repeati143 – 166LRR 6Add BLAST24
Repeati296 – 321LRR 7Add BLAST26
Repeati325 – 348LRR 8Add BLAST24
Repeati350 – 373LRR 9Add BLAST24
Repeati374 – 395LRR 10Add BLAST22
Repeati399 – 420LRR 11Add BLAST22
Repeati423 – 443LRR 12Add BLAST21
Repeati445 – 467LRR 13Add BLAST23
Repeati468 – 489LRR 14Add BLAST22
Repeati490 – 510LRR 15Add BLAST21
Domaini523 – 577LRRCTAdd BLAST55
Domaini633 – 779TIRPROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119006
HOGENOMiHOG000008676
HOVERGENiHBG023180
InParanoidiQ6GV17
KOiK10171
OMAiAYLEWPK
OrthoDBiEOG091G0356
TreeFamiTF351113

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027182 TLR10
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF23 PTHR24365:SF23, 1 hit
PfamiView protein in Pfam
PF12799 LRR_4, 1 hit
PF13516 LRR_6, 1 hit
PF13855 LRR_8, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GV17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYIRSIYIF CSIVTSVRSG ASELPEEREL TTNFSSMSLT KVPEGLTPIT
60 70 80 90 100
TTLDLSYNLL FQLQHSDFRS LSKLKVLILC HNRIQELDIK TFEFNKELSY
110 120 130 140 150
LDVSNNRLKS VTWFSLAGLR HLDLSFNDFD TLPISVETGN MSHLETLGLS
160 170 180 190 200
GAKIQKSDFQ KIAHLQLNTV LLGLRTLSHY EEGSLPILNT TRLHIVLPVN
210 220 230 240 250
TNFWVLLHDG IKTSKILEVI NIDLQKSQFT SYESQQIPIL ENAKTSILLL
260 270 280 290 300
NKVDLSWDDL FLIFQLVWHT SVEYFQIQHV TFGGKVYLDH NSFDYSNTVM
310 320 330 340 350
RTIKLEHVHF RIFNIPQESI YLLFTKMDIE NLTISDAQMP HMLFPMYPTR
360 370 380 390 400
FQYLNFANNI LTDDVFKKSI QLPHLKTLIL KDNKLETLSL VSHFASNTSL
410 420 430 440 450
RHLDLSENLL QHENDENCLW PETLVTMNLS FNKFADSVFG CLPRNIQILD
460 470 480 490 500
LNSNKIQTVP KAITHLTSLR ELNLAFNFLT DLPGCSHFRR LLVLNVEMNL
510 520 530 540 550
ILSSSLDFFQ SCQEVKTLNA GRNPFRCTCE LRDFIQLGKY SEGMMVGWSD
560 570 580 590 600
SYICEYPLNL KGTQLKDVHL PEISCNTGLL IVTIVVVMLV LGMAVAFCCL
610 620 630 640 650
HFDLPWYLRM LHQWTQTWLR VRKTTQEQLK RSVQFHVFIS YSEHDSAWVK
660 670 680 690 700
YELIPSLEKE DGSVLICLHE GNSDPGKSMT EDTINCIEKS YKSIFVLSPS
710 720 730 740 750
FVQTEWCHYE PYFAHHNLFH ESLDYIILIL LEPIPLYCIP TRYPELKALM
760 770 780 790 800
EKKAYLEWPK DRRKCGLFWA NLRAALHVNL LDTRGTCELQ TFTELNEGFG
810
GSAISLIRTD CL
Length:812
Mass (Da):93,826
Last modified:January 10, 2006 - v2
Checksum:i0876E0D10119B14C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY634632 mRNA Translation: AAT48490.2
EU006655 Genomic DNA Translation: ABU86944.1
EU006656 Genomic DNA Translation: ABU86945.1
EU006657 Genomic DNA Translation: ABU86946.1
BC123541 mRNA Translation: AAI23542.1
RefSeqiNP_001070386.1, NM_001076918.2
UniGeneiBt.45023

Genome annotation databases

EnsembliENSBTAT00000018658; ENSBTAP00000018658; ENSBTAG00000014042
GeneIDi539791
KEGGibta:539791

Similar proteinsi

Entry informationi

Entry nameiTLR10_BOVIN
AccessioniPrimary (citable) accession number: Q6GV17
Secondary accession number(s): A7YK74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 10, 2006
Last modified: March 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health