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Protein

3-ketodihydrosphingosine reductase

Gene

Kdsr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).1 Publication

Catalytic activityi

Sphinganine + NADP+ = 3-dehydrosphinganine + NADPH.

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei173SubstrateBy similarity1
Active sitei186Proton acceptorPROSITE-ProRule annotation1
Active sitei190Curated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 60NADPCuratedAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • 3-keto-sphinganine metabolic process Source: MGI
  • sphingolipid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.102. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketodihydrosphingosine reductase (EC:1.1.1.102)
Short name:
KDS reductase
Alternative name(s):
3-dehydrosphinganine reductase
Follicular variant translocation protein 1 homolog
Short name:
FVT-1
Gene namesi
Name:Kdsr
Synonyms:Fvt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918000. Kdsr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 270CytoplasmicSequence analysisAdd BLAST245
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 293LumenalSequence analysis2
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 332CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003198326 – 3323-ketodihydrosphingosine reductaseAdd BLAST307

Proteomic databases

EPDiQ6GV12.
PaxDbiQ6GV12.
PRIDEiQ6GV12.

PTM databases

iPTMnetiQ6GV12.
PhosphoSitePlusiQ6GV12.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009905.
CleanExiMM_KDSR.
ExpressionAtlasiQ6GV12. baseline and differential.
GenevisibleiQ6GV12. MM.

Interactioni

Protein-protein interaction databases

BioGridi214234. 1 interactor.
STRINGi10090.ENSMUSP00000010049.

Structurei

3D structure databases

ProteinModelPortaliQ6GV12.
SMRiQ6GV12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1210. Eukaryota.
ENOG410YF8M. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG005757.
InParanoidiQ6GV12.
KOiK04708.
OMAiFERLMAV.
OrthoDBiEOG091G0CEK.
PhylomeDBiQ6GV12.
TreeFamiTF105430.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GV12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLAAAGLV AFVLLLYMVS PLISPKPLAL PGAHVVVTGG SSGIGKCIAI
60 70 80 90 100
ECYKQGAFIT LVARNEDKLL QAKKDIEKHS INDKQVVLCI SVDVSQDYNQ
110 120 130 140 150
VENVIKQAQE KLGPVDMLVN CAGTSMSGKF EELEVSSFEK LMSINYLGSV
160 170 180 190 200
YPSRAVITTM KERRVGRIVF VSSQAGQLGL FGFTAYSSSK FAIRGLAEAL
210 220 230 240 250
QMEVKPYNVY VTVAYPPDTD TPGLAEENKT KPLETRLISE TTAICKPEQV
260 270 280 290 300
AKQIVKDAIQ GNFNSSIGSD GYMLSSLTCG MAPVTSITEG LQQVVTMGLF
310 320 330
RTIALFYLGS FDNIVRRCMV QKAKPEVVDK TA
Length:332
Mass (Da):35,956
Last modified:July 19, 2004 - v1
Checksum:iFBB23BD1C3A3906D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY634684 mRNA. Translation: AAT57900.1.
CCDSiCCDS15210.1.
RefSeqiNP_081810.1. NM_027534.2.
UniGeneiMm.458911.

Genome annotation databases

EnsembliENSMUST00000010049; ENSMUSP00000010049; ENSMUSG00000009905.
GeneIDi70750.
KEGGimmu:70750.
UCSCiuc007cgy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY634684 mRNA. Translation: AAT57900.1.
CCDSiCCDS15210.1.
RefSeqiNP_081810.1. NM_027534.2.
UniGeneiMm.458911.

3D structure databases

ProteinModelPortaliQ6GV12.
SMRiQ6GV12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214234. 1 interactor.
STRINGi10090.ENSMUSP00000010049.

PTM databases

iPTMnetiQ6GV12.
PhosphoSitePlusiQ6GV12.

Proteomic databases

EPDiQ6GV12.
PaxDbiQ6GV12.
PRIDEiQ6GV12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010049; ENSMUSP00000010049; ENSMUSG00000009905.
GeneIDi70750.
KEGGimmu:70750.
UCSCiuc007cgy.2. mouse.

Organism-specific databases

CTDi2531.
MGIiMGI:1918000. Kdsr.

Phylogenomic databases

eggNOGiKOG1210. Eukaryota.
ENOG410YF8M. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG005757.
InParanoidiQ6GV12.
KOiK04708.
OMAiFERLMAV.
OrthoDBiEOG091G0CEK.
PhylomeDBiQ6GV12.
TreeFamiTF105430.

Enzyme and pathway databases

UniPathwayiUPA00222.
BRENDAi1.1.1.102. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiKdsr. mouse.
PROiQ6GV12.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009905.
CleanExiMM_KDSR.
ExpressionAtlasiQ6GV12. baseline and differential.
GenevisibleiQ6GV12. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDSR_MOUSE
AccessioniPrimary (citable) accession number: Q6GV12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.