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Q6GUR1 (CP1A1_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:CYP1A1
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Cytochrome P450 1A1
PRO_0000051629

Sites

Metal binding4571Iron (heme axial ligand) By similarity
Binding site2241Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GUR1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 6E2CE95F04197739

FASTA51258,129
        10         20         30         40         50         60 
MLFRISMSAT EFLLASLIFC LVFWVIRASR PRVPKGLKNP PGPWGWPLIG HILTLGKNPH 

        70         80         90        100        110        120 
LALSRMSQRY GDVLQIRIGS TPVLVLSGLD TIRQALVQQG DDFKGRPNLY SFTLISNGQS 

       130        140        150        160        170        180 
MSFGPDSGPV WAARRRLAQN GLKSFSIASD PASSSSCYLE EHVSKEAEVL ISKLQEQMAG 

       190        200        210        220        230        240 
PGHFNPYRYV VISVANVICA ICFGQRYDHN HQELLSLVNL SNNFGEVVGS GNPADFIPIL 

       250        260        270        280        290        300 
RYLPNRSLNG FKDLNEKFHS FMQKMIKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANI 

       310        320        330        340        350        360 
QLSDEKIVNV VLDLFGAGFD TVTTAISWSL MYLVTNPRVQ RKIQEELDTV IGRSRRPRLS 

       370        380        390        400        410        420 
DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL 

       430        440        450        460        470        480 
WVNPSEFLPE RFITPDGAID KVLSEKVILF GLGKRKCIGE TIARWEVFLF LAILLQRVEF 

       490        500        510 
SVPPGVKVDM TPIYGLTMKH ACCEHFQMQL RS 

« Hide

References

[1]"Cloning of rhesus monkey cytochrome P450 1A1 (CYP1A1)."
Carr B.A., Fang Y., Rushmore T.H.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY635458 mRNA. Translation: AAT49262.1.
RefSeqNP_001035328.1. NM_001040238.1.
UniGeneMmu.3773.

3D structure databases

ProteinModelPortalQ6GUR1.
SMRQ6GUR1. Positions 32-509.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000029575.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000031615; ENSMMUP00000029575; ENSMMUG00000022481.
GeneID678694.
KEGGmcc:678694.

Organism-specific databases

CTD1543.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117317.
HOGENOMHOG000036991.
HOVERGENHBG106944.
InParanoidQ6GUR1.
KOK07408.
OMAHLPYMEA.
OrthoDBEOG7RBZ85.
TreeFamTF105095.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19981126.

Entry information

Entry nameCP1A1_MACMU
AccessionPrimary (citable) accession number: Q6GUR1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families