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Q6GUR1

- CP1A1_MACMU

UniProt

Q6GUR1 - CP1A1_MACMU

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Protein

Cytochrome P450 1A1

Gene
CYP1A1
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241Substrate By similarity
Metal bindingi457 – 4571Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. vitamin D 24-hydroxylase activity Source: Ensembl

GO - Biological processi

  1. amine metabolic process Source: Ensembl
  2. drug metabolic process Source: Ensembl
  3. heterocycle metabolic process Source: Ensembl
  4. hydrogen peroxide biosynthetic process Source: Ensembl
  5. response to toxic substance Source: Ensembl
  6. toxin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:CYP1A1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome P450 1A1PRO_0000051629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000029575.

Structurei

3D structure databases

ProteinModelPortaliQ6GUR1.
SMRiQ6GUR1. Positions 32-509.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117317.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ6GUR1.
KOiK07408.
OMAiHLPYMEA.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GUR1-1 [UniParc]FASTAAdd to Basket

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MLFRISMSAT EFLLASLIFC LVFWVIRASR PRVPKGLKNP PGPWGWPLIG    50
HILTLGKNPH LALSRMSQRY GDVLQIRIGS TPVLVLSGLD TIRQALVQQG 100
DDFKGRPNLY SFTLISNGQS MSFGPDSGPV WAARRRLAQN GLKSFSIASD 150
PASSSSCYLE EHVSKEAEVL ISKLQEQMAG PGHFNPYRYV VISVANVICA 200
ICFGQRYDHN HQELLSLVNL SNNFGEVVGS GNPADFIPIL RYLPNRSLNG 250
FKDLNEKFHS FMQKMIKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANI 300
QLSDEKIVNV VLDLFGAGFD TVTTAISWSL MYLVTNPRVQ RKIQEELDTV 350
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY 400
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFITPDGAID KVLSEKVILF 450
GLGKRKCIGE TIARWEVFLF LAILLQRVEF SVPPGVKVDM TPIYGLTMKH 500
ACCEHFQMQL RS 512
Length:512
Mass (Da):58,129
Last modified:July 19, 2004 - v1
Checksum:i6E2CE95F04197739
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY635458 mRNA. Translation: AAT49262.1.
RefSeqiNP_001035328.1. NM_001040238.1.
UniGeneiMmu.3773.

Genome annotation databases

EnsembliENSMMUT00000031615; ENSMMUP00000029575; ENSMMUG00000022481.
GeneIDi678694.
KEGGimcc:678694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY635458 mRNA. Translation: AAT49262.1 .
RefSeqi NP_001035328.1. NM_001040238.1.
UniGenei Mmu.3773.

3D structure databases

ProteinModelPortali Q6GUR1.
SMRi Q6GUR1. Positions 32-509.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000029575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000031615 ; ENSMMUP00000029575 ; ENSMMUG00000022481 .
GeneIDi 678694.
KEGGi mcc:678694.

Organism-specific databases

CTDi 1543.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117317.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi Q6GUR1.
KOi K07408.
OMAi HLPYMEA.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Miscellaneous databases

NextBioi 19981126.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of rhesus monkey cytochrome P450 1A1 (CYP1A1)."
    Carr B.A., Fang Y., Rushmore T.H.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP1A1_MACMU
AccessioniPrimary (citable) accession number: Q6GUR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3