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Q6GUR1

- CP1A1_MACMU

UniProt

Q6GUR1 - CP1A1_MACMU

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241SubstrateBy similarity
    Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. vitamin D 24-hydroxylase activity Source: Ensembl

    GO - Biological processi

    1. amine metabolic process Source: Ensembl
    2. drug metabolic process Source: Ensembl
    3. heterocycle metabolic process Source: Ensembl
    4. hydrogen peroxide biosynthetic process Source: Ensembl
    5. response to toxic substance Source: Ensembl
    6. toxin metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:CYP1A1
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Cytochrome P450 1A1PRO_0000051629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000029575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GUR1.
    SMRiQ6GUR1. Positions 32-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117317.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiQ6GUR1.
    KOiK07408.
    OMAiHLPYMEA.
    OrthoDBiEOG7RBZ85.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GUR1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFRISMSAT EFLLASLIFC LVFWVIRASR PRVPKGLKNP PGPWGWPLIG    50
    HILTLGKNPH LALSRMSQRY GDVLQIRIGS TPVLVLSGLD TIRQALVQQG 100
    DDFKGRPNLY SFTLISNGQS MSFGPDSGPV WAARRRLAQN GLKSFSIASD 150
    PASSSSCYLE EHVSKEAEVL ISKLQEQMAG PGHFNPYRYV VISVANVICA 200
    ICFGQRYDHN HQELLSLVNL SNNFGEVVGS GNPADFIPIL RYLPNRSLNG 250
    FKDLNEKFHS FMQKMIKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANI 300
    QLSDEKIVNV VLDLFGAGFD TVTTAISWSL MYLVTNPRVQ RKIQEELDTV 350
    IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY 400
    IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFITPDGAID KVLSEKVILF 450
    GLGKRKCIGE TIARWEVFLF LAILLQRVEF SVPPGVKVDM TPIYGLTMKH 500
    ACCEHFQMQL RS 512
    Length:512
    Mass (Da):58,129
    Last modified:July 19, 2004 - v1
    Checksum:i6E2CE95F04197739
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY635458 mRNA. Translation: AAT49262.1.
    RefSeqiNP_001035328.1. NM_001040238.1.
    UniGeneiMmu.3773.

    Genome annotation databases

    EnsembliENSMMUT00000031615; ENSMMUP00000029575; ENSMMUG00000022481.
    GeneIDi678694.
    KEGGimcc:678694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY635458 mRNA. Translation: AAT49262.1 .
    RefSeqi NP_001035328.1. NM_001040238.1.
    UniGenei Mmu.3773.

    3D structure databases

    ProteinModelPortali Q6GUR1.
    SMRi Q6GUR1. Positions 32-509.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000029575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000031615 ; ENSMMUP00000029575 ; ENSMMUG00000022481 .
    GeneIDi 678694.
    KEGGi mcc:678694.

    Organism-specific databases

    CTDi 1543.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117317.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi Q6GUR1.
    KOi K07408.
    OMAi HLPYMEA.
    OrthoDBi EOG7RBZ85.
    TreeFami TF105095.

    Miscellaneous databases

    NextBioi 19981126.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of rhesus monkey cytochrome P450 1A1 (CYP1A1)."
      Carr B.A., Fang Y., Rushmore T.H.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP1A1_MACMU
    AccessioniPrimary (citable) accession number: Q6GUR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3