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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224SubstrateBy similarity1
Metal bindingi457Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:CYP1A1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516291 – 512Cytochrome P450 1A1Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000022481.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000029575.

Structurei

3D structure databases

ProteinModelPortaliQ6GUR1.
SMRiQ6GUR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137854.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ6GUR1.
KOiK07408.
OMAiNNWQDYI.
OrthoDBiEOG091G0BT8.
TreeFamiTF105095.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GUR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRISMSAT EFLLASLIFC LVFWVIRASR PRVPKGLKNP PGPWGWPLIG
60 70 80 90 100
HILTLGKNPH LALSRMSQRY GDVLQIRIGS TPVLVLSGLD TIRQALVQQG
110 120 130 140 150
DDFKGRPNLY SFTLISNGQS MSFGPDSGPV WAARRRLAQN GLKSFSIASD
160 170 180 190 200
PASSSSCYLE EHVSKEAEVL ISKLQEQMAG PGHFNPYRYV VISVANVICA
210 220 230 240 250
ICFGQRYDHN HQELLSLVNL SNNFGEVVGS GNPADFIPIL RYLPNRSLNG
260 270 280 290 300
FKDLNEKFHS FMQKMIKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANI
310 320 330 340 350
QLSDEKIVNV VLDLFGAGFD TVTTAISWSL MYLVTNPRVQ RKIQEELDTV
360 370 380 390 400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY
410 420 430 440 450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFITPDGAID KVLSEKVILF
460 470 480 490 500
GLGKRKCIGE TIARWEVFLF LAILLQRVEF SVPPGVKVDM TPIYGLTMKH
510
ACCEHFQMQL RS
Length:512
Mass (Da):58,129
Last modified:July 19, 2004 - v1
Checksum:i6E2CE95F04197739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635458 mRNA. Translation: AAT49262.1.
RefSeqiNP_001035328.1. NM_001040238.1.
XP_014998188.1. XM_015142702.1.
XP_014998189.1. XM_015142703.1.
UniGeneiMmu.3773.

Genome annotation databases

EnsembliENSMMUT00000031615; ENSMMUP00000029575; ENSMMUG00000022481.
GeneIDi678694.
KEGGimcc:678694.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCP1A1_MACMU
AccessioniPrimary (citable) accession number: Q6GUR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 19, 2004
Last modified: July 5, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families