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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Gene namesi
Name:CYP2E1
Synonyms:CYP2E
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517531 – 493Cytochrome P450 2E1Add BLAST493

Expressioni

Inductioni

By ethanol.

Structurei

3D structure databases

ProteinModelPortaliQ6GUQ4.
SMRiQ6GUQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 303Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiQ6GUQ4.
KOiK07415.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GUQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALGVSVAL LVWVAVLLLV SIWRQVHSSW NLPPGPFPLP IIGNLFQLEL
60 70 80 90 100
KNIPKSFTRL AQRFGPVFTL YVGSRRVVVV HGYKAVREVL LDHKDEFSGR
110 120 130 140 150
GDIPAFHAHR DRGIIFNNGP TWKDIRRFSL TTLRNYGMGK QGNESRIQRE
160 170 180 190 200
AHFLLEALRK TQGQPFDPTF LIGCAPCNVI ADILFRKHFD YNDEKFLRLM
210 220 230 240 250
YLFNENFQLL STPWLQLYNN FPSLLHYLPG SHRKVMKNVA EIKEYVSERV
260 270 280 290 300
KEHLQSLDPN CPRDLTDCLL VEMEKEKHSA ERLYTMDGIT VTVADLFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRIPA IKDRQEMPYM
360 370 380 390 400
DAVVHEIQRF ITLVPSNLPH EATRDTIFRG YIIPKGTVIV PTLDSVLYDN
410 420 430 440 450
QEFPDPEKFK PEHFLDESGK FKYSDYFKPF SAGKRVCAGE GLARMELFLL
460 470 480 490
LSAILQHFNL KPLVDPKDID ISPVNIGFGC IPPRFKLCVI PRS
Length:493
Mass (Da):56,645
Last modified:July 19, 2004 - v1
Checksum:i758075CB234AF5A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635465 mRNA. Translation: AAT49269.1.
RefSeqiNP_001035303.1. NM_001040213.1.
UniGeneiMmu.3777.

Genome annotation databases

GeneIDi678688.
KEGGimcc:678688.

Similar proteinsi

Entry informationi

Entry nameiCP2E1_MACMU
AccessioniPrimary (citable) accession number: Q6GUQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 19, 2004
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families