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Protein

P2Y purinoceptor 13

Gene

P2ry13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.1 Publication

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417957. P2Y receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 13
Short name:
P2Y13
Gene namesi
Name:P2ry13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1302941. P2ry13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 607CytoplasmicSequence analysis
Transmembranei61 – 8121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini82 – 10019ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini122 – 14423CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 19328ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini215 – 23723CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 28123ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 33634CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336P2Y purinoceptor 13PRO_0000070043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6GUG4.
PRIDEiQ6GUG4.

PTM databases

PhosphoSiteiQ6GUG4.

Expressioni

Tissue specificityi

Highest levels in spleen, liver brain and kidney. Lower but significant level are also detected in intestine, stomach, skeletal muscle, testis, heart and lung.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047532.

Structurei

3D structure databases

ProteinModelPortaliQ6GUG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFYD. Eukaryota.
ENOG410ZJD1. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ6GUG4.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ6GUG4.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GUG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTVNTTGM QGFNKSERCP RDTRMTQLLF PVLYTVVFFT GVLLNTLALW
60 70 80 90 100
VFIHIPSNST FIIYLKNTLV ADLIMTLMLP FKILSDSRLA PWQLRGFVCT
110 120 130 140 150
FSSVVFYETM YVGIMMLGLI AFDRFLKIVV PFRKTFVKKT AFAKIVSISI
160 170 180 190 200
WLLMFLISLP NMILNKEATA STVKKCASLK SPLGLLWHQV VSHTCQFIFW
210 220 230 240 250
TVFILMLLFY TVIAKKVYDS YRKFKSRDSK HKRLEAKVFI VMAVFFVCFA
260 270 280 290 300
PFHFVRVPYT HSQTTNKTDC RLENQLFLAK ESTLFLATTN ICMDPLIYII
310 320 330
LCKKFTRKVP CMRWRTKTAA SSDEHHSSQT DNITLS
Length:336
Mass (Da):38,823
Last modified:July 19, 2004 - v1
Checksum:iE1DA0D314DD8C1CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY639875 mRNA. Translation: AAT57664.1.
RefSeqiNP_001002853.1. NM_001002853.1.
XP_008759213.1. XM_008760991.1.
UniGeneiRn.209780.

Genome annotation databases

EnsembliENSRNOT00000051027; ENSRNOP00000047532; ENSRNOG00000029756.
GeneIDi310444.
KEGGirno:310444.
UCSCiRGD:1302941. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY639875 mRNA. Translation: AAT57664.1.
RefSeqiNP_001002853.1. NM_001002853.1.
XP_008759213.1. XM_008760991.1.
UniGeneiRn.209780.

3D structure databases

ProteinModelPortaliQ6GUG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047532.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6GUG4.

Proteomic databases

PaxDbiQ6GUG4.
PRIDEiQ6GUG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000051027; ENSRNOP00000047532; ENSRNOG00000029756.
GeneIDi310444.
KEGGirno:310444.
UCSCiRGD:1302941. rat.

Organism-specific databases

CTDi53829.
RGDi1302941. P2ry13.

Phylogenomic databases

eggNOGiENOG410IFYD. Eukaryota.
ENOG410ZJD1. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ6GUG4.
KOiK08388.
OMAiFYVVIAK.
OrthoDBiEOG7JQBNQ.
PhylomeDBiQ6GUG4.
TreeFamiTF330969.

Enzyme and pathway databases

ReactomeiR-RNO-417957. P2Y receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ6GUG4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008109. P2Y13_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01735. P2Y13PRNCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor."
    Fumagalli M., Trincavelli L., Lecca D., Martini C., Ciana P., Abbracchio M.P.
    Biochem. Pharmacol. 68:113-124(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiP2Y13_RAT
AccessioniPrimary (citable) accession number: Q6GUG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 19, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.