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Protein

P2Y purinoceptor 13

Gene

P2ry13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.1 Publication

GO - Molecular functioni

  • G-protein coupled purinergic nucleotide receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417957 P2Y receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 13
Short name:
P2Y13
Gene namesi
Name:P2ry13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1302941 P2ry13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 60CytoplasmicSequence analysis7
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 100ExtracellularSequence analysisAdd BLAST19
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 144CytoplasmicSequence analysisAdd BLAST23
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 193ExtracellularSequence analysisAdd BLAST28
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 237CytoplasmicSequence analysisAdd BLAST23
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 281ExtracellularSequence analysisAdd BLAST23
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 336CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700431 – 336P2Y purinoceptor 13Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6GUG4
PRIDEiQ6GUG4

PTM databases

PhosphoSitePlusiQ6GUG4

Expressioni

Tissue specificityi

Highest levels in spleen, liver brain and kidney. Lower but significant level are also detected in intestine, stomach, skeletal muscle, testis, heart and lung.1 Publication

Gene expression databases

BgeeiENSRNOG00000029756

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047532

Structurei

3D structure databases

ProteinModelPortaliQ6GUG4
SMRiQ6GUG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFYD Eukaryota
ENOG410ZJD1 LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000273884
HOVERGENiHBG108228
InParanoidiQ6GUG4
KOiK08388
OMAiFYVVIAK
OrthoDBiEOG091G0ALN
PhylomeDBiQ6GUG4
TreeFamiTF330969

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008109 P2Y13_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01735 P2Y13PRNCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GUG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTVNTTGM QGFNKSERCP RDTRMTQLLF PVLYTVVFFT GVLLNTLALW
60 70 80 90 100
VFIHIPSNST FIIYLKNTLV ADLIMTLMLP FKILSDSRLA PWQLRGFVCT
110 120 130 140 150
FSSVVFYETM YVGIMMLGLI AFDRFLKIVV PFRKTFVKKT AFAKIVSISI
160 170 180 190 200
WLLMFLISLP NMILNKEATA STVKKCASLK SPLGLLWHQV VSHTCQFIFW
210 220 230 240 250
TVFILMLLFY TVIAKKVYDS YRKFKSRDSK HKRLEAKVFI VMAVFFVCFA
260 270 280 290 300
PFHFVRVPYT HSQTTNKTDC RLENQLFLAK ESTLFLATTN ICMDPLIYII
310 320 330
LCKKFTRKVP CMRWRTKTAA SSDEHHSSQT DNITLS
Length:336
Mass (Da):38,823
Last modified:July 19, 2004 - v1
Checksum:iE1DA0D314DD8C1CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY639875 mRNA Translation: AAT57664.1
RefSeqiNP_001002853.1, NM_001002853.1
XP_008759213.1, XM_008760991.2
UniGeneiRn.209780

Genome annotation databases

EnsembliENSRNOT00000051027; ENSRNOP00000047532; ENSRNOG00000029756
GeneIDi310444
KEGGirno:310444
UCSCiRGD:1302941 rat

Similar proteinsi

Entry informationi

Entry nameiP2Y13_RAT
AccessioniPrimary (citable) accession number: Q6GUG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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