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Q6GU14

- Q6GU14_MOUSE

UniProt

Q6GU14 - Q6GU14_MOUSE

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Protein
Submitted name:

Peroxisome proliferator activated receptor gamma

Gene
Pparg
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. drug binding Source: Ensembl
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  5. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  6. protein binding Source: MGI
  7. RNA polymerase II regulatory region DNA binding Source: MGI
  8. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  9. sequence-specific DNA binding Source: InterPro
  10. sequence-specific DNA binding transcription factor activity Source: MGI
  11. steroid hormone receptor activity Source: InterPro
  12. zinc ion binding Source: InterPro

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. brown fat cell differentiation Source: MGI
  3. cell fate commitment Source: MGI
  4. cell maturation Source: Ensembl
  5. cellular response to insulin stimulus Source: Ensembl
  6. cellular response to lithium ion Source: MGI
  7. cellular response to organic cyclic compound Source: MGI
  8. epithelial cell differentiation Source: MGI
  9. fat cell differentiation Source: MGI
  10. fatty acid oxidation Source: Ensembl
  11. glucose homeostasis Source: Ensembl
  12. heart development Source: Ensembl
  13. inflammatory response Source: MGI
  14. lipoprotein transport Source: Ensembl
  15. long-chain fatty acid transport Source: MGI
  16. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
  17. monocyte differentiation Source: Ensembl
  18. negative regulation of acute inflammatory response Source: Ensembl
  19. negative regulation of cell growth Source: Ensembl
  20. negative regulation of cell proliferation Source: MGI
  21. negative regulation of cholesterol storage Source: Ensembl
  22. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
  23. negative regulation of receptor biosynthetic process Source: Ensembl
  24. negative regulation of sequestering of triglyceride Source: Ensembl
  25. negative regulation of smooth muscle cell proliferation Source: Ensembl
  26. negative regulation of telomerase activity Source: Ensembl
  27. negative regulation of transcription, DNA-templated Source: MGI
  28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  29. organ regeneration Source: Ensembl
  30. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
  31. placenta development Source: MGI
  32. positive regulation of fat cell differentiation Source: MGI
  33. positive regulation of fatty acid oxidation Source: Ensembl
  34. positive regulation of oligodendrocyte differentiation Source: Ensembl
  35. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  36. positive regulation of transcription, DNA-templated Source: MGI
  37. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  38. regulation of blood pressure Source: Ensembl
  39. regulation of fat cell differentiation Source: MGI
  40. response to caffeine Source: Ensembl
  41. response to cold Source: Ensembl
  42. response to drug Source: Ensembl
  43. response to estrogen Source: Ensembl
  44. response to low-density lipoprotein particle Source: Ensembl
  45. response to retinoic acid Source: Ensembl
  46. response to vitamin A Source: Ensembl
  47. white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activated receptor gammaImported
Submitted name:
Peroxisome proliferator-activated receptor gammaImported
Submitted name:
Peroxisome proliferator-activated receptor gamma isoform 2Imported
Submitted name:
Peroxisome proliferator-activated receptor gamma transcript 2Imported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:97747. Pparg.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ6GU14.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115076.
HOVERGENiHBG106004.
InParanoidiQ6GU14.
KOiK08530.
OMAiSTPHYED.
OrthoDBiEOG7X9G7F.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR022590. PPARgamma_N.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GU14-1 [UniParc]FASTAAdd to Basket

« Hide

MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL    50
SVMEDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ 100
EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH 150
YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA 200
VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY 250
IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 300
QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV 350
HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV 400
KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK 450
LNHPESSQLF AKVLQKMTDL RQIVTEHVQL LHVIKKTETD MSLHPLLQEI 500
YKDLY 505
Length:505
Mass (Da):57,571
Last modified:May 10, 2005 - v1
Checksum:iBA7F33909BE2A10A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC153828 Genomic DNA. No translation available.
AC171970 Genomic DNA. No translation available.
BC021798 mRNA. Translation: AAH21798.1.
AY208183 mRNA. Translation: AAO45097.1.
AY208184 mRNA. Translation: AAO45098.1.
AY243585 mRNA. Translation: AAP42200.1.
AB256529 Genomic DNA. Translation: BAF80899.1.
AB256530 Genomic DNA. Translation: BAF80900.1.
RefSeqiNP_035276.2. NM_011146.3.
UniGeneiMm.3020.

Genome annotation databases

EnsembliENSMUST00000000450; ENSMUSP00000000450; ENSMUSG00000000440.
GeneIDi19016.
KEGGimmu:19016.
UCSCiuc009dis.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC153828 Genomic DNA. No translation available.
AC171970 Genomic DNA. No translation available.
BC021798 mRNA. Translation: AAH21798.1 .
AY208183 mRNA. Translation: AAO45097.1 .
AY208184 mRNA. Translation: AAO45098.1 .
AY243585 mRNA. Translation: AAP42200.1 .
AB256529 Genomic DNA. Translation: BAF80899.1 .
AB256530 Genomic DNA. Translation: BAF80900.1 .
RefSeqi NP_035276.2. NM_011146.3.
UniGenei Mm.3020.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000450 ; ENSMUSP00000000450 ; ENSMUSG00000000440 .
GeneIDi 19016.
KEGGi mmu:19016.
UCSCi uc009dis.2. mouse.

Organism-specific databases

CTDi 5468.
MGIi MGI:97747. Pparg.

Phylogenomic databases

GeneTreei ENSGT00740000115076.
HOVERGENi HBG106004.
InParanoidi Q6GU14.
KOi K08530.
OMAi STPHYED.
OrthoDBi EOG7X9G7F.
TreeFami TF316304.

Miscellaneous databases

NextBioi 295444.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6GU14.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR022590. PPARgamma_N.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice."
    Lyons M.A., Wittenburg H., Li R., Walsh K.A., Churchill G.A., Carey M.C., Paigen B.
    J. Lipid Res. 44:953-967(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CAST/EiImported and DBA/2JImported.
    Tissue: LiverImported.
  2. "New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice."
    Lyons M.A., Wittenburg H., Li R., Walsh K.A., Leonard M.R., Churchill G.A., Carey M.C., Paigen B.
    Physiol. Genomics 14:225-239(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129S1/SvImJImported.
    Tissue: LiverImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Salivary glandImported.
  4. "Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes."
    Babaya M., Ikegami H., Fujisawa T.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/HeImported and NSYImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6GU14_MOUSE
AccessioniPrimary (citable) accession number: Q6GU14
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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