Q6GU14 (Q6GU14_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Peroxisome proliferator activated receptor gamma EMBL AAH21798.1

Submitted name:
Peroxisome proliferator-activated receptor gamma Ensembl ENSMUSP00000000450 EMBL BAF80899.1
Submitted name:
Peroxisome proliferator-activated receptor gamma isoform 2 EMBL AAO45097.1
Submitted name:
Peroxisome proliferator-activated receptor gamma transcript 2 EMBL AAP42200.1

Gene names

Name:

Pparg EMBL AAO45097.1 Ensembl ENSMUSP00000000450 MGI 97747

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS000536 RuleBase RU004334
Cellular component	Nucleus SAAS SAAS000536 RuleBase RU004334
Domain	Zinc-finger SAAS SAAS000536 RuleBase RU004334
Ligand	DNA-binding SAAS SAAS000536 RuleBase RU004334 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL AAH21798.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara brown fat cell differentiation Inferred from direct assay PubMed 18492766. Source: MGI cell fate commitment Inferred from genetic interaction PubMed 15687259. Source: MGI cell maturation Inferred from electronic annotation. Source: Compara cellular response to insulin stimulus Inferred from electronic annotation. Source: Compara cellular response to lithium ion Inferred from direct assay PubMed 15673614. Source: MGI cellular response to organic cyclic compound Inferred from direct assay PubMed 12055200. Source: MGI epithelial cell differentiation Inferred from genetic interaction PubMed 15687259. Source: MGI fatty acid oxidation Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara inflammatory response Traceable author statement PubMed 12163159. Source: MGI lipoprotein transport Inferred from electronic annotation. Source: Compara long-chain fatty acid transport Inferred from mutant phenotype PubMed 17463056. Source: MGI low-density lipoprotein particle receptor biosynthetic process Inferred from electronic annotation. Source: Compara monocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of acute inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from mutant phenotype PubMed 12370429. Source: MGI negative regulation of cholesterol storage Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of receptor biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of sequestering of triglyceride Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of telomerase activity Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 8041794. Source: MGI organ regeneration Inferred from electronic annotation. Source: Compara peroxisome proliferator activated receptor signaling pathway Inferred from electronic annotation. Source: Compara placenta development Inferred from mutant phenotype PubMed 17463056. Source: MGI positive regulation of fat cell differentiation Inferred from direct assay PubMed 10937998PubMed 15175325PubMed 15728361. Source: MGI positive regulation of fatty acid oxidation Inferred from electronic annotation. Source: Compara positive regulation of oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 12037571PubMed 16099986. Source: MGI regulation of blood pressure Inferred from electronic annotation. Source: Compara response to caffeine Inferred from electronic annotation. Source: Compara response to cold Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to low-density lipoprotein particle stimulus Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara response to vitamin A Inferred from electronic annotation. Source: Compara white fat cell differentiation Inferred from direct assay PubMed 18492766. Source: MGI
Cellular_component	cytosol Inferred from direct assay PubMed 12163159PubMed 15164767. Source: MGI nucleus Inferred from direct assay PubMed 12163159PubMed 15164767PubMed 21669876. Source: MGI
Molecular_function	RNA polymerase II regulatory region DNA binding Inferred from direct assay PubMed 15175325. Source: MGI chromatin binding Inferred from direct assay PubMed 19066220. Source: MGI drug binding Inferred from electronic annotation. Source: Compara ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Traceable author statement PubMed 12163159. Source: MGI ligand-dependent nuclear receptor transcription coactivator activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6GU14 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: BA7F33909BE2A10A	FASTA	505	57,571
	10 20 30 40 50 60 MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 70 80 90 100 110 120 DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 130 140 150 160 170 180 QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC 190 200 210 220 230 240 RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR 250 260 270 280 290 300 ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 310 320 330 340 350 360 QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS 370 380 390 400 410 420 LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII 430 440 450 460 470 480 LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL 490 500 LHVIKKTETD MSLHPLLQEI YKDLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice." Lyons M.A., Wittenburg H., Li R., Walsh K.A., Churchill G.A., Carey M.C., Paigen B. J. Lipid Res. 44:953-967(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CAST/Ei EMBL AAO45097.1 and DBA/2J EMBL AAO45098.1. Tissue: Liver EMBL AAO45097.1.
[2]	"New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice." Lyons M.A., Wittenburg H., Li R., Walsh K.A., Leonard M.R., Churchill G.A., Carey M.C., Paigen B. Physiol. Genomics 14:225-239(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129S1/SvImJ EMBL AAP42200.1. Tissue: Liver EMBL AAP42200.1.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N EMBL AAH21798.1. Tissue: Salivary gland EMBL AAH21798.1.
[4]	"Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes." Babaya M., Ikegami H., Fujisawa T. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C3H/He EMBL BAF80900.1 and NSY EMBL BAF80899.1.
[5]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000000450.
[6]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000000450.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC153828 Genomic DNA. No translation available. AC171970 Genomic DNA. No translation available. BC021798 mRNA. Translation: AAH21798.1. AY208183 mRNA. Translation: AAO45097.1. AY208184 mRNA. Translation: AAO45098.1. AY243585 mRNA. Translation: AAP42200.1. AB256529 Genomic DNA. Translation: BAF80899.1. AB256530 Genomic DNA. Translation: BAF80900.1.
IPI	IPI00266075.
RefSeq	NP_035276.2. NM_011146.3.
UniGene	Mm.3020.
3D structure databases
SMR	Q6GU14. Positions 135-505.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000450; ENSMUSP00000000450; ENSMUSG00000000440.
GeneID	19016.
KEGG	mmu:19016.
UCSC	uc009dis.2. mouse.
Organism-specific databases
CTD	5468.
MGI	MGI:97747. Pparg.
Phylogenomic databases
GeneTree	ENSGT00700000104361.
HOVERGEN	HBG106004.
InParanoid	Q6GU14.
KO	K08530.
OMA	KTTDKSP.
Gene expression databases
Genevestigator	Q6GU14.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR003074. 1Cnucl_rcpt. IPR003077. 1Cnucl_rcpt_G. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR022590. PPARgamma_N. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF12577. PPARgamma_N. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01288. PROXISOMEPAR. PR01291. PROXISOMPAGR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	295444.
SOURCE	Search...

Entry information

Entry name

Q6GU14_MOUSE

Accession

Primary (citable) accession number: Q6GU14

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)