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Q6GU14

- Q6GU14_MOUSE

UniProt

Q6GU14 - Q6GU14_MOUSE

Protein
Submitted name:

Peroxisome proliferator activated receptor gamma

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. drug binding Source: Ensembl
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    5. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    6. protein binding Source: MGI
    7. RNA polymerase II regulatory region DNA binding Source: MGI
    8. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    9. sequence-specific DNA binding Source: InterPro
    10. sequence-specific DNA binding transcription factor activity Source: MGI
    11. steroid hormone receptor activity Source: InterPro
    12. zinc ion binding Source: InterPro

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. brown fat cell differentiation Source: MGI
    3. cell fate commitment Source: MGI
    4. cell maturation Source: Ensembl
    5. cellular response to insulin stimulus Source: Ensembl
    6. cellular response to lithium ion Source: MGI
    7. cellular response to organic cyclic compound Source: MGI
    8. epithelial cell differentiation Source: MGI
    9. fat cell differentiation Source: MGI
    10. fatty acid oxidation Source: Ensembl
    11. glucose homeostasis Source: Ensembl
    12. heart development Source: Ensembl
    13. inflammatory response Source: MGI
    14. lipoprotein transport Source: Ensembl
    15. long-chain fatty acid transport Source: MGI
    16. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
    17. monocyte differentiation Source: Ensembl
    18. negative regulation of acute inflammatory response Source: Ensembl
    19. negative regulation of cell growth Source: Ensembl
    20. negative regulation of cell proliferation Source: MGI
    21. negative regulation of cholesterol storage Source: Ensembl
    22. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
    23. negative regulation of receptor biosynthetic process Source: Ensembl
    24. negative regulation of sequestering of triglyceride Source: Ensembl
    25. negative regulation of smooth muscle cell proliferation Source: Ensembl
    26. negative regulation of telomerase activity Source: Ensembl
    27. negative regulation of transcription, DNA-templated Source: MGI
    28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    29. organ regeneration Source: Ensembl
    30. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
    31. placenta development Source: MGI
    32. positive regulation of fat cell differentiation Source: MGI
    33. positive regulation of fatty acid oxidation Source: Ensembl
    34. positive regulation of oligodendrocyte differentiation Source: Ensembl
    35. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    36. positive regulation of transcription, DNA-templated Source: MGI
    37. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    38. regulation of blood pressure Source: Ensembl
    39. regulation of fat cell differentiation Source: MGI
    40. response to caffeine Source: Ensembl
    41. response to cold Source: Ensembl
    42. response to drug Source: Ensembl
    43. response to estrogen Source: Ensembl
    44. response to low-density lipoprotein particle Source: Ensembl
    45. response to retinoic acid Source: Ensembl
    46. response to vitamin A Source: Ensembl
    47. white fat cell differentiation Source: MGI

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome proliferator activated receptor gammaImported
    Submitted name:
    Peroxisome proliferator-activated receptor gammaImported
    Submitted name:
    Peroxisome proliferator-activated receptor gamma isoform 2Imported
    Submitted name:
    Peroxisome proliferator-activated receptor gamma transcript 2Imported
    Gene namesi
    Name:PpargImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:97747. Pparg.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ6GU14.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115076.
    HOVERGENiHBG106004.
    InParanoidiQ6GU14.
    KOiK08530.
    OMAiSTPHYED.
    OrthoDBiEOG7X9G7F.
    TreeFamiTF316304.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003077. 1Cnucl_rcpt_G.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR022590. PPARgamma_N.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF12577. PPARgamma_N. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01291. PROXISOMPAGR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GU14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL    50
    SVMEDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ 100
    EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH 150
    YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA 200
    VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY 250
    IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 300
    QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV 350
    HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV 400
    KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK 450
    LNHPESSQLF AKVLQKMTDL RQIVTEHVQL LHVIKKTETD MSLHPLLQEI 500
    YKDLY 505
    Length:505
    Mass (Da):57,571
    Last modified:May 10, 2005 - v1
    Checksum:iBA7F33909BE2A10A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC153828 Genomic DNA. No translation available.
    AC171970 Genomic DNA. No translation available.
    BC021798 mRNA. Translation: AAH21798.1.
    AY208183 mRNA. Translation: AAO45097.1.
    AY208184 mRNA. Translation: AAO45098.1.
    AY243585 mRNA. Translation: AAP42200.1.
    AB256529 Genomic DNA. Translation: BAF80899.1.
    AB256530 Genomic DNA. Translation: BAF80900.1.
    RefSeqiNP_035276.2. NM_011146.3.
    UniGeneiMm.3020.

    Genome annotation databases

    EnsembliENSMUST00000000450; ENSMUSP00000000450; ENSMUSG00000000440.
    GeneIDi19016.
    KEGGimmu:19016.
    UCSCiuc009dis.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC153828 Genomic DNA. No translation available.
    AC171970 Genomic DNA. No translation available.
    BC021798 mRNA. Translation: AAH21798.1 .
    AY208183 mRNA. Translation: AAO45097.1 .
    AY208184 mRNA. Translation: AAO45098.1 .
    AY243585 mRNA. Translation: AAP42200.1 .
    AB256529 Genomic DNA. Translation: BAF80899.1 .
    AB256530 Genomic DNA. Translation: BAF80900.1 .
    RefSeqi NP_035276.2. NM_011146.3.
    UniGenei Mm.3020.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000450 ; ENSMUSP00000000450 ; ENSMUSG00000000440 .
    GeneIDi 19016.
    KEGGi mmu:19016.
    UCSCi uc009dis.2. mouse.

    Organism-specific databases

    CTDi 5468.
    MGIi MGI:97747. Pparg.

    Phylogenomic databases

    GeneTreei ENSGT00740000115076.
    HOVERGENi HBG106004.
    InParanoidi Q6GU14.
    KOi K08530.
    OMAi STPHYED.
    OrthoDBi EOG7X9G7F.
    TreeFami TF316304.

    Miscellaneous databases

    NextBioi 295444.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6GU14.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003077. 1Cnucl_rcpt_G.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR022590. PPARgamma_N.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF12577. PPARgamma_N. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01291. PROXISOMPAGR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice."
      Lyons M.A., Wittenburg H., Li R., Walsh K.A., Churchill G.A., Carey M.C., Paigen B.
      J. Lipid Res. 44:953-967(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CAST/EiImported and DBA/2JImported.
      Tissue: LiverImported.
    2. "New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice."
      Lyons M.A., Wittenburg H., Li R., Walsh K.A., Leonard M.R., Churchill G.A., Carey M.C., Paigen B.
      Physiol. Genomics 14:225-239(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129S1/SvImJImported.
      Tissue: LiverImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Salivary glandImported.
    4. "Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes."
      Babaya M., Ikegami H., Fujisawa T.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/HeImported and NSYImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    6. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6GU14_MOUSE
    AccessioniPrimary (citable) accession number: Q6GU14
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3