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Q6GU14 (Q6GU14_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Peroxisome proliferator-activated receptor gamma Ensembl ENSMUSP00000000450 EMBL BAF80899.1

Peroxisome proliferator-activated receptor gamma isoform 2 EMBL AAO45097.1

Peroxisome proliferator-activated receptor gamma transcript 2 EMBL AAP42200.1
Gene names
Name:Pparg EMBL AAH21798.1 Ensembl ENSMUSP00000000450 MGI 97747
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAH21798.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS008946 RuleBase RU004334
   Cellular componentNucleus SAAS SAAS008946 RuleBase RU004334
   DomainZinc-finger SAAS SAAS008946 RuleBase RU004334
   LigandDNA-binding SAAS SAAS008946 RuleBase RU004334
Metal-binding
Zinc
   Molecular functionReceptor RuleBase RU004334 EMBL AAH21798.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

brown fat cell differentiation

Inferred from direct assay PubMed 18492766. Source: MGI

cell fate commitment

Inferred from genetic interaction PubMed 15687259. Source: MGI

cell maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to insulin stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to lithium ion

Inferred from direct assay PubMed 15673614. Source: MGI

cellular response to organic cyclic compound

Inferred from direct assay PubMed 12055200. Source: MGI

epithelial cell differentiation

Inferred from genetic interaction PubMed 15687259. Source: MGI

fat cell differentiation

Inferred from direct assay PubMed 12037571PubMed 12502791. Source: MGI

fatty acid oxidation

Inferred from electronic annotation. Source: Ensembl

glucose homeostasis

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Traceable author statement PubMed 12163159. Source: MGI

lipoprotein transport

Inferred from electronic annotation. Source: Ensembl

long-chain fatty acid transport

Inferred from mutant phenotype PubMed 17463056. Source: MGI

low-density lipoprotein particle receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

monocyte differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of acute inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 12370429. Source: MGI

negative regulation of cholesterol storage

Inferred from electronic annotation. Source: Ensembl

negative regulation of interferon-gamma-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of sequestering of triglyceride

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of telomerase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8041794. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 15681609. Source: MGI

organ regeneration

Inferred from electronic annotation. Source: Ensembl

peroxisome proliferator activated receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

placenta development

Inferred from mutant phenotype PubMed 17463056. Source: MGI

positive regulation of fat cell differentiation

Inferred from direct assay PubMed 10937998PubMed 15175325PubMed 15728361. Source: MGI

positive regulation of fatty acid oxidation

Inferred from electronic annotation. Source: Ensembl

positive regulation of oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12037571PubMed 16099986PubMed 22226965. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 14744933PubMed 15684432. Source: MGI

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

regulation of fat cell differentiation

Inferred from direct assay PubMed 12097321. Source: MGI

response to caffeine

Inferred from electronic annotation. Source: Ensembl

response to cold

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to low-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

response to vitamin A

Inferred from electronic annotation. Source: Ensembl

white fat cell differentiation

Inferred from direct assay PubMed 18492766. Source: MGI

   Cellular_componentcytosol

Inferred from direct assay PubMed 12163159PubMed 15164767. Source: MGI

nucleus

Inferred from direct assay PubMed 12163159PubMed 15164767PubMed 21669876. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12037571PubMed 15232616PubMed 15681609PubMed 8041794. Source: MGI

RNA polymerase II regulatory region DNA binding

Inferred from direct assay PubMed 15175325. Source: MGI

RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from direct assay PubMed 23275342. Source: MGI

chromatin binding

Inferred from direct assay PubMed 19066220PubMed 23275342. Source: MGI

drug binding

Inferred from electronic annotation. Source: Ensembl

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Traceable author statement PubMed 12163159. Source: MGI

ligand-dependent nuclear receptor transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 12037571. Source: MGI

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6GU14 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: BA7F33909BE2A10A

FASTA50557,571
        10         20         30         40         50         60 
MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 

        70         80         90        100        110        120 
DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 

       130        140        150        160        170        180 
QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC 

       190        200        210        220        230        240 
RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR 

       250        260        270        280        290        300 
ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 

       310        320        330        340        350        360 
QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS 

       370        380        390        400        410        420 
LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII 

       430        440        450        460        470        480 
LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL 

       490        500 
LHVIKKTETD MSLHPLLQEI YKDLY 

« Hide

References

« Hide 'large scale' references
[1]"Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice."
Lyons M.A., Wittenburg H., Li R., Walsh K.A., Churchill G.A., Carey M.C., Paigen B.
J. Lipid Res. 44:953-967(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CAST/Ei EMBL AAO45097.1 and DBA/2J EMBL AAO45098.1.
Tissue: Liver EMBL AAO45097.1.
[2]"New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice."
Lyons M.A., Wittenburg H., Li R., Walsh K.A., Leonard M.R., Churchill G.A., Carey M.C., Paigen B.
Physiol. Genomics 14:225-239(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129S1/SvImJ EMBL AAP42200.1.
Tissue: Liver EMBL AAP42200.1.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH21798.1.
Tissue: Salivary gland EMBL AAH21798.1.
[4]"Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes."
Babaya M., Ikegami H., Fujisawa T.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C3H/He EMBL BAF80900.1 and NSY EMBL BAF80899.1.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000000450.
[6]Ensembl
Submitted (JUN-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000000450.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC153828 Genomic DNA. No translation available.
AC171970 Genomic DNA. No translation available.
BC021798 mRNA. Translation: AAH21798.1.
AY208183 mRNA. Translation: AAO45097.1.
AY208184 mRNA. Translation: AAO45098.1.
AY243585 mRNA. Translation: AAP42200.1.
AB256529 Genomic DNA. Translation: BAF80899.1.
AB256530 Genomic DNA. Translation: BAF80900.1.
RefSeqNP_035276.2. NM_011146.3.
UniGeneMm.3020.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000450; ENSMUSP00000000450; ENSMUSG00000000440.
GeneID19016.
KEGGmmu:19016.
UCSCuc009dis.2. mouse.

Organism-specific databases

CTD5468.
MGIMGI:97747. Pparg.

Phylogenomic databases

GeneTreeENSGT00740000115076.
HOVERGENHBG106004.
InParanoidQ6GU14.
KOK08530.
OMASTPHYED.
OrthoDBEOG7X9G7F.
TreeFamTF316304.

Gene expression databases

GenevestigatorQ6GU14.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR022590. PPARgamma_N.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295444.
SOURCESearch...

Entry information

Entry nameQ6GU14_MOUSE
AccessionPrimary (citable) accession number: Q6GU14
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)