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Protein
Submitted name:

Peroxisome proliferator activated receptor gamma

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. activating transcription factor binding Source: MGI
  2. chromatin binding Source: MGI
  3. DNA binding Source: MGI
  4. drug binding Source: MGI
  5. enzyme binding Source: MGI
  6. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
  8. retinoid X receptor binding Source: MGI
  9. RNA polymerase II regulatory region DNA binding Source: MGI
  10. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  11. sequence-specific DNA binding Source: InterPro
  12. sequence-specific DNA binding transcription factor activity Source: MGI
  13. steroid hormone receptor activity Source: InterPro
  14. transcription regulatory region DNA binding Source: MGI
  15. WW domain binding Source: MGI
  16. zinc ion binding Source: InterPro

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. brown fat cell differentiation Source: MGI
  3. cell fate commitment Source: MGI
  4. cell maturation Source: MGI
  5. cellular response to hyperoxia Source: Ensembl
  6. cellular response to insulin stimulus Source: MGI
  7. cellular response to lithium ion Source: MGI
  8. cellular response to organic cyclic compound Source: MGI
  9. cellular response to prostaglandin E stimulus Source: Ensembl
  10. cellular response to retinoic acid Source: Ensembl
  11. cellular response to vitamin E Source: Ensembl
  12. epithelial cell differentiation Source: MGI
  13. fat cell differentiation Source: MGI
  14. fatty acid oxidation Source: Ensembl
  15. glucose homeostasis Source: MGI
  16. heart development Source: Ensembl
  17. inflammatory response Source: MGI
  18. lipoprotein transport Source: MGI
  19. long-chain fatty acid transport Source: MGI
  20. low-density lipoprotein particle receptor biosynthetic process Source: MGI
  21. monocyte differentiation Source: MGI
  22. negative regulation of acute inflammatory response Source: Ensembl
  23. negative regulation of cell growth Source: Ensembl
  24. negative regulation of cell proliferation Source: MGI
  25. negative regulation of cholesterol storage Source: MGI
  26. negative regulation of collagen biosynthetic process Source: Ensembl
  27. negative regulation of interferon-gamma-mediated signaling pathway Source: MGI
  28. negative regulation of macrophage derived foam cell differentiation Source: MGI
  29. negative regulation of pancreatic stellate cell proliferation Source: Ensembl
  30. negative regulation of receptor biosynthetic process Source: MGI
  31. negative regulation of sequestering of triglyceride Source: MGI
  32. negative regulation of smooth muscle cell proliferation Source: MGI
  33. negative regulation of telomerase activity Source: Ensembl
  34. negative regulation of transcription, DNA-templated Source: MGI
  35. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  36. organ regeneration Source: Ensembl
  37. peroxisome proliferator activated receptor signaling pathway Source: MGI
  38. placenta development Source: MGI
  39. positive regulation of fat cell differentiation Source: MGI
  40. positive regulation of fatty acid oxidation Source: Ensembl
  41. positive regulation of oligodendrocyte differentiation Source: Ensembl
  42. positive regulation of phagocytosis, engulfment Source: Ensembl
  43. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  44. positive regulation of transcription, DNA-templated Source: MGI
  45. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  46. regulation of blood pressure Source: MGI
  47. regulation of fat cell differentiation Source: MGI
  48. response to caffeine Source: Ensembl
  49. response to cold Source: Ensembl
  50. response to diuretic Source: Ensembl
  51. response to estrogen Source: Ensembl
  52. response to immobilization stress Source: Ensembl
  53. response to low-density lipoprotein particle Source: MGI
  54. response to mechanical stimulus Source: Ensembl
  55. response to metformin Source: Ensembl
  56. response to retinoic acid Source: MGI
  57. response to starvation Source: Ensembl
  58. response to vitamin A Source: Ensembl
  59. signal transduction Source: MGI
  60. white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_234105. Nuclear Receptor transcription pathway.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activated receptor gammaImported
Submitted name:
Peroxisome proliferator-activated receptor gammaImported
Submitted name:
Peroxisome proliferator-activated receptor gamma isoform 2Imported
Submitted name:
Peroxisome proliferator-activated receptor gamma transcript 2Imported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:97747. Pparg.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. nucleus Source: MGI
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ6GU14.

Structurei

3D structure databases

ProteinModelPortaliQ6GU14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOVERGENiHBG106004.
KOiK08530.
OMAiHEEPSNS.
OrthoDBiEOG7X9G7F.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR022590. PPARgamma_N.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GU14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL
60 70 80 90 100
SVMEDHSHSF DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ
110 120 130 140 150
EYQSAIKVEP ASPPYYSEKT QLYNRPHEEP SNSLMAIECR VCGDKASGFH
160 170 180 190 200
YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA
210 220 230 240 250
VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY
260 270 280 290 300
IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE
310 320 330 340 350
QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV
360 370 380 390 400
HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV
410 420 430 440 450
KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK
460 470 480 490 500
LNHPESSQLF AKVLQKMTDL RQIVTEHVQL LHVIKKTETD MSLHPLLQEI

YKDLY
Length:505
Mass (Da):57,571
Last modified:May 10, 2005 - v1
Checksum:iBA7F33909BE2A10A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153828 Genomic DNA. No translation available.
AC171970 Genomic DNA. No translation available.
BC021798 mRNA. Translation: AAH21798.1.
AY208183 mRNA. Translation: AAO45097.1.
AY208184 mRNA. Translation: AAO45098.1.
AY243585 mRNA. Translation: AAP42200.1.
AB256529 Genomic DNA. Translation: BAF80899.1.
AB256530 Genomic DNA. Translation: BAF80900.1.
RefSeqiNP_035276.2. NM_011146.3.
UniGeneiMm.3020.

Genome annotation databases

EnsembliENSMUST00000000450; ENSMUSP00000000450; ENSMUSG00000000440.
GeneIDi19016.
KEGGimmu:19016.
UCSCiuc009dis.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153828 Genomic DNA. No translation available.
AC171970 Genomic DNA. No translation available.
BC021798 mRNA. Translation: AAH21798.1.
AY208183 mRNA. Translation: AAO45097.1.
AY208184 mRNA. Translation: AAO45098.1.
AY243585 mRNA. Translation: AAP42200.1.
AB256529 Genomic DNA. Translation: BAF80899.1.
AB256530 Genomic DNA. Translation: BAF80900.1.
RefSeqiNP_035276.2. NM_011146.3.
UniGeneiMm.3020.

3D structure databases

ProteinModelPortaliQ6GU14.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000450; ENSMUSP00000000450; ENSMUSG00000000440.
GeneIDi19016.
KEGGimmu:19016.
UCSCiuc009dis.2. mouse.

Organism-specific databases

CTDi5468.
MGIiMGI:97747. Pparg.

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOVERGENiHBG106004.
KOiK08530.
OMAiHEEPSNS.
OrthoDBiEOG7X9G7F.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_234105. Nuclear Receptor transcription pathway.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

NextBioi295444.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ6GU14.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR022590. PPARgamma_N.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice."
    Lyons M.A., Wittenburg H., Li R., Walsh K.A., Churchill G.A., Carey M.C., Paigen B.
    J. Lipid Res. 44:953-967(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CAST/EiImported and DBA/2JImported.
    Tissue: LiverImported.
  2. "New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice."
    Lyons M.A., Wittenburg H., Li R., Walsh K.A., Leonard M.R., Churchill G.A., Carey M.C., Paigen B.
    Physiol. Genomics 14:225-239(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129S1/SvImJImported.
    Tissue: LiverImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Salivary glandImported.
  4. "Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes."
    Babaya M., Ikegami H., Fujisawa T.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/HeImported and NSYImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6GU14_MOUSE
AccessioniPrimary (citable) accession number: Q6GU14
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.