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Protein

Probable carboxypeptidase PM20D1

Gene

PM20D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi125 – 1251Zinc 2By similarity
Active sitei127 – 1271By similarity
Metal bindingi157 – 1571Zinc 1By similarity
Metal bindingi157 – 1571Zinc 2By similarity
Active sitei191 – 1911Proton acceptorBy similarity
Metal bindingi192 – 1921Zinc 1By similarity
Metal bindingi217 – 2171Zinc 2By similarity
Metal bindingi464 – 4641Zinc 1By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of neuron death Source: UniProtKB
  • regulation of defense response to virus by host Source: UniProtKB
  • regulation of viral process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM20.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxypeptidase PM20D1 (EC:3.4.17.-)
Alternative name(s):
Peptidase M20 domain-containing protein 1
Gene namesi
Name:PM20D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26518. PM20D1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399772.

Polymorphism and mutation databases

BioMutaiPM20D1.
DMDMi317373406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 502477Probable carboxypeptidase PM20D1PRO_0000321928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6GTS8.
PeptideAtlasiQ6GTS8.
PRIDEiQ6GTS8.

PTM databases

iPTMnetiQ6GTS8.
PhosphoSiteiQ6GTS8.

Expressioni

Gene expression databases

BgeeiQ6GTS8.
CleanExiHS_PM20D1.
GenevisibleiQ6GTS8. HS.

Organism-specific databases

HPAiHPA017571.

Interactioni

Protein-protein interaction databases

BioGridi127171. 2 interactions.
STRINGi9606.ENSP00000356104.

Structurei

3D structure databases

ProteinModelPortaliQ6GTS8.
SMRiQ6GTS8. Positions 65-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2275. Eukaryota.
COG0624. LUCA.
GeneTreeiENSGT00840000129850.
HOGENOMiHOG000245216.
HOVERGENiHBG059923.
InParanoidiQ6GTS8.
KOiK13049.
OMAiCKNQLIA.
OrthoDBiEOG7N8ZVZ.
PhylomeDBiQ6GTS8.
TreeFamiTF328688.

Family and domain databases

Gene3Di3.30.70.360. 2 hits.
InterProiIPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6GTS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRCVCVLA LVAMLLLVFP TVSRSMGPRS GEHQRASRIP SQFSKEERVA
60 70 80 90 100
MKEALKGAIQ IPTVTFSSEK SNTTALAEFG KYIHKVFPTV VSTSFIQHEV
110 120 130 140 150
VEEYSHLFTI QGSDPSLQPY LLMAHFDVVP APEEGWEVPP FSGLERDGII
160 170 180 190 200
YGRGTLDDKN SVMALLQALE LLLIRKYIPR RSFFISLGHD EESSGTGAQR
210 220 230 240 250
ISALLQSRGV QLAFIVDEGG FILDDFIPNF KKPIALIAVS EKGSMNLMLQ
260 270 280 290 300
VNMTSGHSSA PPKETSIGIL AAAVSRLEQT PMPIIFGSGT VVTVLQQLAN
310 320 330 340 350
EFPFPVNIIL SNPWLFEPLI SRFMERNPLT NAIIRTTTAL TIFKAGVKFN
360 370 380 390 400
VIPPVAQATV NFRIHPGQTV QEVLELTKNI VADNRVQFHV LSAFDPLPVS
410 420 430 440 450
PSDDKALGYQ LLRQTVQSVF PEVNITAPVT SIGNTDSRFF TNLTTGIYRF
460 470 480 490 500
YPIYIQPEDF KRIHGVNEKI SVQAYETQVK FIFELIQNAD TDQEPVSHLH

KL
Length:502
Mass (Da):55,741
Last modified:January 11, 2011 - v3
Checksum:i0CC2C45E1A7ADEA8
GO
Isoform 2 (identifier: Q6GTS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-361: FPFPVNIILS...IPPVAQATVN → VYGEKSLNQC...GPRTHEEHCG
     362-502: Missing.

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):39,544
Checksum:i74340982D6CE39A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841H → R in AAH39170 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331H → Y.1 Publication
Corresponds to variant rs11540014 [ dbSNP | Ensembl ].
VAR_039380
Natural varianti149 – 1491I → V.2 Publications
Corresponds to variant rs1891460 [ dbSNP | Ensembl ].
VAR_039381
Natural varianti153 – 1531R → W.2 Publications
Corresponds to variant rs1104899 [ dbSNP | Ensembl ].
VAR_039382
Natural varianti237 – 2371I → T.1 Publication
Corresponds to variant rs7518979 [ dbSNP | Ensembl ].
VAR_039383
Natural varianti258 – 2581S → C.
Corresponds to variant rs11581214 [ dbSNP | Ensembl ].
VAR_039384
Natural varianti346 – 3461G → R.1 Publication
Corresponds to variant rs11240573 [ dbSNP | Ensembl ].
VAR_039385
Natural varianti380 – 3801I → T.1 Publication
Corresponds to variant rs1361754 [ dbSNP | Ensembl ].
VAR_039386

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei302 – 36160FPFPV…QATVN → VYGEKSLNQCNNQDHHGTHH IQSRGQVQCHPPSGPGHSQL PDSPWTDSPRGPRTHEEHCG in isoform 2. 1 PublicationVSP_031826Add
BLAST
Alternative sequencei362 – 502141Missing in isoform 2. 1 PublicationVSP_031827Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057131 mRNA. Translation: BAB71368.1.
AK290786 mRNA. Translation: BAF83475.1.
AC119673 Genomic DNA. No translation available.
BC039170 mRNA. Translation: AAH39170.1.
BC063477 mRNA. Translation: AAH63477.1.
CCDSiCCDS1460.1. [Q6GTS8-1]
RefSeqiNP_689704.4. NM_152491.4. [Q6GTS8-1]
UniGeneiHs.177744.

Genome annotation databases

EnsembliENST00000367136; ENSP00000356104; ENSG00000162877. [Q6GTS8-1]
GeneIDi148811.
KEGGihsa:148811.
UCSCiuc001hdj.4. human. [Q6GTS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057131 mRNA. Translation: BAB71368.1.
AK290786 mRNA. Translation: BAF83475.1.
AC119673 Genomic DNA. No translation available.
BC039170 mRNA. Translation: AAH39170.1.
BC063477 mRNA. Translation: AAH63477.1.
CCDSiCCDS1460.1. [Q6GTS8-1]
RefSeqiNP_689704.4. NM_152491.4. [Q6GTS8-1]
UniGeneiHs.177744.

3D structure databases

ProteinModelPortaliQ6GTS8.
SMRiQ6GTS8. Positions 65-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127171. 2 interactions.
STRINGi9606.ENSP00000356104.

Protein family/group databases

MEROPSiM20.011.

PTM databases

iPTMnetiQ6GTS8.
PhosphoSiteiQ6GTS8.

Polymorphism and mutation databases

BioMutaiPM20D1.
DMDMi317373406.

Proteomic databases

PaxDbiQ6GTS8.
PeptideAtlasiQ6GTS8.
PRIDEiQ6GTS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367136; ENSP00000356104; ENSG00000162877. [Q6GTS8-1]
GeneIDi148811.
KEGGihsa:148811.
UCSCiuc001hdj.4. human. [Q6GTS8-1]

Organism-specific databases

CTDi148811.
GeneCardsiPM20D1.
HGNCiHGNC:26518. PM20D1.
HPAiHPA017571.
neXtProtiNX_Q6GTS8.
PharmGKBiPA162399772.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2275. Eukaryota.
COG0624. LUCA.
GeneTreeiENSGT00840000129850.
HOGENOMiHOG000245216.
HOVERGENiHBG059923.
InParanoidiQ6GTS8.
KOiK13049.
OMAiCKNQLIA.
OrthoDBiEOG7N8ZVZ.
PhylomeDBiQ6GTS8.
TreeFamiTF328688.

Miscellaneous databases

GenomeRNAii148811.
PROiQ6GTS8.

Gene expression databases

BgeeiQ6GTS8.
CleanExiHS_PM20D1.
GenevisibleiQ6GTS8. HS.

Family and domain databases

Gene3Di3.30.70.360. 2 hits.
InterProiIPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-149 AND TRP-153.
    Tissue: Kidney and Spleen.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS TYR-33; VAL-149; TRP-153; THR-237; ARG-346 AND THR-380.
    Tissue: Pancreas and Skin.

Entry informationi

Entry nameiP20D1_HUMAN
AccessioniPrimary (citable) accession number: Q6GTS8
Secondary accession number(s): Q6P4E3, Q96DM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.