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Protein
Submitted name:

Cytotoxic T-lymphocyte protein 4

Gene

Ctla4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-389513 CTLA4 inhibitory signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Cytotoxic T-lymphocyte protein 4Imported
Submitted name:
Cytotoxic T-lymphocyte-associated protein 4Imported
Gene namesi
Name:Ctla4Imported
ORF Names:CH29-120A16.2-001Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:88556 Ctla4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei162 – 186HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_501458730438 – 223Sequence analysisAdd BLAST186

Expressioni

Gene expression databases

BgeeiENSMUSG00000026011

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 132Ig-likeInterPro annotationAdd BLAST101

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ05 Eukaryota
ENOG410YUQR LUCA
GeneTreeiENSGT00530000063873
HOVERGENiHBG057978
KOiK06538
OMAiFSKGMHV
OrthoDBiEOG091G0IGY
TreeFamiTF335679

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008096 CTLA4
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PANTHERiPTHR11494:SF8 PTHR11494:SF8, 1 hit
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PRINTSiPR01720 CTLANTIGEN4
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GTR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLGLRRYK AQLQLPSRTW PFVALLTLLF IPVFSEAIQV TQPSVVLASS
60 70 80 90 100
HGVASFPCEY SPSHNTDEVR VTVLRQTNDQ MTEVCATTFT EKNTVGFLDY
110 120 130 140 150
PFCSGTFNES RVNLTIQGLR AVDTGLYLCK VELMYPPPYF VGMGNGTQIY
160 170 180 190 200
VIDPEPCPDS DFLLWILVAV SLGLFFYSFL VTAVSLSKML KKRSPLTTGV
210 220
YVKMPPTEPE CEKQFQPYFI PIN
Length:223
Mass (Da):25,007
Last modified:May 10, 2005 - v1
Checksum:i531E4C742A6F4685
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646054 Genomic DNA No translation available.
AL663047 Genomic DNA No translation available.
BC042741 mRNA Translation: AAH42741.1
GQ420692 Genomic DNA Translation: ACX50465.1
GQ420693 Genomic DNA Translation: ACX50466.1
CR936839 Genomic DNA Translation: CAM13245.1
RefSeqiNP_033973.2, NM_009843.4
UniGeneiMm.390

Genome annotation databases

EnsembliENSMUST00000027164; ENSMUSP00000027164; ENSMUSG00000026011
GeneIDi12477
KEGGimmu:12477
UCSCiuc007bez.2 mouse

Entry informationi

Entry nameiQ6GTR6_MOUSE
AccessioniPrimary (citable) accession number: Q6GTR6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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