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Protein
Submitted name:

Cytochrome P450 family 3 subfamily A polypeptide 4

Gene

CYP3A4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 family 3 subfamily A polypeptide 4Imported
Submitted name:
Cytochrome P450, family 3, subfamily A, polypeptide 4Imported
Submitted name:
Cytochrome P450, family 3, subfamily A, polypeptide 4, isoform CRA_aImported
Submitted name:
Cytochrome P450, subfamily IIIA, polypeptide 4Imported
Submitted name:
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNAImported
Gene namesi
Name:CYP3A4Imported
ORF Names:hCG_17094Imported, tcag7.603Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA130.

PTM / Processingi

Proteomic databases

MaxQBiQ6GRK0.

Expressioni

Gene expression databases

BgeeiENSG00000160868.
ExpressionAtlasiQ6GRK0. baseline and differential.

Structurei

3D structure databases

SMRiQ6GRK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG108567.
KOiK17689.
OMAiTYSMGNV.
OrthoDBiEOG091G0JNC.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GRK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI
60 70 80 90 100
LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR
260 270 280 290 300
KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV
360 370 380 390 400
LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA
410 420 430 440 450
LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM
460 470 480 490 500
NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV

SGA
Length:503
Mass (Da):57,343
Last modified:May 10, 2005 - v1
Checksum:i38ED122BF89F74F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC069418 mRNA. Translation: AAH69418.1.
BC101631 mRNA. Translation: AAI01632.1.
DQ005611 Genomic DNA. Translation: AAY16980.1.
DQ924960 mRNA. Translation: ABI96208.1.
AK312967 mRNA. Translation: BAG35806.1.
CH236956 Genomic DNA. Translation: EAL23866.1.
CH471091 Genomic DNA. Translation: EAW76635.1.
RefSeqiNP_001189784.1. NM_001202855.2.
NP_059488.2. NM_017460.5.
UniGeneiHs.728751.

Genome annotation databases

GeneIDi1576.
KEGGihsa:1576.
UCSCiuc003urv.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6GRK0_HUMAN
AccessioniPrimary (citable) accession number: Q6GRK0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 5, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.