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Protein
Submitted name:

Cytochrome P450 family 3 subfamily A polypeptide 4

Gene

CYP3A4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

hemeSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenaseUniRule annotationSAAS annotation, Oxidoreductase
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 family 3 subfamily A polypeptide 4Imported
Submitted name:
Cytochrome P450, family 3, subfamily A, polypeptide 4Imported
Submitted name:
Cytochrome P450, family 3, subfamily A, polypeptide 4, isoform CRA_aImported
Submitted name:
Cytochrome P450, subfamily IIIA, polypeptide 4Imported
Submitted name:
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNAImported
Gene namesi
Name:CYP3A4Imported
ORF Names:hCG_17094Imported, tcag7.603Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000160868.14

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA130

PTM / Processingi

Proteomic databases

MaxQBiQ6GRK0
PRIDEiQ6GRK0

Expressioni

Gene expression databases

BgeeiENSG00000160868
ExpressionAtlasiQ6GRK0 baseline and differential

Structurei

3D structure databases

SMRiQ6GRK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
HOVERGENiHBG108567
KOiK17689
OMAiMAFEDIQ
OrthoDBiEOG091G0JNC

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GRK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI
60 70 80 90 100
LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR
260 270 280 290 300
KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV
360 370 380 390 400
LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA
410 420 430 440 450
LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM
460 470 480 490 500
NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV

SGA
Length:503
Mass (Da):57,343
Last modified:May 10, 2005 - v1
Checksum:i38ED122BF89F74F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC069418 mRNA Translation: AAH69418.1
BC101631 mRNA Translation: AAI01632.1
DQ005611 Genomic DNA Translation: AAY16980.1
DQ924960 mRNA Translation: ABI96208.1
AK312967 mRNA Translation: BAG35806.1
CH236956 Genomic DNA Translation: EAL23866.1
CH471091 Genomic DNA Translation: EAW76635.1
RefSeqiNP_001189784.1, NM_001202855.2
NP_059488.2, NM_017460.5
UniGeneiHs.728751

Genome annotation databases

GeneIDi1576
KEGGihsa:1576
UCSCiuc003urv.3 human

Similar proteinsi

Entry informationi

Entry nameiQ6GRK0_HUMAN
AccessioniPrimary (citable) accession number: Q6GRK0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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