Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6GR78

- Q6GR78_MOUSE

UniProt

Q6GR78 - Q6GR78_MOUSE

Protein
Submitted name:

Amyloid beta (A4) protein

Gene

App

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. heparin binding Source: InterPro
    3. peptidase activator activity Source: Ensembl
    4. protein binding Source: MGI
    5. serine-type endopeptidase inhibitor activity Source: Ensembl
    6. transition metal ion binding Source: InterPro

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. axon cargo transport Source: MGI
    3. axon midline choice point recognition Source: MGI
    4. axonogenesis Source: MGI
    5. cellular copper ion homeostasis Source: MGI
    6. cholesterol metabolic process Source: MGI
    7. collateral sprouting in absence of injury Source: MGI
    8. dendrite development Source: MGI
    9. endocytosis Source: MGI
    10. extracellular matrix organization Source: MGI
    11. forebrain development Source: MGI
    12. ionotropic glutamate receptor signaling pathway Source: MGI
    13. locomotory behavior Source: MGI
    14. mating behavior Source: MGI
    15. mRNA polyadenylation Source: MGI
    16. negative regulation of neuron differentiation Source: MGI
    17. neuromuscular process controlling balance Source: MGI
    18. neuron apoptotic process Source: MGI
    19. neuron projection development Source: MGI
    20. neuron remodeling Source: MGI
    21. positive regulation of G2/M transition of mitotic cell cycle Source: MGI
    22. positive regulation of mitotic cell cycle Source: MGI
    23. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    24. protein homooligomerization Source: MGI
    25. protein phosphorylation Source: MGI
    26. regulation of epidermal growth factor-activated receptor activity Source: MGI
    27. regulation of gene expression Source: MGI
    28. regulation of multicellular organism growth Source: MGI
    29. regulation of protein binding Source: MGI
    30. regulation of synapse structure and activity Source: MGI
    31. regulation of translation Source: MGI
    32. response to oxidative stress Source: MGI
    33. smooth endoplasmic reticulum calcium ion homeostasis Source: MGI
    34. suckling behavior Source: MGI
    35. synaptic growth at neuromuscular junction Source: MGI
    36. visual learning Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Amyloid beta (A4) proteinImported
    Submitted name:
    Amyloid beta (A4) protein, isoform CRA_bImported
    Gene namesi
    Name:AppImported
    ORF Names:mCG_129417Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88059. App.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: MGI
    2. axon Source: MGI
    3. cell-cell junction Source: MGI
    4. cell surface Source: Ensembl
    5. ciliary rootlet Source: MGI
    6. cytoplasm Source: MGI
    7. cytoplasmic vesicle Source: MGI
    8. dendritic shaft Source: Ensembl
    9. dendritic spine Source: Ensembl
    10. ER to Golgi transport vesicle Source: MGI
    11. Golgi apparatus Source: MGI
    12. integral component of membrane Source: MGI
    13. membrane Source: MGI
    14. neuromuscular junction Source: MGI
    15. neuron projection Source: MGI
    16. perinuclear region of cytoplasm Source: MGI
    17. plasma membrane Source: MGI
    18. receptor complex Source: MGI
    19. spindle midzone Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ6GR78.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000063252.
    HOVERGENiHBG000051.
    KOiK04520.
    OMAiTHAHIVI.

    Family and domain databases

    Gene3Di3.30.1490.140. 1 hit.
    3.90.570.10. 1 hit.
    4.10.230.10. 1 hit.
    InterProiIPR008155. Amyloid_glyco.
    IPR013803. Amyloid_glyco_Abeta.
    IPR011178. Amyloid_glyco_Cu-bd.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR008154. Amyloid_glyco_extra.
    IPR019744. Amyloid_glyco_extracell_CS.
    IPR015849. Amyloid_glyco_heparin-bd.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR028866. APP.
    IPR019543. APP_amyloid_C.
    [Graphical view]
    PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
    PfamiPF10515. APP_amyloid. 1 hit.
    PF12924. APP_Cu_bd. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF02177. APP_N. 1 hit.
    PF03494. Beta-APP. 1 hit.
    [Graphical view]
    PRINTSiPR00203. AMYLOIDA4.
    PR00204. BETAAMYLOID.
    SMARTiSM00006. A4_EXTRA. 1 hit.
    [Graphical view]
    SUPFAMiSSF109843. SSF109843. 1 hit.
    SSF56491. SSF56491. 1 hit.
    SSF89811. SSF89811. 1 hit.
    PROSITEiPS00319. A4_EXTRA. 1 hit.
    PS00320. A4_INTRA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GR78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG    50
    KWESDPSGTK TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR 100
    GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW 150
    HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD 200
    AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED 250
    GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV 300
    DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK 350
    ADKKAVIQHF QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN 400
    YITALQAVPP RPHHVFNMLK KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ 450
    IRSQVMTHLR VIYERMNQSL SLLYNVPAVA EEIQDEVDEL LQKEQNYSDD 500
    VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL DDLQPWHPFG 550
    VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF 600
    GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK 650
    KQYTSIHHGV VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN 695
    Length:695
    Mass (Da):78,443
    Last modified:May 10, 2005 - v1
    Checksum:i0DE93FA56FB20F3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070409 mRNA. Translation: AAH70409.1.
    AK147543 mRNA. Translation: BAE27986.1.
    CH466521 Genomic DNA. Translation: EDK98319.1.
    RefSeqiNP_001185752.1. NM_001198823.1.
    NP_001185753.1. NM_001198824.1.
    NP_001185754.1. NM_001198825.1.
    NP_001185755.1. NM_001198826.1.
    NP_031497.2. NM_007471.3.
    UniGeneiMm.277585.
    Mm.489029.
    Mm.490986.

    Genome annotation databases

    GeneIDi11820.
    KEGGimmu:11820.
    UCSCiuc007zto.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070409 mRNA. Translation: AAH70409.1 .
    AK147543 mRNA. Translation: BAE27986.1 .
    CH466521 Genomic DNA. Translation: EDK98319.1 .
    RefSeqi NP_001185752.1. NM_001198823.1.
    NP_001185753.1. NM_001198824.1.
    NP_001185754.1. NM_001198825.1.
    NP_001185755.1. NM_001198826.1.
    NP_031497.2. NM_007471.3.
    UniGenei Mm.277585.
    Mm.489029.
    Mm.490986.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11820.
    KEGGi mmu:11820.
    UCSCi uc007zto.2. mouse.

    Organism-specific databases

    CTDi 351.
    MGIi MGI:88059. App.

    Phylogenomic databases

    GeneTreei ENSGT00530000063252.
    HOVERGENi HBG000051.
    KOi K04520.
    OMAi THAHIVI.

    Miscellaneous databases

    ChiTaRSi app. mouse.
    NextBioi 279717.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6GR78.

    Family and domain databases

    Gene3Di 3.30.1490.140. 1 hit.
    3.90.570.10. 1 hit.
    4.10.230.10. 1 hit.
    InterProi IPR008155. Amyloid_glyco.
    IPR013803. Amyloid_glyco_Abeta.
    IPR011178. Amyloid_glyco_Cu-bd.
    IPR024329. Amyloid_glyco_E2_domain.
    IPR008154. Amyloid_glyco_extra.
    IPR019744. Amyloid_glyco_extracell_CS.
    IPR015849. Amyloid_glyco_heparin-bd.
    IPR019745. Amyloid_glyco_intracell_CS.
    IPR028866. APP.
    IPR019543. APP_amyloid_C.
    [Graphical view ]
    PANTHERi PTHR23103:SF7. PTHR23103:SF7. 1 hit.
    Pfami PF10515. APP_amyloid. 1 hit.
    PF12924. APP_Cu_bd. 1 hit.
    PF12925. APP_E2. 1 hit.
    PF02177. APP_N. 1 hit.
    PF03494. Beta-APP. 1 hit.
    [Graphical view ]
    PRINTSi PR00203. AMYLOIDA4.
    PR00204. BETAAMYLOID.
    SMARTi SM00006. A4_EXTRA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109843. SSF109843. 1 hit.
    SSF56491. SSF56491. 1 hit.
    SSF89811. SSF89811. 1 hit.
    PROSITEi PS00319. A4_EXTRA. 1 hit.
    PS00320. A4_INTRA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    9. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    10. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    11. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ6GR78_MOUSE
    AccessioniPrimary (citable) accession number: Q6GR78
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)