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Protein
Submitted name:

Amyloid beta (A4) protein

Gene

App

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid beta (A4) proteinImported
Submitted name:
Amyloid beta (A4) protein, isoform CRA_bImported
Gene namesi
Name:AppImported
ORF Names:mCG_129417Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88059. App.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei626 – 648HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501084512118 – 695Sequence analysisAdd BLAST678

Proteomic databases

MaxQBiQ6GR78.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022892.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6GR78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 188A4_EXTRAInterPro annotationAdd BLAST165

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili350 – 384Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
HOVERGENiHBG000051.
KOiK04520.
OMAiREVCSEQ.
OrthoDBiEOG091G0UW4.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
InterProiView protein in InterPro
IPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
PANTHERiPTHR23103:SF17. PTHR23103:SF17. 1 hit.
PfamiView protein in Pfam
PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PRINTSiPR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
SMARTiView protein in SMART
SM00006. A4_EXTRA. 1 hit.
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiView protein in PROSITE
PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GR78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG
60 70 80 90 100
KWESDPSGTK TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR
110 120 130 140 150
GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW
160 170 180 190 200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD
210 220 230 240 250
AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED
260 270 280 290 300
GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV
310 320 330 340 350
DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK
360 370 380 390 400
ADKKAVIQHF QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN
410 420 430 440 450
YITALQAVPP RPHHVFNMLK KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ
460 470 480 490 500
IRSQVMTHLR VIYERMNQSL SLLYNVPAVA EEIQDEVDEL LQKEQNYSDD
510 520 530 540 550
VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL DDLQPWHPFG
560 570 580 590 600
VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF
610 620 630 640 650
GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK
660 670 680 690
KQYTSIHHGV VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN
Length:695
Mass (Da):78,443
Last modified:May 10, 2005 - v1
Checksum:i0DE93FA56FB20F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070409 mRNA. Translation: AAH70409.1.
AK147543 mRNA. Translation: BAE27986.1.
CH466521 Genomic DNA. Translation: EDK98319.1.
RefSeqiNP_001185752.1. NM_001198823.1.
NP_001185753.1. NM_001198824.1.
NP_001185754.1. NM_001198825.1.
NP_001185755.1. NM_001198826.1.
NP_031497.2. NM_007471.3.
UniGeneiMm.277585.
Mm.489029.
Mm.490986.

Genome annotation databases

GeneIDi11820.
KEGGimmu:11820.
UCSCiuc007zto.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ6GR78_MOUSE
AccessioniPrimary (citable) accession number: Q6GR78
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)