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Protein
Submitted name:

Amyloid beta (A4) protein, isoform CRA_b

Gene

App

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid beta (A4) protein, isoform CRA_bImported
Gene namesi
Name:AppImported
ORF Names:mCG_129417Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88059 App

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei626 – 648HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501431046018 – 695Sequence analysisAdd BLAST678

Proteomic databases

MaxQBiQ6GR78
PRIDEiQ6GR78

Expressioni

Gene expression databases

BgeeiENSMUSG00000022892
ExpressionAtlasiQ6GR78 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6GR78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 188A4_EXTRAInterPro annotationAdd BLAST165

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili324 – 344Sequence analysisAdd BLAST21
Coiled coili350 – 384Sequence analysisAdd BLAST35
Coiled coili480 – 500Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3540 Eukaryota
ENOG410ZW2A LUCA
HOVERGENiHBG000051
KOiK04520
OMAiREVCSEQ
OrthoDBiEOG091G0UW4

Family and domain databases

Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.230.10, 1 hit
InterProiView protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR013803 Amyloid_glyco_Abeta
IPR037071 Amyloid_glyco_Abeta_sf
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR019744 Amyloid_glyco_extracell_CS
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR019745 Amyloid_glyco_intracell_CS
IPR028866 APP
IPR019543 APP_amyloid_C
IPR036176 E2_sf
IPR011993 PH-like_dom_sf
PANTHERiPTHR23103 PTHR23103, 2 hits
PTHR23103:SF7 PTHR23103:SF7, 2 hits
PfamiView protein in Pfam
PF10515 APP_amyloid, 1 hit
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PF03494 Beta-APP, 1 hit
PRINTSiPR00203 AMYLOIDA4
PR00204 BETAAMYLOID
SMARTiView protein in SMART
SM00006 A4_EXTRA, 1 hit
SUPFAMiSSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF89811 SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319 A4_EXTRA, 1 hit
PS00320 A4_INTRA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GR78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG
60 70 80 90 100
KWESDPSGTK TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR
110 120 130 140 150
GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW
160 170 180 190 200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD
210 220 230 240 250
AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED
260 270 280 290 300
GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV
310 320 330 340 350
DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK
360 370 380 390 400
ADKKAVIQHF QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN
410 420 430 440 450
YITALQAVPP RPHHVFNMLK KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ
460 470 480 490 500
IRSQVMTHLR VIYERMNQSL SLLYNVPAVA EEIQDEVDEL LQKEQNYSDD
510 520 530 540 550
VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL DDLQPWHPFG
560 570 580 590 600
VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF
610 620 630 640 650
GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK
660 670 680 690
KQYTSIHHGV VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN
Length:695
Mass (Da):78,443
Last modified:May 10, 2005 - v1
Checksum:i0DE93FA56FB20F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070409 mRNA Translation: AAH70409.1
AK147543 mRNA Translation: BAE27986.1
CH466521 Genomic DNA Translation: EDK98319.1
RefSeqiNP_001185752.1, NM_001198823.1
NP_001185753.1, NM_001198824.1
NP_001185754.1, NM_001198825.1
NP_001185755.1, NM_001198826.1
NP_031497.2, NM_007471.3
UniGeneiMm.277585
Mm.489029
Mm.490986

Genome annotation databases

GeneIDi11820
KEGGimmu:11820
UCSCiuc007zto.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6GR78_MOUSE
AccessioniPrimary (citable) accession number: Q6GR78
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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