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Q6GR78 (Q6GR78_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Amyloid beta (A4) protein, isoform CRA_b EMBL EDK98319.1
Gene names
Name:App MGI 88059 EMBL AAH70409.1
ORF Names:mCG_129417 EMBL EDK98319.1
OrganismMus musculus (Mouse) EMBL AAH70409.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processadult locomotory behavior

Inferred from mutant phenotype PubMed 10188929PubMed 7758106PubMed 8001115PubMed 9754878. Source: MGI

axon cargo transport

Inferred from mutant phenotype PubMed 11740561. Source: MGI

axon midline choice point recognition

Inferred from mutant phenotype PubMed 8001115. Source: MGI

axonogenesis

Inferred from mutant phenotype PubMed 9390996. Source: MGI

cellular copper ion homeostasis

Inferred from mutant phenotype PubMed 10526140. Source: MGI

cholesterol metabolic process

Inferred from mutant phenotype PubMed 17920016. Source: MGI

collateral sprouting in absence of injury

Inferred from genetic interaction PubMed 15689559. Source: MGI

dendrite development

Inferred from mutant phenotype PubMed 10188929PubMed 9390996. Source: MGI

endocytosis

Inferred from mutant phenotype PubMed 16025111. Source: MGI

extracellular matrix organization

Inferred from genetic interaction PubMed 15385965. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 10200318PubMed 8001115. Source: MGI

ionotropic glutamate receptor signaling pathway

Inferred from mutant phenotype PubMed 16025111. Source: MGI

locomotory behavior

Inferred from genetic interaction PubMed 9461064. Source: MGI

mRNA polyadenylation

Inferred from direct assay PubMed 16314516. Source: MGI

mating behavior

Inferred from genetic interaction PubMed 9461064. Source: MGI

negative regulation of neuron differentiation

Inferred from direct assay PubMed 18278038. Source: MGI

neuromuscular process controlling balance

Inferred from genetic interaction PubMed 9461064. Source: MGI

neuron apoptotic process

Inferred from genetic interaction PubMed 16478525. Source: MGI

neuron projection development

Inferred from direct assay PubMed 8083748. Source: MGI

neuron remodeling

Inferred from mutant phenotype PubMed 10219973. Source: MGI

positive regulation of G2/M transition of mitotic cell cycle

Inferred from mutant phenotype PubMed 15561424. Source: MGI

positive regulation of mitotic cell cycle

Inferred from mutant phenotype PubMed 15561424. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15944124. Source: MGI

protein phosphorylation

Inferred from mutant phenotype PubMed 16025111. Source: MGI

regulation of epidermal growth factor-activated receptor activity

Inferred from genetic interaction PubMed 17556541. Source: MGI

regulation of gene expression

Inferred from direct assay PubMed 12074840. Source: MGI

regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 9754878. Source: MGI

regulation of protein binding

Inferred from mutant phenotype PubMed 17920016. Source: MGI

regulation of synapse structure and activity

Inferred from mutant phenotype PubMed 10219973. Source: MGI

regulation of translation

Inferred from direct assay PubMed 16314516. Source: MGI

response to oxidative stress

Inferred from genetic interaction PubMed 16478525. Source: MGI

smooth endoplasmic reticulum calcium ion homeostasis

Inferred from genetic interaction PubMed 12431992. Source: MGI

suckling behavior

Inferred from genetic interaction PubMed 9461064. Source: MGI

synaptic growth at neuromuscular junction

Inferred from genetic interaction PubMed 15689559. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 10338291. Source: MGI

   Cellular_componentER to Golgi transport vesicle

Inferred from direct assay PubMed 19966784. Source: MGI

Golgi apparatus

Inferred from direct assay PubMed 16018997. Source: MGI

apical part of cell

Inferred from direct assay PubMed 15561424. Source: MGI

axon

Inferred from direct assay PubMed 11740561PubMed 15745965. Source: MGI

cell surface

Inferred from electronic annotation. Source: Ensembl

cell-cell junction

Inferred from direct assay PubMed 23793062. Source: MGI

ciliary rootlet

Inferred from direct assay PubMed 16018997. Source: MGI

cytoplasm

Inferred from direct assay PubMed 10845772. Source: MGI

cytoplasmic vesicle

Inferred from direct assay PubMed 11740561PubMed 15745965. Source: MGI

dendritic shaft

Inferred from electronic annotation. Source: Ensembl

dendritic spine

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from direct assay PubMed 12927782. Source: MGI

membrane

Inferred from direct assay PubMed 10845772PubMed 12927782PubMed 15886206PubMed 9535056. Source: MGI

neuromuscular junction

Inferred from direct assay PubMed 10845772. Source: MGI

neuron projection

Inferred from direct assay PubMed 16301330. Source: MGI

perinuclear region of cytoplasm

Inferred from direct assay PubMed 8207383. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15009636. Source: MGI

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

spindle midzone

Inferred from direct assay PubMed 15561424. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15944124. Source: MGI

heparin binding

Inferred from electronic annotation. Source: InterPro

peptidase activator activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 16314516PubMed 18278038PubMed 20497468PubMed 21795536. Source: MGI

serine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

transition metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6GR78 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 0DE93FA56FB20F3A

FASTA69578,443
        10         20         30         40         50         60 
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG KWESDPSGTK 

        70         80         90        100        110        120 
TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHTH IVIPYRCLVG 

       130        140        150        160        170        180 
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR 

       190        200        210        220        230        240 
GVEFVCCPLA EESDSVDSAD AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE 

       250        260        270        280        290        300 
EADDDEDVED GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV 

       310        320        330        340        350        360 
DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK ADKKAVIQHF 

       370        380        390        400        410        420 
QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN YITALQAVPP RPHHVFNMLK 

       430        440        450        460        470        480 
KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ IRSQVMTHLR VIYERMNQSL SLLYNVPAVA 

       490        500        510        520        530        540 
EEIQDEVDEL LQKEQNYSDD VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL 

       550        560        570        580        590        600 
DDLQPWHPFG VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF 

       610        620        630        640        650        660 
GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK KQYTSIHHGV 

       670        680        690 
VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK98319.1.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH70409.1.
Tissue: Brain EMBL AAH70409.1.
[8]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[9]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[10]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE27986.1.
[11]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDK98319.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC070409 mRNA. Translation: AAH70409.1.
AK147543 mRNA. Translation: BAE27986.1.
CH466521 Genomic DNA. Translation: EDK98319.1.
RefSeqNP_001185752.1. NM_001198823.1.
NP_001185753.1. NM_001198824.1.
NP_001185754.1. NM_001198825.1.
NP_001185755.1. NM_001198826.1.
NP_031497.2. NM_007471.3.
UniGeneMm.277585.
Mm.489029.
Mm.490986.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11820.
KEGGmmu:11820.
UCSCuc007zto.2. mouse.

Organism-specific databases

CTD351.
MGIMGI:88059. App.

Phylogenomic databases

GeneTreeENSGT00530000063252.
HOVERGENHBG000051.
KOK04520.
OMATHAHIVI.

Gene expression databases

GenevestigatorQ6GR78.

Family and domain databases

Gene3D3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
InterProIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR028866. APP.
IPR019543. APP_amyloid_C.
[Graphical view]
PANTHERPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSPR00203. AMYLOIDA4.
PR00204. BETAAMYLOID.
SMARTSM00006. A4_EXTRA. 1 hit.
[Graphical view]
SUPFAMSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSapp. mouse.
NextBio279717.
SOURCESearch...

Entry information

Entry nameQ6GR78_MOUSE
AccessionPrimary (citable) accession number: Q6GR78
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)